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AB45047

Anti-ADAMTS15 antibody

1

(1 Review)

|

(4 Publications)

Rabbit Polyclonal ADAMTS15 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human ADAMTS15.

View Alternative Names

A disintegrin and metalloproteinase with thrombospondin motifs 15, ADAM-TS 15, ADAM-TS15, ADAMTS-15, ADAMTS15

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human ADAMTS15. The exact immunogen used to generate this antibody is proprietary information.

Q8TE58

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 2.9% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ADAMTS15 also known as A Disintegrin And Metalloproteinase with Thrombospondin motifs 15 is a member of the ADAMTS family of zinc-dependent metalloproteases. It is involved in the degradation of extracellular matrix components especially proteoglycans. This protease has a mass of approximately 110 kDa. Researchers found ADAMTS15 expression mainly in cartilage and testis highlighting its tissue-specific roles. Understanding its mechanical role as a proteoglycanase gives insight into its contribution to tissue remodeling dynamics.
Biological function summary

ADAMTS15 plays a significant role in extracellular matrix organization and turnover. It mediates proteolytic processing of aggrecan and other proteoglycans which are important for structural integrity in tissues like cartilage. It operates independently rather than as part of a complex. The proteolytic function of ADAMTS15 is essential in processes like embryonic development cell migration and angiogenesis emphasizing its influence in maintaining normal physiological functions.

Pathways

ADAMTS15 is implicated in the proteoglycan turnover pathway and the Wnt signaling pathway. Its activities within these pathways contribute to cellular matrix degradation and regulation of cell growth and differentiation. ADAMTS15 associates with other proteins such as aggrecan and collagen that participate in matrix degradation. It shows functional similarities and interactions with other ADAMTS family members like ADAMTS4 and ADAMTS5 which further support its role in matrix dynamics.

Researchers link ADAMTS15 with osteoarthritis and some forms of cancer. In osteoarthritis abnormal activity of ADAMTS15 leads to excessive degradation of cartilage matrix contributing to joint degeneration. Proteins like aggrecan targeted by ADAMTS15 play a role in this disorder. In cancer ADAMTS15 involvement appears in the regulation of tumor microenvironment dynamics and metastasis. Its interaction with structural components of the matrix makes it a potential therapeutic target in both contexts.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Metalloprotease which has proteolytic activity against the proteoglycan VCAN, cleaving it at the 'Glu-1428-|-1429-Ala' site. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration.
See full target information ADAMTS15
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Biomolecules 10: PubMed32156081

2020

Treatment of Dystrophic Mice with an ADAMTS-5 Specific Monoclonal Antibody Increases the Ex Vivo Strength of Isolated Fast Twitch Hindlimb Muscles.

Applications

Unspecified application

Species

Unspecified reactive species

Alex B Addinsall,Leonard G Forgan,Natasha L McRae,Rhys W Kelly,Penny L McDonald,Bryony McNeill,Daniel R McCulloch,Nicole Stupka

International journal of molecular sciences 18: PubMed29211034

2017

Glucocorticoids Improve Myogenic Differentiation In Vitro by Suppressing the Synthesis of Versican, a Transitional Matrix Protein Overexpressed in Dystrophic Skeletal Muscles.

Applications

Unspecified application

Species

Unspecified reactive species

Natasha McRae,Leonard Forgan,Bryony McNeill,Alex Addinsall,Daniel McCulloch,Chris Van der Poel,Nicole Stupka

The Journal of biological chemistry 288:37267-76 PubMed24220035

2013

Biosynthesis and expression of a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats-15: a novel versican-cleaving proteoglycanase.

Applications

WB

Species

Human

Carolyn M Dancevic,Fiona W Fraser,Adam D Smith,Nicole Stupka,Alister C Ward,Daniel R McCulloch

Cancer investigation 28:698-710 PubMed20590445

2010

Androgen regulates ADAMTS15 gene expression in prostate cancer cells.

Applications

WB

Species

Human

Chidi N Molokwu,Olajumoke O Adeniji,Shankar Chandrasekharan,Freddie C Hamdy,David J Buttle
View all publications
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