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AB190073

Anti-ADAMTS19 antibody

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(2 Publications)

Rabbit Polyclonal ADAMTS19 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human A disintegrin and metalloproteinase with thrombospondin motifs 19 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

A disintegrin and metalloproteinase with thrombospondin motifs 19, ADAM-TS 19, ADAM-TS19, ADAMTS-19, ADAMTS19

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADAMTS19 antibody (AB190073)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADAMTS19 antibody (AB190073)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human placenta tissue labeling ADAMTS19 with ab190073 at 10 μg/ml.

Western blot - Anti-ADAMTS19 antibody (AB190073)
  • WB

Supplier Data

Western blot - Anti-ADAMTS19 antibody (AB190073)

All lanes:

Western blot - Anti-ADAMTS19 antibody (ab190073) at 1/1000 dilution

All lanes:

Mouse kidney tissue lysate at 35 µg

Predicted band size: 134 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human A disintegrin and metalloproteinase with thrombospondin motifs 19 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q8TE59

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ADAMTS19 also known as A Disintegrin and Metalloproteinase with Thrombospondin Motifs 19 is a protein that functions as a peptidase specifically involved in the breakdown of extracellular matrix components. It has a molecular weight of approximately 98 kDa. It expresses most prominently in the heart and cartilage tissues where it plays a significant role in maintaining cellular structure and matrix integrity. The protein belongs to the ADAMTS family distinguished by their role in extracellular matrix organization.
Biological function summary

ADAMTS19 plays a function in the developmental processes particularly in skeletal and cardiovascular systems. It is associated with complex assemblies within the extracellular space aiding in the proteolytic processing of matrix proteins. These interactions help regulate cell adhesion migration and tissue remodeling. ADAMTS19 also influences the maturation of key structural proteins within the matrix thereby maintaining normal physiological function.

Pathways

ADAMTS19 engages in the transforming growth factor-beta (TGF-β) signaling and extracellular matrix remodeling pathways. It operates alongside proteins like matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) to balance matrix biosynthesis and degradation. These pathways contribute to cell communication and structural stability impacting tissue development and repair processes.

Mutations or dysregulation of ADAMTS19 has associations with conditions such as cardiac valvular disease and spondylodysplastic Ehlers-Danlos syndrome. In these disorders the protein interacts with other matrix-modifying enzymes like MMPs contributing to abnormal matrix degradation and tissue weakness. These associations suggest that ADAMTS19 has an important role in the pathophysiology of connective tissue disorders and abnormalities in cardiovascular function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information A disintegrin and metalloproteinase with thrombospondin motifs 19
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Biomolecules 11: PubMed33921267

2021

ADAMTS19 Suppresses Cell Migration and Invasion by Targeting S100A16 via the NF-κB Pathway in Human Gastric Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yingming Jiang,Xihu Yu,Yandong Zhao,Jintuan Huang,Tuoyang Li,Hao Chen,Junyi Zhou,Zhenze Huang,Zuli Yang

Cancer letters 477:19-30 PubMed32120023

2020

IGFBP2 regulates PD-L1 expression by activating the EGFR-STAT3 signaling pathway in malignant melanoma.

Applications

Unspecified application

Species

Unspecified reactive species

Ting Li,Chao Zhang,Gang Zhao,Xinwei Zhang,Mengze Hao,Shafat Hassan,Min Zhang,Hong Zheng,Da Yang,Liang Liu,Farideh Mehraein-Ghomi,Xu Bai,Kexin Chen,Wei Zhang,Jilong Yang
View all publications
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Product promise

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