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AB201083

Anti-ADAMTS7 antibody

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(1 Publication)

Rabbit Polyclonal ADAMTS7 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human A disintegrin and metalloproteinase with thrombospondin motifs 7 aa 150-250.

View Alternative Names

A disintegrin and metalloproteinase with thrombospondin motifs 7, ADAM-TS 7, ADAM-TS7, ADAMTS-7, ADAMTS7

1 Images
Western blot - Anti-ADAMTS7 antibody (AB201083)
  • WB

Supplier Data

Western blot - Anti-ADAMTS7 antibody (AB201083)

All lanes:

Western blot - Anti-ADAMTS7 antibody (ab201083)

Lane 1:

HEK293T whole cell lysate

Lane 2:

Mouse Raw 264.7 whole cell lysate

Lane 3:

Rat H9C2 whole cell lysate

Predicted band size: 184 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human A disintegrin and metalloproteinase with thrombospondin motifs 7 aa 150-250. The exact immunogen used to generate this antibody is proprietary information.

Q9UKP4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab201083 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage buffer
pH: 7.3 Preservative: 0.05% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ADAMTS7 also known as ADAM Metallopeptidase with Thrombospondin Type 1 Motif 7 is an enzyme with a molecular mass of approximately 180 kDa. This protein is part of the ADAMTS family characterized by a disintegrin and metalloproteinase with thrombospondin motifs. ADAMTS7 is expressed mainly in the human kidney liver and skeletal muscle tissues. This protein plays a significant role in the degradation and remodeling of the extracellular matrix mediating processes such as protein processing and extracellular matrix assembly.
Biological function summary

ADAMTS7 functions as an important regulatory enzyme involved in the processing of cartilage oligomeric matrix protein (COMP). This process impacts the integrity and function of cartilage suggesting its vital role in maintaining cartilage homeostasis. Though it does not form part of a larger complex ADAMTS7 interacts closely with extracellular matrix components modulating cellular processes connected to tissue organization and structural integrity.

Pathways

ADAMTS7 is integral to the extracellular matrix organization pathway impacting its degradation and synthesis. It is also associated with the focal adhesion pathway which is critical for cell adhesion migration and signal transduction. In these pathways ADAMTS7 acts alongside proteins such as integrins and other matrix metalloproteinases coordinating cellular responses to mechanical and chemical stimuli through direct protein interactions.

ADAMTS7 has a connection to atherosclerosis and osteoarthritis. In atherosclerosis ADAMTS7 influences the remodeling of vascular tissues with effects on arterial stiffness and plaque stability. It interacts with proteins like low-density lipoprotein receptor-related protein 1 (LRP1) affecting lipid accumulation and inflammatory responses. In osteoarthritis ADAMTS7 contributes to cartilage degradation linking with other matrix-degrading enzymes to influence the progression of joint degeneration and inflammation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Metalloprotease (PubMed : 16585064, PubMed : 39672391). Was previously shown to degrade COMP (PubMed : 16585064). However, a later study found no activity against COMP (PubMed : 39672391).
See full target information A disintegrin and metalloproteinase with thrombospondin motifs 7
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in pharmacology 13:862085 PubMed35370630

2022

Pterostilbene in Combination With Mitochondrial Cofactors Improve Mitochondrial Function in Cellular Models of Mitochondrial Diseases.

Applications

Unspecified application

Species

Unspecified reactive species

Juan M Suárez-Rivero,Carmen J Pastor-Maldonado,Ana Romero-González,David Gómez-Fernandez,Suleva Povea-Cabello,Mónica Álvarez-Córdoba,Irene Villalón-García,Marta Talaverón-Rey,Alejandra Suárez-Carrillo,Manuel Munuera-Cabeza,José A Sánchez-Alcázar
View all publications
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Product promise

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