AB84792

Anti-ADAMTS4 antibody

Name: Anti-ADAMTS4 antibody (ab84792) | Abcam
Brand: Abcam Limited
SKU: AB84792

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(16 Publications)

Rabbit Polyclonal ADAMTS4 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 16 publications. Immunogen corresponding to Synthetic Peptide within Human ADAMTS4.

View Alternative Names

KIAA0688, UNQ769/PRO1563, ADAMTS4, A disintegrin and metalloproteinase with thrombospondin motifs 4, ADAM-TS 4, ADAM-TS4, ADAMTS-4, ADMP-1, Aggrecanase-1

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADAMTS4 antibody (AB84792)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADAMTS4 antibody (AB84792)

ab84792 at a 1/200 dilution staining ADAMTS4 in Human brain tissue.

Unknown

Western blot - Anti-ADAMTS4 antibody (AB84792)

All lanes:

Western blot - Anti-ADAMTS4 antibody (ab84792) at 1/1000 dilution

All lanes:

Human fetal brain lysates

Predicted band size: 90 kDa

Observed band size: 90 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human ADAMTS4. The exact immunogen used to generate this antibody is proprietary information.

O75173

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/500", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Lyophilized

Reconstitution

reconstitute with water at 200µL

Purification technique

Affinity purification Protein A/G

Storage buffer

Preservative: 0.02% Sodium azide

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ADAMTS4 also known as aggrecanase-1 is a protein responsible for extracellular matrix degradation. It weighs approximately 90 kDa. This metalloproteinase is expressed in various tissues including cartilage and synovial tissue. It cleaves aggrecan a core protein of the proteoglycan into fragments impacting the integrity and function of the cartilage matrix. It is secreted as a latent enzyme and undergoes activation in the extracellular space.

Biological function summary

ADAMTS4 influences tissue remodeling through the breakdown of cartilage. It contributes to the disassembly of aggrecan and other matrix components influencing extracellular matrix turnover. As part of a group of similar enzymes it plays a role in proteolytic processes important for normal tissue maintenance and repair. Its actions affect the balance between matrix synthesis and degradation which is important for maintaining tissue homeostasis.

Pathways

ADAMTS4 participates in pathways such as the inflammation-related cytokine signaling and the degradation of the extracellular matrix. This protein interacts closely with ADAMTS5 contributing to matrix degradation and modulation of inflammatory processes. In these pathways the balanced activity of ADAMTS4 is essential for proper cartilage function and the resolution of inflammation in tissues.

ADAMTS4 is notably linked to osteoarthritis and rheumatoid arthritis. These conditions involve excessive cartilage breakdown where ADAMTS4 and ADAMTS5 contribute significantly to disease progression through aggrecan degradation. Understanding the activity and regulation of ADAMTS4 offers insights into potential therapeutic strategies for managing cartilage degeneration and inflammatory joint diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.

See full target information ADAMTS4

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Publications (16)

Recent publications for all applications. Explore the full list and refine your search

Histology and histopathology :18959 PubMed40662219

2025

ADAMTS4 is expressed in different cells and tissues in leprosy skin lesions: A potential biomarker and therapeutic target for leprosy and its reactional phenomena.

Applications

Unspecified application

Species

Unspecified reactive species

Cleverson Soares,Igor Garrido,Rafael Soares,Natália Virgili,Luciana Fachin,Patricia Rosa,Ana Paula Trombone,Andrea Belone

Journal of orthopaedic surgery and research 18:189 PubMed36899420

2023

Anemonin reduces hydrogen peroxide-induced oxidative stress, inflammation and extracellular matrix degradation in nucleus pulposus cells by regulating NOX4/NF-κB signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Zhijia Ma,Pengfei Yu,Xiaochun Li,Feng Dai,Hong Jiang,Jintao Liu

Journal of orthopaedic surgery and research 18:186 PubMed36894989

2023

MiR-760 targets HBEGF to control cartilage extracellular matrix degradation in osteoarthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Yingchun Zhu,Chi Zhang,Bo Jiang,Qirong Dong

Oxidative medicine and cellular longevity 2022:7655142 PubMed35265264

2022

Naringin protects human nucleus pulposus cells against TNF--induced inflammation, oxidative stress, and loss of cellular homeostasis by enhancing autophagic flux via AMPK/SIRT1 activation.

Applications

Unspecified application

Species

Unspecified reactive species

Renchang Chen,Shang Gao,Huapeng Guan,Xin Zhang,Yuliang Gao,Youxiang Su,Yun Song,Yuehua Jiang,Nianhu Li

Biomedicines 9: PubMed34829822

2021

Subchondral Bone Microarchitectural and Mineral Properties and Expression of Key Degradative Proteinases by Chondrocytes in Human Hip Osteoarthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Yunfei Li,Yulia Liem,Zaitunnatakhin Zamli,Niall Sullivan,Enrico Dall'Ara,Haroon Ahmed,Grace Matilda Sellers,Ashley Blom,Mohammed Sharif

Molecular and cellular biochemistry 476:3623-3633 PubMed34046827

2021

Circ_0020093 ameliorates IL-1β-induced apoptosis and extracellular matrix degradation of human chondrocytes by upregulating SPRY1 via targeting miR-23b.

Applications

Unspecified application

Species

Unspecified reactive species

Mingli Feng,Lin Jing,Jingbo Cheng,Shuai An,Jiang Huang,Qi Yan

American journal of translational research 12:7953-7967 PubMed33437372

2020

INSR mediated by transcription factor KLF4 and DNA methylation ameliorates osteoarthritis progression via inactivation of JAK2/STAT3 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Wenzhou Liu,Yanbo Chen,Gang Zeng,Tao Yang,Weidong Song

Cell proliferation 54:e12941 PubMed33111436

2020

Acid-sensing ion channels regulate nucleus pulposus cell inflammation and pyroptosis via the NLRP3 inflammasome in intervertebral disc degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Kangcheng Zhao,Ran An,Qian Xiang,Gaocai Li,Kun Wang,Yu Song,Zhiwei Liao,Shuai Li,Wenbin Hua,Xiaobo Feng,Xinghuo Wu,Yukun Zhang,Abhirup Das,Cao Yang

Journal of cellular biochemistry 119:7959-7970 PubMed29236314

2018

IL-1β-induced miR-34a up-regulation inhibits Cyr61 to modulate osteoarthritis chondrocyte proliferation through ADAMTS-4.

Applications

Unspecified application

Species

Unspecified reactive species

Bo Yang,Jiangdong Ni,Hui Long,Jun Huang,Cheng Yang,Xianzhe Huang

Cellular physiology and biochemistry : internation 46:1693-1703 PubMed29694979

2018

Promotion of Tumor Growth by ADAMTS4 in Colorectal Cancer: Focused on Macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Jianjun Chen,Yang Luo,Yong Zhou,Shaolan Qin,Yier Qiu,Ran Cui,Minhao Yu,Jun Qin,Ming Zhong

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-ADAMTS4 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADAMTS4 antibody (AB84792)

Western blot - Anti-ADAMTS4 antibody (AB84792)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Reconstitution

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (16)

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