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AB96793

Anti-Activin Receptor Type IIA/ACVR2A antibody

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(4 Publications)

Rabbit Polyclonal Activin Receptor Type IIA/ACVR2A antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ACVR2A aa 250 to C-terminus.

View Alternative Names

ACVR2, ACVR2A, Activin receptor type-2A, Activin receptor type IIA, ACTR-IIA, ACTRIIA

1 Images
Western blot - Anti-Activin Receptor Type IIA/ACVR2A antibody (AB96793)
  • WB

Unknown

Western blot - Anti-Activin Receptor Type IIA/ACVR2A antibody (AB96793)

7.5% SDS PAGE

All lanes:

Western blot - Anti-Activin Receptor Type IIA/ACVR2A antibody (ab96793) at 1/10000 dilution

Lane 1:

HeLa whole cell lysate at 30 µg

Lane 2:

Hep G2 whole cell lysate at 30 µg

Predicted band size: 58 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human ACVR2A aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P27037

Specificity

Based on sequence homology, this antibody may cross react with Activin Receptor Type IIB protein.

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Alternative Products

Primary Antibodies

AB134082

Anti-Activin Receptor Type IIA/ACVR2A antibody [EPR7407]

RabMAb|Recombinant|20ul selling size

Western blot - Anti-Activin Receptor Type IIA/ACVR2A antibody [EPR7407] (AB134082)

  • 0
  • 0
Primary Antibodies

AB262900

Anti-Activin Receptor Type IIA/ACVR2A antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Activin Receptor Type IIA/ACVR2A antibody (AB262900)

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Primary Antibodies

AB78412

Anti-Activin Receptor Type IIA/ACVR2A antibody [MM0058-6J16]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Activin Receptor Type IIA/ACVR2A antibody [MM0058-6J16] (AB78412)

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AB155999

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SDHC antibody [EPR11035(B)] (AB155999)

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Primary Antibodies

AB195807

Anti-NDUFS6 antibody [EPR15957]

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NDUFS6 antibody [EPR15957] (AB195807)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/5000 - 1/20000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Activin Receptor Type IIA also known as ACVR2A or ACVR2 is an important component in the activin signaling pathway. This receptor is a serine/threonine kinase that binds to activins and other ligands initiating various cellular responses. The ACVR2A protein has a known mass of about 59 kDa. This receptor is widely expressed in human tissues including the brain testes and ovaries reflecting its diverse functional roles in the body.
Biological function summary

This receptor plays important roles in cellular growth differentiation and apoptosis. ACVR2A partakes in forming signaling complexes by pairing with type I receptors to propagate downstream signals upon ligand binding. This interaction activates SMAD proteins transmitting signals into the nucleus to affect gene expression patterns pivotal for development and homeostasis.

Pathways

ACVR2A significantly influences the TGF-beta signaling pathway. It works alongside other proteins like SMAD2 and SMAD3 orchestrating processes that regulate cellular proliferation and differentiation. This receptor also contributes to the activin pathway impacting tools in embryonic development and immune responses through its interactions with related proteins.

ACVR2A has notable associations with cancer and muscle wasting conditions such as cachexia. Experts study its connection with the myostatin protein where its signaling influences muscle growth and degeneration. Alterations in ACVR2A's function or expression can contribute to cancer progression and the muscle wasting commonly observed in chronic illness patients making it a target of interest for therapeutic interventions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A (PubMed : 17911401, PubMed : 10652306). Mediates induction of adipogenesis by GDF6 (By similarity).
See full target information ACVR2A
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Cancer gene therapy 28:514-528 PubMed33223523

2020

microRNA-211-mediated targeting of the INHBA-TGF-β axis suppresses prostate tumor formation and growth.

Applications

Unspecified application

Species

Unspecified reactive species

Zhifeng Zhao,Kai Wang,Shanfeng Tan

Stem cell research & therapy 11:472 PubMed33153492

2020

Human placenta-derived mesenchymal stem cells stimulate ovarian function via miR-145 and bone morphogenetic protein signaling in aged rats.

Applications

Unspecified application

Species

Unspecified reactive species

Kyeoung-Hwa Kim,Eun-Young Kim,Gi Jin Kim,Jung-Jae Ko,Kwang Yul Cha,Mi Kyung Koong,Kyung-Ah Lee

Frontiers in bioengineering and biotechnology 8:534 PubMed32582664

2020

Automated Hypothesis Generation to Identify Signals Relevant in the Development of Mammalian Cell and Tissue Bioprocesses, With Validation in a Retinal Culture System.

Applications

Unspecified application

Species

Unspecified reactive species

Derek Toms,Abdullah Al-Ani,Saud Sunba,Qing Yun Victor Tong,Matthew Workentine,Mark Ungrin

Neural development 11:4 PubMed26878848

2016

Region-specific role of growth differentiation factor-5 in the establishment of sympathetic innervation.

Applications

ICC

Species

Unspecified reactive species

Gerard W O'Keeffe,Humberto Gutierrez,Laura Howard,Christopher W Laurie,Catarina Osorio,Núria Gavaldà,Sean L Wyatt,Alun M Davies
View all publications
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Product promise

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