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AB97603

Anti-ADAMTSL2 antibody

4

(1 Review)

|

(3 Publications)

Rabbit Polyclonal ADAMTSL2 antibody. Suitable for WB and reacts with Human, Mouse samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ADAMTSL2 aa 750-950.

View Alternative Names

KIAA0605, ADAMTSL2, ADAMTS-like protein 2, ADAMTSL-2

2 Images
Western blot - Anti-ADAMTSL2 antibody (AB97603)
  • WB

Supplier Data

Western blot - Anti-ADAMTSL2 antibody (AB97603)

Samples were separated by 7.5% SDS PAGE.

All lanes:

Western blot - Anti-ADAMTSL2 antibody (ab97603) at 1/500 dilution

Lane 1:

HepG2 whole cell extract and conditioned medium at 30 µg

Lane 2:

HepG2 whole cell extract with conditioned medium at 30 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG antibody

Predicted band size: 105 kDa

false

Western blot - Anti-ADAMTSL2 antibody (AB97603)
  • WB

Supplier Data

Western blot - Anti-ADAMTSL2 antibody (AB97603)

Samples were separated by 5% SDS PAGE. The signal was developed with Trident ECL plus-Enhanced.

All lanes:

Western blot - Anti-ADAMTSL2 antibody (ab97603) at 1/1000 dilution

Lane 1:

C2Cl2 whole cell lysate at 30 µg

Lane 2:

differentiated C2Cl2 whole cell lysate at 30 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG antibody

Predicted band size: 105 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human ADAMTSL2 aa 750-950. The exact immunogen used to generate this antibody is proprietary information.

Q86TH1

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  • 3
  • 1
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ADAMTSL2 also known as ADAMTS-like 2 is a secreted glycoprotein that belongs to the family of ADAMTS-like proteins. The molecular mass of this protein is approximately 65 kDa. ADAMTSL2 expresses predominantly in connective tissues and various organs including the skin cartilage and lung tissues. It shares structural similarities with other members of the ADAMTS family but lacks the protease domain which is essential for proteolytic activity in related proteins.
Biological function summary

ADAMTSL2 plays an important role in extracellular matrix organization and assembly. It is not part of a known complex but it interacts closely with fibrillin-1 influencing the regulation of microfibril architecture. The presence of ADAMTSL2 can impact the deposition and maintenance of elastic fibers contributing significantly to the structural integrity of connective tissues.

Pathways

The presence of ADAMTSL2 is integral to the TGF-beta signaling pathway and extracellular matrix-receptor interaction pathway. It modulates the bioavailability of latent TGF-beta by interacting with fibrillin-1 and indirectly influencing the activity of proteins like LTBP4. These interactions play a role in maintaining proper tissue architecture and cellular functions by mediating signaling cascades essential for tissue repair and homeostasis.

Mutations in the ADAMTSL2 gene associate with geleophysic dysplasia a rare skeletal disorder characterized by short stature and heart valve abnormalities. The connection to fibrillin-1 further links ADAMTSL2 to disorders such as Marfan syndrome though through indirect pathways rather than direct genetic links. The involvement of other proteins in this process such as LTBP4 and fibrillin-1 helps elucidate the molecular mechanisms underlying these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information ADAMTSL2
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Developmental biology 488:120-130 PubMed35644252

2022

TGFβ signaling is required for sclerotome resegmentation during development of the spinal column in Gallus gallus.

Applications

Unspecified application

Species

Unspecified reactive species

Sade W Clayton,Allyson Angermeier,Jacob E Halbrooks,Ronisha McCardell,Rosa Serra

Cell reports 29:1832-1847.e8 PubMed31722201

2019

Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Ross Dobie,John R Wilson-Kanamori,Beth E P Henderson,James R Smith,Kylie P Matchett,Jordan R Portman,Karolina Wallenborg,Simone Picelli,Anna Zagorska,Swetha V Pendem,Thomas E Hudson,Minnie M Wu,Grant R Budas,David G Breckenridge,Ewen M Harrison,Damian J Mole,Stephen J Wigmore,Prakash Ramachandran,Chris P Ponting,Sarah A Teichmann,John C Marioni,Neil C Henderson

Cell reports 25:3086-3098.e3 PubMed30540941

2018

TMED2 Potentiates Cellular IFN Responses to DNA Viruses by Reinforcing MITA Dimerization and Facilitating Its Trafficking.

Applications

Unspecified application

Species

Unspecified reactive species

Ming-Shun Sun,Jie Zhang,Li-Qun Jiang,Yi-Xi Pan,Jiao-Yi Tan,Fang Yu,Lin Guo,Lei Yin,Chao Shen,Hong-Bing Shu,Yu Liu
View all publications
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Product promise

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