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AB222383

Anti-ADAMTS7 antibody

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(1 Publication)

Rabbit Polyclonal ADAMTS7 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human A disintegrin and metalloproteinase with thrombospondin motifs 7 aa 1300-1400.

View Alternative Names

A disintegrin and metalloproteinase with thrombospondin motifs 7, ADAM-TS 7, ADAM-TS7, ADAMTS-7, COMPase, ADAMTS7

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-ADAMTS7 antibody (AB222383)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-ADAMTS7 antibody (AB222383)

PFA fixed / Triton X-100 permeabilized U-2 OS (human bone osteosarcoma epithelial cell line) cells stained for ADAMTS7 (green) using ab222383 at 4 μg/ml in ICC/IF.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human A disintegrin and metalloproteinase with thrombospondin motifs 7 aa 1300-1400. The exact immunogen used to generate this antibody is proprietary information.

Q9UKP4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ADAMTS7 also known as ADAM Metallopeptidase with Thrombospondin Type 1 Motif 7 is an enzyme with a molecular mass of approximately 180 kDa. This protein is part of the ADAMTS family characterized by a disintegrin and metalloproteinase with thrombospondin motifs. ADAMTS7 is expressed mainly in the human kidney liver and skeletal muscle tissues. This protein plays a significant role in the degradation and remodeling of the extracellular matrix mediating processes such as protein processing and extracellular matrix assembly.
Biological function summary

ADAMTS7 functions as an important regulatory enzyme involved in the processing of cartilage oligomeric matrix protein (COMP). This process impacts the integrity and function of cartilage suggesting its vital role in maintaining cartilage homeostasis. Though it does not form part of a larger complex ADAMTS7 interacts closely with extracellular matrix components modulating cellular processes connected to tissue organization and structural integrity.

Pathways

ADAMTS7 is integral to the extracellular matrix organization pathway impacting its degradation and synthesis. It is also associated with the focal adhesion pathway which is critical for cell adhesion migration and signal transduction. In these pathways ADAMTS7 acts alongside proteins such as integrins and other matrix metalloproteinases coordinating cellular responses to mechanical and chemical stimuli through direct protein interactions.

ADAMTS7 has a connection to atherosclerosis and osteoarthritis. In atherosclerosis ADAMTS7 influences the remodeling of vascular tissues with effects on arterial stiffness and plaque stability. It interacts with proteins like low-density lipoprotein receptor-related protein 1 (LRP1) affecting lipid accumulation and inflammatory responses. In osteoarthritis ADAMTS7 contributes to cartilage degradation linking with other matrix-degrading enzymes to influence the progression of joint degeneration and inflammation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Metalloprotease that may play a role in the degradation of COMP.
See full target information A disintegrin and metalloproteinase with thrombospondin motifs 7
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of biological chemistry 291:8309-23 PubMed26872972

2016

Endoplasmic Reticulum-resident Heat Shock Protein 90 (HSP90) Isoform Glucose-regulated Protein 94 (GRP94) Regulates Cell Polarity and Cancer Cell Migration by Affecting Intracellular Transport.

Applications

Unspecified application

Species

Unspecified reactive species

Suman Ghosh,Heather E Shinogle,Nadezhda A Galeva,Rick T Dobrowsky,Brian S J Blagg
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Product promise

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