Rabbit Polyclonal ADAMTS17 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Immunogen corresponding to Synthetic Peptide within Human A disintegrin and metalloproteinase with thrombospondin motifs 17.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human A disintegrin and metalloproteinase with thrombospondin motifs 17. The exact immunogen used to generate this antibody is proprietary information. Database link Q8TE56
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Expected | Tested |
| Mouse | Tested | Expected |
| Rat | Predicted | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/500.00000 - 1/2000.00000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50.00000 - 1/200.00000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
Target data
Alternative names
A disintegrin and metalloproteinase with thrombospondin motifs 17, ADAM-TS 17, ADAM-TS17, ADAMTS-17, ADAMTS17
Recommended products
Rabbit Polyclonal ADAMTS17 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Immunogen corresponding to Synthetic Peptide within Human A disintegrin and metalloproteinase with thrombospondin motifs 17.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human A disintegrin and metalloproteinase with thrombospondin motifs 17. The exact immunogen used to generate this antibody is proprietary information. Database link Q8TE56
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ADAMTS17 also known as A Disintegrin and Metalloproteinase with Thrombospondin motifs 17 is a zinc-dependent protease with a molecular mass of approximately 128 kDa. This protein is part of the ADAMTS family which are secreted enzymes known for their roles in processing extracellular matrix components. ADAMTS17 appears in several tissues including the eyes reproductive organs and connective tissues. It mainly functions by cleaving specific substrates in the extracellular matrix affecting various physiological processes.
- Biological function summary
ADAMTS17 influences extracellular matrix organization and tissue remodeling. It works by processing proteins like proteoglycans that are key components of the matrix. In particular it is part of a complex that regulates structural integrity and cellular communication within tissues. Disruptions in its function can affect normal extracellular matrix remodeling and influence development and repair processes. Its activity is essential for maintaining proper function and structure in certain tissues making it a significant point of investigation.
- Pathways
The proteins related to ADAMTS17 are primarily involved in the regulation of the extracellular matrix and connective tissue development pathways. One key pathway includes extracellular matrix assembly and degradation where it interacts with substrates like collagen and aggrecan. It relates to proteins such as ADAMTS10 and ADAMTS20 which are part of the same protein family and share similar functions within these pathways. These interactions are important for the normal development and homeostasis of connective tissues.
- Associated diseases and disorders
Dysfunctions in ADAMTS17 have been linked to connective tissue disorders and certain eye diseases. Mutations or altered expression levels of ADAMTS17 can lead to conditions such as Weill-Marchesani syndrome. This protein has relations to fibrillin-1 through its impact on the extracellular matrix contributing to the pathogenesis of such connective tissue diseases. Understanding the role of ADAMTS17 in these conditions is important for developing therapeutic strategies aimed at mitigating the impacts of these disorders.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-ADAMTS17 antibody (ab198881)
Gel: 8% SDS-PAGE
All lanes: Western blot - Anti-ADAMTS17 antibody (ab198881) at 1/1300 dilution
All lanes: NIH 3T3 cell lysate at 40 µg
Developed using the ECL technique.
Predicted band size: 121 kDa
Exposure time: 1hr
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADAMTS17 antibody (ab198881)
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling ADAMTS17 with ab198881 at 1/60 dilution.
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