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AB173290

Anti-ADAMTS10 antibody [EPR11860]

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(1 Publication)

Rabbit Recombinant Monoclonal ADAMTS10 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

A disintegrin and metalloproteinase with thrombospondin motifs 10, ADAM-TS 10, ADAM-TS10, ADAMTS-10, ADAMTS10

1 Images
Western blot - Anti-ADAMTS10 antibody [EPR11860] (AB173290)
  • WB

Supplier Data

Western blot - Anti-ADAMTS10 antibody [EPR11860] (AB173290)

All lanes:

Western blot - Anti-ADAMTS10 antibody [EPR11860] (ab173290) at 1/1000 dilution

Lane 1:

Fetal heart lysate at 10 µg

Lane 2:

A549 cell lysate at 10 µg

Predicted band size: 121 kDa

false

  • Carrier free

    Anti-ADAMTS10 antibody [EPR11860] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR11860

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Mouse": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ADAMTS10 also referred to as A Disintegrin and Metalloproteinase with Thrombospondin Motifs 10 is a member of the ADAMTS family. This protein has an approximate molecular mass of 110 kDa. The ADAMTS10 protein functions mainly as a metalloprotease involved in the cleavage of extracellular matrix components affecting tissue remodeling and development processes. It is expressed in various tissues including the eyes and heart suggesting its broad role in different physiological contexts.
Biological function summary

ADAMTS10 plays a significant role in maintaining the structure of fibrillin-rich microfibrils which are essential components of the extracellular matrix. It is part of a larger complex involved in cell signaling and tissue integrity. The interaction with fibrillin suggests its involvement in connective tissue maintenance and elastogenesis which is important for normal cellular functions in eye and cardiac tissue.

Pathways

ADAMTS10 provides functionality within fibrillin and microfibril assembly pathways impacting processes like tissue morphogenesis. It associates closely with other matrix proteins like fibrillin-1 and ADAMTSL proteins in these pathways influencing the structural integrity and biomechanical properties of tissues. Additionally its regulation can affect Notch signaling pathways linking to cellular growth and differentiation processes.

ADAMTS10 mutations are linked to Weill-Marchesani syndrome a connective tissue disorder characterized by eye heart and skeletal abnormalities. The protein's activity also associates with glaucoma a condition involving elevated intraocular pressure leading to optic nerve damage. Researchers have noted a connection with LTBP2 (latent-transforming growth factor beta-binding protein 2) in these conditions suggesting that mutations or dysfunctions in this pathway can disrupt fibrillin functions and lead to disease pathogenesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues.
See full target information ADAMTS10
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

PLoS pathogens 20:e1012535 PubMed39255317

2024

Methylation of KSHV vCyclin by PRMT5 contributes to cell cycle progression and cell proliferation.

Applications

Unspecified application

Species

Unspecified reactive species

Danping Niu,Yuanming Ma,Pengyu Ren,Sijia Chang,Chenhui Li,Yong Jiang,Chunyan Han,Ke Lan
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com