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AB50647

Anti-ADAMTS6 antibody

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(1 Publication)

Rabbit Polyclonal ADAMTS6 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human A disintegrin and metalloproteinase with thrombospondin motifs 6.

View Alternative Names

A disintegrin and metalloproteinase with thrombospondin motifs 6, ADAM-TS 6, ADAM-TS6, ADAMTS-6, ADAMTS6

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human A disintegrin and metalloproteinase with thrombospondin motifs 6. The exact immunogen used to generate this antibody is proprietary information.

Q9UKP5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 2.9% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ADAMTS6 is an enzyme that belongs to the ADAMTS (A Disintegrin And Metalloproteinase with Thrombospondin Motifs) family involved in processing and remodeling the extracellular matrix. It acts as a metalloproteinase utilizing metalloproteinase activity to cleave specific peptide bonds in target substrates. This enzyme with an approximate molecular mass of 230 kDa is expressed in various tissues including heart skeletal muscle and placenta. Other names for ADAMTS6 include ADAMTS-6 and a disintegrin-like and metalloproteinase with thrombospondin type 1 motif 6.
Biological function summary

ADAMTS6 modulates the matrix degradation and is involved in assembling the extracellular matrix. It plays a role in tissue development and repair by influencing cell-matrix interactions. ADAMTS6 functions as part of the ADAMTS enzyme family not forming large complexes but often acting in concert with other family members. Its activity affects processes like angiogenesis and cell migration by controlling the availability and organization of matrix components.

Pathways

ADAMTS6 participates in the extracellular matrix organization pathway and influences the inflammation pathway. The enzyme's activity helps regulate matrix integrity and turnover impacting ECM-related signaling pathways. It shares functional networks with proteins like collagen and fibronectin essential for maintaining matrix structure and signaling. ADAMTS6 interactions with these proteins modulate cellular behaviors important for wound healing.

ADAMTS6 has associations with musculoskeletal disorders such as osteoarthritis and cardiovascular diseases. Aberrant expression or dysfunction of ADAMTS6 impacts extracellular matrix dynamics potentially contributing to disease mechanisms. It often displays relationships with proteins like ADAMTS1 in these conditions which similarly modulates extracellular matrix properties. Understanding its role aids in identifying molecular targets for therapeutic interventions in related disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information A disintegrin and metalloproteinase with thrombospondin motifs 6
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

BMC genomics 12:618 PubMed22185580

2011

Identification of proprotein convertase substrates using genome-wide expression correlation analysis.

Applications

WB

Species

Mouse

Hannu Turpeinen,Sampo Kukkurainen,Kati Pulkkinen,Timo Kauppila,Kalle Ojala,Vesa P Hytönen,Marko Pesu
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Product promise

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