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AB45048

Anti-ADAMTS16 antibody

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(6 Publications)

Rabbit Polyclonal ADAMTS16 antibody. Suitable for WB and reacts with Mouse samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human ADAMTS16.

View Alternative Names

KIAA2029, ADAMTS16, A disintegrin and metalloproteinase with thrombospondin motifs 16, ADAM-TS 16, ADAM-TS16, ADAMTS-16

1 Images
Western blot - Anti-ADAMTS16 antibody (AB45048)
  • WB

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Western blot - Anti-ADAMTS16 antibody (AB45048)

Several different splice variants of ADAMTS-16 have been reported : 151.38 kDa, 136.2 kDa and 119.5 kDa.Two shorter versions of 62kDa and 56kDa are also reported, lacking the MP domain.

All lanes:

Western blot - Anti-ADAMTS16 antibody (ab45048) at 1/1000 dilution

Lane 1:

Whole cell lysate prepared from mouse lung mesenchymal MLg cells (treated with SF)

Lane 2:

Whole cell lysate prepared from mouse lung mesenchymal MLg cells (treated with TPA)

Lane 3:

Whole cell lysate prepared from mouse lung mesenchymal MLg cells (treated with IL1-alpha)

Lane 4:

Whole cell lysate prepared from mouse lung mesenchymal MLg cells (treated with RA)

Predicted band size: 136 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Synthetic Peptide within Human ADAMTS16. The exact immunogen used to generate this antibody is proprietary information.

Q8TE57

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>" } } }
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Product details

We have a range of domain specific antibodies for this target. For a full list please see all ADAMTS16 antibodies.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 2.9% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ADAMTS16 also known as A Disintegrin And Metalloproteinase with Thrombospondin motifs 16 is a protease enzyme that plays a role in extracellular matrix regulation. It belongs to the family of ADAMTS proteins and has a molecular mass of approximately 170 kDa. This protein is expressed in various tissues including the kidney brain and testis. Its mechanical role involves processing extracellular matrix components such as proteoglycans.
Biological function summary

ADAMTS16 affects the remodeling of the extracellular matrix through its enzymatic activity. It participates in modulating cell signaling and tissue architecture essential for maintaining cellular homeostasis. Although it is not typically part of a large complex ADAMTS16 interacts with matrix substrates indicating its involvement in matrix composition and regulation of matrix-dependent cellular processes.

Pathways

Physiological functions of ADAMTS16 align with the matrix metalloproteinase pathway and the Wnt signaling pathway. Within these pathways ADAMTS16 influences tissue remodeling and developmental processes. It shares a relationship with other proteins such as ADAMTS1 and ADAMTS4 highlighting its role in coordinating extracellular matrix interactions.

ADAMTS16 has associations with hypertension and certain reproductive disorders. Alterations in its function can impact blood pressure regulation due to its effects on the vascular extracellular matrix. It also relates to reproductive conditions with a connection to ADAMTS9 which can impact fertilization processes and other reproductive events.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information ADAMTS16
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Cureus 17:e89796 PubMed40937200

2025

miR-145-Mediated Tumor Suppression in Bladder Urothelial Carcinoma via Targeting the ADAMTS5/Wnt Signaling Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Jiang Wei,Zhang L Feng,Cheny Y Mao,Huang Xi,Fu Ming,Chen Jun

Pathology international 73:297-305 PubMed37132990

2023

ADAM metallopeptidase with thrombospondin type 1 motif 16 is a potential marker for prognosis in clear cell renal cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Chen Bai,Deng-Gang Chen

Cardiovascular research 116:956-969 PubMed31297506

2019

ADAMTS16 activates latent TGF-β, accentuating fibrosis and dysfunction of the pressure-overloaded heart.

Applications

Unspecified application

Species

Unspecified reactive species

Yufeng Yao,Changqing Hu,Qixue Song,Yong Li,Xingwen Da,Yubin Yu,Hui Li,Ian M Clark,Qiuyun Chen,Qing K Wang

Human molecular genetics 28:84-95 PubMed30239759

2018

Epigenetic changes in preterm birth placenta suggest a role for ADAMTS genes in spontaneous preterm birth.

Applications

Unspecified application

Species

Unspecified reactive species

Sneha Mani,Jayashri Ghosh,Yemin Lan,Suneeta Senapati,Teri Ord,Carmen Sapienza,Christos Coutifaris,Monica Mainigi

Investigative ophthalmology & visual science 59:1167-1177 PubMed29625437

2018

Metalloproteinase Adamts16 Is Required for Proper Closure of the Optic Fissure.

Applications

Unspecified application

Species

Unspecified reactive species

Mingzhe Cao,Jiamin Ouyang,Jingyi Guo,Siyuan Lin,Shuyi Chen

The Journal of biological chemistry 288:18811-24 PubMed23661704

2013

Transcriptional regulation by the Wilms tumor protein, Wt1, suggests a role of the metalloproteinase Adamts16 in murine genitourinary development.

Applications

Unspecified application

Species

Unspecified reactive species

Charlotte L J Jacobi,Lucas J Rudigier,Holger Scholz,Karin M Kirschner
View all publications
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Product promise

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