Rabbit Polyclonal Activin Receptor Type IIA/ACVR2A antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ACVR2A aa 250 to C-terminus.
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- Stem cell research & therapy 11:4722020Human placenta-derived mesenchymal stem cells stimulate ovarian function via miR-145 and bone morphogenetic protein signaling in aged rats.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKyeoung-Hwa Kim et. al.PubMed 33153492
- Frontiers in bioengineering and biotechnology 8:5342020Automated Hypothesis Generation to Identify Signals Relevant in the Development of Mammalian Cell and Tissue Bioprocesses, With Validation in a Retinal Culture System.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDerek Toms et. al.PubMed 32582664
- Neural development 11:42016Region-specific role of growth differentiation factor-5 in the establishment of sympathetic innervation.Applications:ICCReactive species:Unspecified reactive speciesGerard W O'Keeffe et. al.PubMed 26878848
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human ACVR2A aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P27037
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Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Rat | Predicted |
| Cow | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/5000 - 1/20000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Cow, Rat | Dilution info - | Notes - |
Associated Products
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Target data
Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A (PubMed:17911401). Mediates induction of adipogenesis by GDF6 (By similarity).
Alternative names
ACVR2, ACVR2A, Activin receptor type-2A, Activin receptor type IIA, ACTR-IIA, ACTRIIA
Recommended products
Rabbit Polyclonal Activin Receptor Type IIA/ACVR2A antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ACVR2A aa 250 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human ACVR2A aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P27037
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Activin Receptor Type IIA also known as ACVR2A or ACVR2 is an important component in the activin signaling pathway. This receptor is a serine/threonine kinase that binds to activins and other ligands initiating various cellular responses. The ACVR2A protein has a known mass of about 59 kDa. This receptor is widely expressed in human tissues including the brain testes and ovaries reflecting its diverse functional roles in the body.
- Biological function summary
This receptor plays important roles in cellular growth differentiation and apoptosis. ACVR2A partakes in forming signaling complexes by pairing with type I receptors to propagate downstream signals upon ligand binding. This interaction activates SMAD proteins transmitting signals into the nucleus to affect gene expression patterns pivotal for development and homeostasis.
- Pathways
ACVR2A significantly influences the TGF-beta signaling pathway. It works alongside other proteins like SMAD2 and SMAD3 orchestrating processes that regulate cellular proliferation and differentiation. This receptor also contributes to the activin pathway impacting tools in embryonic development and immune responses through its interactions with related proteins.
- Associated diseases and disorders
ACVR2A has notable associations with cancer and muscle wasting conditions such as cachexia. Experts study its connection with the myostatin protein where its signaling influences muscle growth and degeneration. Alterations in ACVR2A's function or expression can contribute to cancer progression and the muscle wasting commonly observed in chronic illness patients making it a target of interest for therapeutic interventions.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-Activin Receptor Type IIA/ACVR2A antibody (ab96793)
7.5% SDS PAGE
All lanes: Western blot - Anti-Activin Receptor Type IIA/ACVR2A antibody (ab96793) at 1/10000 dilution
Lane 1: HeLa whole cell lysate at 30 µg
Lane 2: Hep G2 whole cell lysate at 30 µg
Predicted band size: 58 kDa
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