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AB262900

Anti-Activin Receptor Type IIA/ACVR2A antibody

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Rabbit Polyclonal Activin Receptor Type IIA/ACVR2A antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human ACVR2A aa 100-150.

View Alternative Names

ACVR2, ACVR2A, Activin receptor type-2A, Activin receptor type IIA, ACTR-IIA, ACTRIIA

5 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Activin Receptor Type IIA/ACVR2A antibody (AB262900)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Activin Receptor Type IIA/ACVR2A antibody (AB262900)

Paraffin-embedded Human skin tissue stained for Activin Receptor Type IIA/ACVR2A using ab262900 at 1/20 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Activin Receptor Type IIA/ACVR2A antibody (AB262900)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Activin Receptor Type IIA/ACVR2A antibody (AB262900)

Paraffin-embedded Human testis tissue stained for Activin Receptor Type IIA/ACVR2A using ab262900 at 1/20 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Activin Receptor Type IIA/ACVR2A antibody (AB262900)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Activin Receptor Type IIA/ACVR2A antibody (AB262900)

Paraffin-embedded Human cerebral cortex tissue stained for Activin Receptor Type IIA/ACVR2A using ab262900 at 1/20 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Activin Receptor Type IIA/ACVR2A antibody (AB262900)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Activin Receptor Type IIA/ACVR2A antibody (AB262900)

Paraffin-embedded Human gastrointestinal tissue stained for Activin Receptor Type IIA/ACVR2A using ab262900 at 1/20 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Activin Receptor Type IIA/ACVR2A antibody (AB262900)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Activin Receptor Type IIA/ACVR2A antibody (AB262900)

Paraffin-embedded Human endometrium tissue stained for Activin Receptor Type IIA/ACVR2A using ab262900 at 1/20 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ACVR2A aa 100-150. The exact immunogen used to generate this antibody is proprietary information.

P27037

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Activin Receptor Type IIA also known as ACVR2A or ACVR2 is an important component in the activin signaling pathway. This receptor is a serine/threonine kinase that binds to activins and other ligands initiating various cellular responses. The ACVR2A protein has a known mass of about 59 kDa. This receptor is widely expressed in human tissues including the brain testes and ovaries reflecting its diverse functional roles in the body.
Biological function summary

This receptor plays important roles in cellular growth differentiation and apoptosis. ACVR2A partakes in forming signaling complexes by pairing with type I receptors to propagate downstream signals upon ligand binding. This interaction activates SMAD proteins transmitting signals into the nucleus to affect gene expression patterns pivotal for development and homeostasis.

Pathways

ACVR2A significantly influences the TGF-beta signaling pathway. It works alongside other proteins like SMAD2 and SMAD3 orchestrating processes that regulate cellular proliferation and differentiation. This receptor also contributes to the activin pathway impacting tools in embryonic development and immune responses through its interactions with related proteins.

ACVR2A has notable associations with cancer and muscle wasting conditions such as cachexia. Experts study its connection with the myostatin protein where its signaling influences muscle growth and degeneration. Alterations in ACVR2A's function or expression can contribute to cancer progression and the muscle wasting commonly observed in chronic illness patients making it a target of interest for therapeutic interventions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A (PubMed : 17911401, PubMed : 10652306). Mediates induction of adipogenesis by GDF6 (By similarity).
See full target information ACVR2A
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Product promise

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