AB71550

Anti-ADAMTS13 antibody

Name: Anti-ADAMTS13 antibody (ab71550) | Abcam
Brand: Abcam Limited
SKU: AB71550
Rating: 4 (1 reviews)

(1 Review)

(4 Publications)

Rabbit Polyclonal ADAMTS13 antibody. Suitable for WB, IHC-P and reacts with Mouse samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human ADAMTS13.

View Alternative Names

C9orf8, UNQ6102/PRO20085, ADAMTS13, A disintegrin and metalloproteinase with thrombospondin motifs 13, ADAM-TS 13, ADAM-TS13, ADAMTS-13, von Willebrand factor-cleaving protease, vWF-CP, vWF-cleaving protease

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human ADAMTS13. The exact immunogen used to generate this antibody is proprietary information.

Q76LX8

Specificity

This antibody reacts specifically with human 154 kDa ADAMTS13 protein

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Reactivity data

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Properties and storage information

Form

Liquid

Purity

Whole antiserum

Storage buffer

Constituents: Whole serum

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ADAMTS13 also known as von Willebrand factor-cleaving protease (VWFCP) is a zinc-containing metalloprotease with a molecular mass of approximately 190 kDa. This protein belongs to the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family and exhibits a complex structure with specific domains including a metalloprotease and a disintegrin-like domain. ADAMTS13 is produced mainly in the liver and circulates in the blood plasma. Research shows that it primarily facilitates the cleavage of von Willebrand factor (vWF) a large multimeric protein essential for blood clotting.

Biological function summary

ADAMTS13 plays a role in regulating the size and function of von Willebrand factor (vWF) ensuring proper hemostatic balance. The enzyme prevents the accumulation of ultra-large vWF multimers which can lead to spontaneous platelet aggregation and thrombus formation. Although ADAMTS13 acts independently its function is closely linked to the dynamics of vWF in response to vascular injury. Properly functioning ADAMTS13 aids in maintaining normal blood flow by preventing unnecessary clot formation in the bloodstream.

Pathways

ADAMTS13 is critical in the coagulation and hemostatic pathways. It operates by modulating the activity of vWF which plays an essential role in platelet adhesion and aggregation forming part of the coagulation cascade. A significant relationship exists between ADAMTS13 and vWF in these pathways as the protease controls vWF multimer size directly impacting clot formation. In the context of hemostatic balance ADAMTS13 intersects with factors like thrombin and fibrinogen which further contribute to clotting processes.

ADAMTS13 deficiency or dysfunction is associated with thrombotic thrombocytopenic purpura (TTP) a rare but severe blood disorder. In TTP the reduced activity of ADAMTS13 leads to an over-accumulation of ultra-large vWF multimers resulting in excessive platelet aggregation and microvascular thrombosis. Another related condition is atypical hemolytic uremic syndrome (aHUS) where abnormal ADAMTS13 activity might exacerbate the disease pathology. Both disorders highlight the critical need for balanced ADAMTS13 function in maintaining vascular health and highlight its potential as a therapeutic target.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

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Target data

Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation.

See full target information ADAMTS13

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Cells 14: PubMed39851513

2025

ADAMTS13 Improves Endothelial Function and Reduces Inflammation in Diabetic Retinopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Ahmed M Abu El-Asrar,Mohd I Nawaz,Ajmal Ahmad,Mairaj Siddiquei,Eef Allegaert,Lowie Adyns,Lotte Vanbrabant,Priscilla W Gikandi,Gert De Hertogh,Sofie Struyf,Ghislain Opdenakker

Molecules (Basel, Switzerland) 27: PubMed36144730

2022

Differential Expression and Localization of ADAMTS Proteinases in Proliferative Diabetic Retinopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Ahmed M Abu El-Asrar,Mohd Imtiaz Nawaz,Eef Allegaert,Mohammad Mairaj Siddiquei,Ajmal Ahmad,Priscilla Gikandi,Gert De Hertogh,Ghislain Opdenakker

The Journal of thoracic and cardiovascular surgery 147:1634-43 PubMed24139617

2013

Insights into the mechanism(s) of von Willebrand factor degradation during mechanical circulatory support.

Applications

Species

Unspecified reactive species

Carlo R Bartoli,Sujith Dassanayaka,Kenneth R Brittian,Andrew Luckett,Srinivas Sithu,Thorsten Siess,Daniel H Raess,Paul A Spence,Steven C Koenig,Robert D Dowling,Stanley E D'Souza

Blood 115:1640-9 PubMed20032502

2009

An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF.

Applications

Species

Human

Wouter Pos,James T B Crawley,Rob Fijnheer,Jan Voorberg,David A Lane,Brenda M Luken

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ADAMTS13 antibody

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

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Reactivity data

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

Product promise