Rabbit Polyclonal ADAM23 antibody. Suitable for ICC/IF and reacts with Rat samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human ADAM23.
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Publications
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- PloS one 17:e02722772022Dysregulation of the hippocampal neuronal network by LGI1 auto-antibodies.Applications:Unspecified applicationReactive species:Unspecified reactive speciesElodie Fels,Marie-Eve Mayeur,Estelle Wayere,Clémentine Vincent,Céline Malleval,Jérôme Honnorat,Olivier PascualPubMed 35984846
- Frontiers in immunology 12:7852472022Anti-Neuronal IgG4 Autoimmune Diseases and IgG4-Related Diseases May Not Be Part of the Same Spectrum: A Comparative Study.Applications:Unspecified applicationReactive species:Unspecified reactive speciesVerena Endmayr,Cansu Tunc,Lara Ergin,Anna De Rosa,Rosa Weng,Lukas Wagner,Thin-Yau Yu,Andreas Fichtenbaum,Thomas Perkmann,Helmuth Haslacher,Nicolas Kozakowski,Carmen Schwaiger,Gerda Ricken,Simon Hametner,Sigrid Klotz,Lívia Almeida Dutra,Christian Lechner,Désirée de Simoni,Kai-Nicolas Poppert,Georg Johannes Müller,Susanne Pirker,Walter Pirker,Aleksandra Angelovski,Matus Valach,Michelangelo Maestri,Melania Guida,Roberta Ricciardi,Florian Frommlet,Daniela Sieghart,Miklos Pinter,Karl Kircher,Gottfried Artacker,Romana Höftberger,Inga KonecznyPubMed 35095860
- Neurology(R) neuroimmunology & neuroinflammation 4:e4042017Improving the antibody-based evaluation of autoimmune encephalitis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLindsey McCracken et. al.PubMed 29075658
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human ADAM23. The exact immunogen used to generate this antibody is proprietary information. Database link O75077
Reactivity data
Select an application| ICC/IF | |
|---|---|
| Rat | Tested |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info 1 µg/mL | Notes - |
Associated Products
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2 products for Alternative Product
Target data
Function
May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.
Alternative names
MDC3, ADAM23, Disintegrin and metalloproteinase domain-containing protein 23, ADAM 23, MDC-3
Recommended products
Rabbit Polyclonal ADAM23 antibody. Suitable for ICC/IF and reacts with Rat samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human ADAM23.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human ADAM23. The exact immunogen used to generate this antibody is proprietary information. Database link O75077
- Purification technique
- Affinity purification Immunogen
- Specificity
ab28304 recognises the Propeptide domain of ADAM23.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ADAM23 also known as A Disintegrin And Metalloprotease 23 is a member of the ADAM family of proteases. This protein has a mass of approximately 95 kDa. ADAM23 is expressed in several tissues but it has a significant presence in the brain. The protein mechanically functions by engaging in protease activities though it is uniquely categorized due to its role beyond traditional proteolytic functions. It interacts with surrounding cell-matrix elements through disintegrin domains.
- Biological function summary
ADAM23 plays a role in processes such as cell-cell adhesion and signal transduction. It aids in the regulation of synapse formation and maintenance in neuronal cells which is important for proper neural development and function. ADAM23 is not generally considered a part of large protein complexes but collaborates in the cellular environment impacting spatial cellular frameworks and growth signaling cascades.
- Pathways
Multiple mechanisms rely on ADAM23 especially those involved in cell signaling. The protein interacts with integrin pathways influencing cellular adhesion and migration dynamics. Furthermore it works closely with other members of the ADAM family such as ADAM22 in modulating signaling pathways critical for neuronal function and transmission.
- Associated diseases and disorders
ADAM23 has shown connections to neurological conditions notably epilepsy and some types of cancer. Disruptions or mutations in the ADAM23 gene have associated alterations in nervous system activity contributing to epilepsy pathogenesis. During cancer progression ADAM23 may interact with tumor-suppressing pathways in which its family member ADAM22 also participates. Understanding ADAM23's role in these diseases can lead to new insights into therapeutic targets.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunocytochemistry/ Immunofluorescence - Anti-ADAM23 antibody (ab28304)
ICC/IF image of ab28304 stained PC12 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab28304, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.
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