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AB217758

Anti-ADAM19 antibody

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(1 Publication)

Rabbit Polyclonal ADAM19 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ADAM19 aa 250-300 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

MLTNB, FKSG34, ADAM19, Disintegrin and metalloproteinase domain-containing protein 19, ADAM 19, Meltrin-beta, Metalloprotease and disintegrin dendritic antigen marker, MADDAM

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADAM19 antibody (AB217758)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADAM19 antibody (AB217758)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human lung carcinoma tissue labeling ADAM19 with ab217758 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human ADAM19 aa 250-300 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q9H013

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ADAM19 also known as meltrin beta is a member of the ADAM (A Disintegrin and Metalloprotease) protein family. With a molecular mass of approximately 100 kDa ADAM19 functions as a protease that is responsible for the shedding of membrane-bound proteins. The protein is expressed in tissues such as the heart skeletal muscle and brain indicating its broad role in various physiological processes. The expression of ADAM19 in these tissues involves regulation of multiple developmental and repair systems.
Biological function summary

ADAM19 is essential in processes like cell adhesion migration and intercellular signaling. This protein is known to interact with other components in the extracellular matrix but specific complex formations with other proteins require further elucidation. It possesses metalloprotease as well as disintegrin domains that contribute to the remodeling of tissues and impact cellular communication. The ability of ADAM19 to process various substrates implies its significant role in physiological functions.

Pathways

ADAM19 participates in Notch and EGFR signaling pathways. These pathways are critical for regulating cell differentiation and proliferation. Notably ADAM19 works alongside proteins like Notch receptors and EGFR in these pathways highlighting its involvement in the controlled release of signaling peptides which modulates downstream effects on cells. Such interactions define its importance in maintaining homeostasis and enabling adaptive responses within tissues.

The malfunction of ADAM19 has been implicated in conditions like cardiac hypertrophy and Alzheimer's disease. In these diseases improper regulation or mutation of ADAM19 may contribute to pathological states. The protein's connection to diseases involves interaction with Notch signaling components and amyloid precursor protein (APP) which are representatives in cardiac and neurodegenerative disease pathways respectively. Research efforts focus on understanding how ADAM19 contributes to disease progression with the hopes of identifying therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity).
See full target information ADAM19
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Regenerative therapy 20:165-186 PubMed35620640

2022

Critical roles of FGF, RA, and WNT signalling in the development of the human otic placode and subsequent lineages in a dish.

Applications

Unspecified application

Species

Unspecified reactive species

Tsubasa Saeki,Sho Yoshimatsu,Mitsuru Ishikawa,Chung-Chau Hon,Ikuko Koya,Shinsuke Shibata,Makoto Hosoya,Chika Saegusa,Kaoru Ogawa,Jay W Shin,Masato Fujioka,Hideyuki Okano
View all publications
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Product promise

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