Rabbit Polyclonal ADAM23 antibody. Suitable for ICC/IF and reacts with Rat samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human ADAM23.
View Alternative Names
MDC3, ADAM23, Disintegrin and metalloproteinase domain-containing protein 23, ADAM 23, MDC-3
- ICC/IF
Unknown
Immunocytochemistry/ Immunofluorescence - Anti-ADAM23 antibody (AB28304)
ICC/IF image of ab28304 stained PC12 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab28304, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.
Reactivity data
Properties and storage information
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Purification technique
Storage buffer
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
ADAM23 plays a role in processes such as cell-cell adhesion and signal transduction. It aids in the regulation of synapse formation and maintenance in neuronal cells which is important for proper neural development and function. ADAM23 is not generally considered a part of large protein complexes but collaborates in the cellular environment impacting spatial cellular frameworks and growth signaling cascades.
Pathways
Multiple mechanisms rely on ADAM23 especially those involved in cell signaling. The protein interacts with integrin pathways influencing cellular adhesion and migration dynamics. Furthermore it works closely with other members of the ADAM family such as ADAM22 in modulating signaling pathways critical for neuronal function and transmission.
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Target data
Publications (3)
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PloS one 17:e0272277 PubMed35984846
2022
Applications
Unspecified application
Species
Unspecified reactive species
Frontiers in immunology 12:785247 PubMed35095860
2022
Applications
Unspecified application
Species
Unspecified reactive species
Neurology(R) neuroimmunology & neuroinflammation 4:e404 PubMed29075658
2017
Applications
Unspecified application
Species
Unspecified reactive species
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