JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB78412

Anti-Activin Receptor Type IIA/ACVR2A antibody [MM0058-6J16]

Be the first to review this product! Submit a review

|

(1 Publication)

Mouse Monoclonal Activin Receptor Type IIA/ACVR2A antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ACVR2A.

View Alternative Names

ACVR2, ACVR2A, Activin receptor type-2A, Activin receptor type IIA, ACTR-IIA, ACTRIIA

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Activin Receptor Type IIA/ACVR2A antibody [MM0058-6J16] (AB78412)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Activin Receptor Type IIA/ACVR2A antibody [MM0058-6J16] (AB78412)

ab78412 at 1/100 dilution staining Activin Receptor Type IIA/ACVR2A in human placental tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin embedded sections).

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

MM0058-6J16

Isotype

IgG2

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ACVR2A. The exact immunogen used to generate this antibody is proprietary information.

P27037

Specificity

Specific for human Activin RIIA. No cross reactivity was found to hActivin RI and RIIB.

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Activin Receptor Type IIA also known as ACVR2A or ACVR2 is an important component in the activin signaling pathway. This receptor is a serine/threonine kinase that binds to activins and other ligands initiating various cellular responses. The ACVR2A protein has a known mass of about 59 kDa. This receptor is widely expressed in human tissues including the brain testes and ovaries reflecting its diverse functional roles in the body.
Biological function summary

This receptor plays important roles in cellular growth differentiation and apoptosis. ACVR2A partakes in forming signaling complexes by pairing with type I receptors to propagate downstream signals upon ligand binding. This interaction activates SMAD proteins transmitting signals into the nucleus to affect gene expression patterns pivotal for development and homeostasis.

Pathways

ACVR2A significantly influences the TGF-beta signaling pathway. It works alongside other proteins like SMAD2 and SMAD3 orchestrating processes that regulate cellular proliferation and differentiation. This receptor also contributes to the activin pathway impacting tools in embryonic development and immune responses through its interactions with related proteins.

ACVR2A has notable associations with cancer and muscle wasting conditions such as cachexia. Experts study its connection with the myostatin protein where its signaling influences muscle growth and degeneration. Alterations in ACVR2A's function or expression can contribute to cancer progression and the muscle wasting commonly observed in chronic illness patients making it a target of interest for therapeutic interventions.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A (PubMed : 17911401). Mediates induction of adipogenesis by GDF6 (By similarity).
See full target information ACVR2A
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Biology of reproduction 98:683-694 PubMed29409020

2018

Follicular localization of growth differentiation factor 8 and its receptors in normal and polycystic ovary syndrome ovaries.

Applications

Unspecified application

Species

Unspecified reactive species

Ting-Ting Lin,Hsun-Ming Chang,Xiao-Ling Hu,Peter C K Leung,Yi-Min Zhu
View all publications
style
left-column
style
left-column
style
right-column

Alternative Products

Primary Antibodies

AB96793

Anti-Activin Receptor Type IIA/ACVR2A antibody

Western blot - Anti-Activin Receptor Type IIA/ACVR2A antibody (AB96793)

  • 0
  • 0
Primary Antibodies

AB262900

Anti-Activin Receptor Type IIA/ACVR2A antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Activin Receptor Type IIA/ACVR2A antibody (AB262900)

  • 0
  • 0
Primary Antibodies

AB134082

Anti-Activin Receptor Type IIA/ACVR2A antibody [EPR7407]

RabMAb|Recombinant|20ul selling size

Western blot - Anti-Activin Receptor Type IIA/ACVR2A antibody [EPR7407] (AB134082)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB180185

Anti-Activin Receptor Type IIB/ACVR2B antibody [EPR10739]

RabMAb|Recombinant

Western blot - Anti-Activin Receptor Type IIB/ACVR2B antibody [EPR10739] (AB180185)

  • 0
  • 0
Primary Antibodies

AB70203

Anti-MTHFD1 antibody

Western blot - Anti-MTHFD1 antibody (AB70203)

  • 0
  • 0
Primary Antibodies

AB169545

Anti-CD105 antibody [EPR10145-12]

RabMAb|Recombinant|KO Validated

Western blot - Anti-CD105 antibody [EPR10145-12] (AB169545)

  • 4
  • 3
Primary Antibodies

AB155999

Anti-SDHC antibody [EPR11035(B)]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SDHC antibody [EPR11035(B)] (AB155999)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com