Anti-ADAM12 antibody - Aminoterminal end
4
(3 Reviews)
|
(10 Publications)
Rabbit Polyclonal ADAM12 antibody. Suitable for Flow Cyt, WB, ICC/IF, IHC-Fr and reacts with Mouse, Rat, Pig, Human samples. Cited in 10 publications. Immunogen corresponding to Synthetic Peptide within Human ADAM12.
View Alternative Names
MLTN, UNQ346/PRO545, ADAM12, Disintegrin and metalloproteinase domain-containing protein 12, ADAM 12, Meltrin-alpha
- WB
Unknown
Western blot - Anti-ADAM12 antibody - Aminoterminal end (AB39155)
All lanes:
Western blot - Anti-ADAM12 antibody - Aminoterminal end (ab39155) at 1/1000 dilution
All lanes:
Human heart tissue lysate - total protein (<a href='/en-us/products/unavailable/human-heart-tissue-lysate-total-protein-ab29431'>ab29431</a>) at 10 µg
Secondary
All lanes:
Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) (ab65484) at 1/3000 dilution
Predicted band size: 100 kDa
Observed band size: 117 kDa,42 kDa,50 kDa,84 kDa
false
Reactivity data
Properties and storage information
Form
Purification technique
Purification notes
Storage buffer
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The ADAM12 protein holds a role in cell signaling migration and proliferation. It is often part of complexes that interact with other extracellular matrix components influencing cell adhesion and motility. Through its protease activity ADAM12 facilitates growth factor signaling by cleaving membrane-bound precursor proteins to release active growth factors. This activity plays an important role in tissue remodeling and repair.
Pathways
The ADAM12 protein is key in the EGFR signaling pathway where it modulates the availability of epidermal growth factor (EGF) by shedding EGF-like ligands from the cell surface. This action connects ADAM12 with proteins such as ERBB receptors influencing cell division and growth. Another significant pathway is the TGF-beta signaling pathway where ADAM12's interaction with latent TGF-beta complexes can impact the bioavailability of this cytokine therefore relating to proliferation and differentiation of cells.
Product protocols
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Target data
Publications (10)
Recent publications for all applications. Explore the full list and refine your search
Bone research 12:27 PubMed38714649
2024
Applications
Unspecified application
Species
Unspecified reactive species
Frontiers in oncology 11:643039 PubMed34490077
2021
Applications
Unspecified application
Species
Unspecified reactive species
International journal of cancer 146:1281-1292 PubMed31456217
2019
Applications
Unspecified application
Species
Unspecified reactive species
Oncogene 37:6316-6326 PubMed30042416
2018
Applications
Unspecified application
Species
Unspecified reactive species
BioMed research international 2017:9645874 PubMed28357407
2017
Applications
WB
Species
Mouse
F1000Research 5:54 PubMed27335635
2016
Applications
Unspecified application
Species
Unspecified reactive species
Stem cell research & therapy 6:46 PubMed25890097
2015
Applications
ICC, WB
Species
Unspecified reactive species, Unspecified reactive species
Stem cells and development 23:2455-68 PubMed24940624
2014
Applications
Unspecified application
Species
Unspecified reactive species
PloS one 8:e61760 PubMed23671573
2013
Applications
WB, ICC/IF, IHC-Fr, IHC-Fr, ICC/IF, WB
Species
Mouse, Mouse, Mouse, Rat, Rat, Rat
American journal of respiratory cell and molecular 41:449-58 PubMed19213876
2009
Applications
Flow Cyt
Species
Human
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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