Rabbit Polyclonal ADAMTS12 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human ADAMTS12 aa 300-400 conjugated to Keyhole Limpet Haemocyanin.
View Alternative Names
UNQ1918/PRO4389, ADAMTS12, A disintegrin and metalloproteinase with thrombospondin motifs 12, ADAM-TS 12, ADAM-TS12, ADAMTS-12
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADAMTS12 antibody (AB203102)
Immunohistochemical analysis of formalin-fixed, paraffin embedded Human lung carcinoma tissue labeling ADAMTS12 with ab203102 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADAMTS12 antibody (AB203102)
Immunohistochemical analysis of formalin-fixed, paraffin embedded Human colon carcinoma tissue labeling ADAMTS12 with ab203102 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.
Reactivity data
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Biological function summary
The interactions with other matrix components allow ADAMTS12 to mediate matrix organization and degradation. It does not form part of a larger protein complex on its own but interacts with extracellular matrix proteins like aggrecan and versican. These interactions facilitate the breakdown of large proteoglycans aiding tissue morphogenesis and repair.
Pathways
ADAMTS12 participates in the extracellular matrix organization and degradation pathways. These pathways involve proteins such as aggrecanase and versicanase which ADAMTS12 closely relates to through its proteolytic activity. It plays a significant role in matrix remodelling which is essential for cellular migration and differentiation processes.
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Publications (4)
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African health sciences 22:56-63 PubMed37092087
2023
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Frontiers in oncology 12:849717 PubMed35280819
2022
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Unspecified reactive species
Cancer cell international 22:21 PubMed35033072
2022
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Unspecified reactive species
Journal of molecular endocrinology 64:155-164 PubMed31958317
2020
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Unspecified application
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Unspecified reactive species
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