Rabbit Polyclonal ADAMTS9 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human ADAMTS9 aa 150-300.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human ADAMTS9 aa 150-300. The exact immunogen used to generate this antibody is proprietary information. Database link Q9P2N4
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/20.00000 - 1/50.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Associated Products
Select an associated product type
1 product for Alternative Product
Target data
Function
Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428-Glu-|-Ala-1429' site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos.
Alternative names
KIAA1312, ADAMTS9, A disintegrin and metalloproteinase with thrombospondin motifs 9, ADAM-TS 9, ADAM-TS9, ADAMTS-9
Recommended products
Rabbit Polyclonal ADAMTS9 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human ADAMTS9 aa 150-300.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human ADAMTS9 aa 150-300. The exact immunogen used to generate this antibody is proprietary information. Database link Q9P2N4
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The ADAMTS9 protein also known as A Disintegrin and Metalloproteinase with Thrombospondin motifs 9 plays a mechanical role as a metalloproteinase enzyme. It features a molecular weight of approximately 193 kDa. ADAMTS9 is expressed in various tissues including the heart pancreas and kidney among others. This protein undergoes post-translational modifications that impact its mechanical functions offering unique regulation mechanisms for tissue remodeling and extracellular matrix degradation.
- Biological function summary
ADAMTS9 influences processes associated with maintaining extracellular matrix integrity and remodeling. It participates in the cleavage of proteoglycans hence modulating cellular environments. This protein does not typically form large complexes but it interacts with substrates that are part of the complex networks found in connective tissues. Its enzymatic activity is subject to intervention by specific inhibitors which can significantly affect tissue homeostasis.
- Pathways
ADAMTS9 is involved in the TGF-beta signaling and inflammatory response pathways. The TGF-beta signaling pathway is integral to regulating cellular growth and differentiation. In the inflammatory response ADAMTS9 interacts with proteins like aggrecan playing a part in inflammation-related tissue devastation. These pathways demonstrate the multifunctional nature of ADAMTS9 in cellular and physiological contexts.
- Associated diseases and disorders
ADAMTS9 is notably associated with arthritis and cancer progression. In arthritis the enzymatic activity leads to tissue degradation by breaking down cartilage components linking it to disease progression. In tumors its altered expression may influence cancer cell invasion and metastasis. In these conditions ADAMTS9 interacts with proteins such as versican contributing to pathological changes in tissue architecture and cellular behavior.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
4 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADAMTS9 antibody (ab224132)
Paraffin-embedded human placenta tissue stained for ADAMTS9 using ab224132 at 1/20 dilution in immunohistochemical analysis.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADAMTS9 antibody (ab224132)
Paraffin-embedded human kidney tissue stained for ADAMTS9 using ab224132 at 1/20 dilution in immunohistochemical analysis.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADAMTS9 antibody (ab224132)
Paraffin-embedded human duodenum tissue stained for ADAMTS9 using ab224132 at 1/20 dilution in immunohistochemical analysis.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADAMTS9 antibody (ab224132)
Paraffin-embedded human cerebellum tissue stained for ADAMTS9 using ab224132 at 1/20 dilution in immunohistochemical analysis.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com