Rabbit Polyclonal ADAMTS5 antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 199 publications.
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- Frontiers in bioengineering and biotechnology 11:13014302023Liquid platelet-rich fibrin produced via horizontal centrifugation decreases the inflammatory response and promotes chondrocyte regeneration .Applications:Unspecified applicationReactive species:Unspecified reactive speciesHuimin Li,Ting Xia,Hao Zeng,Yun Qiu,Yan Wei,Yihong Cheng,Yulan Wang,Xiaoxin Zhang,Jin Ke,Richard Miron,Qing HePubMed 38144541
- Journal of orthopaedic surgery and research 18:9162023Inhibition of miR-96-5p alleviates intervertebral disc degeneration by regulating the peroxisome proliferator-activated receptor γ/nuclear factor-kappaB pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXusheng Li,Qian Hou,Wenqi Yuan,Xuehua Zhan,Haifeng YuanPubMed 38041147
- Arthritis research & therapy 25:2302023Resatorvid alleviates experimental inflammatory TMJOA by restraining chondrocyte pyroptosis and synovial inflammation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXin Liu,Huimin Li,Yaping Feng,Huilin Guo,Yingjie Li,Jin Ke,Xing LongPubMed 38031141
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology 37:e233032023Macrophage migration inhibitory factor (MIF) promotes intervertebral disc degeneration through the NF-κB pathway, and the MIF inhibitor CPSI-1306 alleviates intervertebral disc degeneration in a mouse model.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYejin Zhang,Lin Zheng,Jiawei Fang,Kainan Ni,Xingyu Hu,Lin Ye,Hehuan Lai,Tao Yang,Zhenzhong Chen,Dengwei HePubMed 37983963
- Journal of orthopaedic surgery and research 18:7842023PLXNC1 interference alleviates the inflammatory injury, apoptosis and extracellular matrix degradation of IL-1β-exposed chondrocytes via suppressing GRP78 expression.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNan Meng,Lingwei Mao,Qinyi Jiang,Jishan Yuan,Linjuan Liu,Lei WangPubMed 37853395
- Journal of nanobiotechnology 21:3502023Programmable DNA hydrogel provides suitable microenvironment for enhancing autophagy-based therapies in intervertebral disc degeneration treatment.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSong Qingxin,Jiang Kai,Zheng Dandan,Jin Linyu,Chen Xiuyuan,Feng Yubo,Wang Kun,Han Yingchao,Chen Hao,Song Jie,Chen Zhi,Shen HongxingPubMed 37759249
- International immunopharmacology 124:1109482023PP2 alleviates the progression of osteoarthritis by inhibiting Wnt/β-catenin and activating TGF-β/Smad signaling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHao Zhang,Chuanchuan Zheng,Wei Chen,Xiaoqiang Li,Jinshu Wang,Taikun Wang,Qi Zhao,Hao Huang,Yiting Li,Chengliang Yang,Kegong Xie,Shengcai Pan,Binghao Wang,Chong Wang,Yujin Tang,Kai Li,Jia Liu,Liqiang WangPubMed 37774483
- Clinical and translational medicine 13:e14152023Circular RNA circARPC1B functions as a stabilisation enhancer of Vimentin to prevent high cholesterol-induced articular cartilage degeneration.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJiarui Li,Xiang Li,Shengji Zhou,Yuxin Wang,Tiantian Ying,Quan Wang,Yizheng Wu,Fengchao ZhaoPubMed 37740460
- Journal of cellular physiology 238:2668-26782023Loss of miR-204 and miR-211 shifts osteochondral balance and causes temporomandibular joint osteoarthritis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJian Huang,Yumei Lai,Jun Li,Lan ZhaoPubMed 37697972
- Advanced healthcare materials 12:e23013372023Nucleus Pulposus-Targeting Nanocarriers Facilitate Mirna-Based Therapeutics for Intervertebral Disc Degeneration.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhonghui Chen,Zhong Liao,Ming Liu,Fengfei Lin,Shunyou Chen,Geng Wang,Zhong Zheng,Boling Liu,Chaoxiong Li,Zheqiang Wang,Tianlai Chen,Hongzhe Huang,Qi Liao,Weiliang CuiPubMed 37625164
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 98.98% PBS, 1% BSA- Form
Liquid
- Clonality
Polyclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Mouse | Tested |
| Rat | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/250 | Notes ab41037 appears to detect the 73kDa cleaved form of ADAMTS5. The precursor of this secreted protein is cleaved at a furin cleavage site by a furin endopeptidase. |
Species Rat | Dilution info 1/250 | Notes ab41037 appears to detect the 73kDa cleaved form of ADAMTS5. The precursor of this secreted protein is cleaved at a furin cleavage site by a furin endopeptidase. |
Species Human | Dilution info 1/250 | Notes ab41037 appears to detect the 73kDa cleaved form of ADAMTS5. The precursor of this secreted protein is cleaved at a furin cleavage site by a furin endopeptidase. |
Associated Products
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Target data
Function
Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN (PubMed:16133547, PubMed:18992360). Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration (By similarity). Participates in development of brown adipose tissue and browning of white adipose tissue (By similarity). Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection.
Alternative names
A disintegrin and metalloproteinase with thrombospondin motifs 5, ADAM-TS 5, ADAM-TS5, ADAMTS-5, A disintegrin and metalloproteinase with thrombospondin motifs 11, ADMP-2, Aggrecanase-2, ADAM-TS 11, ADAMTS-11, ADAMTS5, ADAMTS11, ADMP2
Recommended products
Rabbit Polyclonal ADAMTS5 antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 199 publications.
Alternative names
A disintegrin and metalloproteinase with thrombospondin motifs 5, ADAM-TS 5, ADAM-TS5, ADAMTS-5, A disintegrin and metalloproteinase with thrombospondin motifs 11, ADMP-2, Aggrecanase-2, ADAM-TS 11, ADAMTS-11, ADAMTS5, ADAMTS11, ADMP2
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 98.98% PBS, 1% BSA- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Purification technique
Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Product promise
Tested
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Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
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3 product images
Western blot - Anti-ADAMTS5 antibody (ab41037)
ab41037 appears to detect at 73kDa cleaved form of ADAMTS5. The precursor of this secreted protein is cleaved at a furin cleavage site by a furin endopeptidase.
All lanes: Western blot - Anti-ADAMTS5 antibody (ab41037) at 1/250 dilution
Lane 1: Western blot - NIH/3T3 whole cell lysate (NIH/3T3 whole cell lysate ab7179) at 10 µg
Lane 2: MEF1 (Mouse embryonic fibroblast cell line) Whole Cell Lysate at 10 µg
Lane 3: Brain (Mouse) Tissue Lysate at 10 µg
Lane 4: Liver (Mouse) Tissue Lysate - normal tissue at 10 µg
Lane 5: Testis (Mouse) Tissue Lysate - normal tissue at 10 µg
Lane 6: Spinal Cord (Mouse) Tissue Lysate at 10 µg
Lane 7: Ovary (Mouse) Tissue Lysate - normal tissue at 10 µg
Lane 8: PC12 (Rat adrenal pheochromocytoma cell line) Whole Cell Lysate at 10 µg
Lane 9: Brain (Rat) Tissue Lysate - normal tissue at 10 µg
Lane 10: Liver (Rat) Tissue Lysate at 10 µg
SecondaryAll lanes: IRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/10000 dilution
Performed under reducing conditions.
Predicted band size: 102 kDa
Observed band size: 73 kDa
Western blot - Anti-ADAMTS5 antibody (ab41037)
ab41037 appears to detect a 73kDa cleaved form of ADAMTS5. The precursor of this secreted protein is cleaved at a furin cleavage site by a furin endopeptidase. The doublet observed in human uterus lysate is possibly due to glycosylation.
All lanes: Western blot - Anti-ADAMTS5 antibody (ab41037) at 1/250 dilution
Lane 1: Human placenta tissue lysate - total protein (ab29745) at 10 µg
Lane 2: Western blot - Mouse placenta normal tissue lysate - total protein (Mouse placenta normal tissue lysate - total protein ab29139) at 10 µg
Lane 3: Uterus (Human) Whole Cell Lysate - normal tissue at 10 µg
Lane 4: HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate at 10 µg
SecondaryAll lanes: IRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/10000 dilution
Performed under reducing conditions.
Predicted band size: 102 kDa
Observed band size: 27 kDa, 73 kDa
Western blot - Anti-ADAMTS5 antibody (ab41037)
ab41037 appears to detect at 73kDa cleaved form of ADAMTS5. The precursor of this secreted protein is cleaved at a furin cleavage site by a furin endopeptidase.
All lanes: Western blot - Anti-ADAMTS5 antibody (ab41037) at 1 µg/mL
Lane 1: HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate at 10 µg
Lane 2: MEF1 (Mouse embryonic fibroblast cell line) Whole Cell Lysate at 10 µg
Lane 3: PC12 (Rat adrenal pheochromocytoma cell line) Whole Cell Lysate at 10 µg
SecondaryAll lanes: Western blot - Goat Anti-Rabbit IgG H&L (HRP) (Goat Anti-Rabbit IgG H&L (HRP) ab97051) at 1/10000 dilution
Developed using the ECL technique.
Performed under reducing conditions.
Predicted band size: 102 kDa
Observed band size: 55 kDa, 73 kDa
Exposure time: 12min
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