Rabbit Polyclonal ADAMTSL2 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ADAMTSL2 aa 750-950.
Images
Publications
Filter by
- Developmental biology 488:120-1302022TGFβ signaling is required for sclerotome resegmentation during development of the spinal column in Gallus gallus.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSade W Clayton,Allyson Angermeier,Jacob E Halbrooks,Ronisha McCardell,Rosa SerraPubMed 35644252
- Cell reports 29:1832-1847.e82019Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRoss Dobie,John R Wilson-Kanamori,Beth E P Henderson,James R Smith,Kylie P Matchett,Jordan R Portman,Karolina Wallenborg,Simone Picelli,Anna Zagorska,Swetha V Pendem,Thomas E Hudson,Minnie M Wu,Grant R Budas,David G Breckenridge,Ewen M Harrison,Damian J Mole,Stephen J Wigmore,Prakash Ramachandran,Chris P Ponting,Sarah A Teichmann,John C Marioni,Neil C HendersonPubMed 31722201
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human ADAMTSL2 aa 750-950. The exact immunogen used to generate this antibody is proprietary information. Database link Q86TH1
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info - | Notes - |
Target data
Alternative names
KIAA0605, ADAMTSL2, ADAMTS-like protein 2, ADAMTSL-2
Recommended products
Rabbit Polyclonal ADAMTSL2 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ADAMTSL2 aa 750-950.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human ADAMTSL2 aa 750-950. The exact immunogen used to generate this antibody is proprietary information. Database link Q86TH1
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ADAMTSL2 also known as ADAMTS-like 2 is a secreted glycoprotein that belongs to the family of ADAMTS-like proteins. The molecular mass of this protein is approximately 65 kDa. ADAMTSL2 expresses predominantly in connective tissues and various organs including the skin cartilage and lung tissues. It shares structural similarities with other members of the ADAMTS family but lacks the protease domain which is essential for proteolytic activity in related proteins.
- Biological function summary
ADAMTSL2 plays an important role in extracellular matrix organization and assembly. It is not part of a known complex but it interacts closely with fibrillin-1 influencing the regulation of microfibril architecture. The presence of ADAMTSL2 can impact the deposition and maintenance of elastic fibers contributing significantly to the structural integrity of connective tissues.
- Pathways
The presence of ADAMTSL2 is integral to the TGF-beta signaling pathway and extracellular matrix-receptor interaction pathway. It modulates the bioavailability of latent TGF-beta by interacting with fibrillin-1 and indirectly influencing the activity of proteins like LTBP4. These interactions play a role in maintaining proper tissue architecture and cellular functions by mediating signaling cascades essential for tissue repair and homeostasis.
- Associated diseases and disorders
Mutations in the ADAMTSL2 gene associate with geleophysic dysplasia a rare skeletal disorder characterized by short stature and heart valve abnormalities. The connection to fibrillin-1 further links ADAMTSL2 to disorders such as Marfan syndrome though through indirect pathways rather than direct genetic links. The involvement of other proteins in this process such as LTBP4 and fibrillin-1 helps elucidate the molecular mechanisms underlying these conditions.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
Western blot - Anti-ADAMTSL2 antibody (ab97603)
7.5% SDS PAGE
All lanes: Western blot - Anti-ADAMTSL2 antibody (ab97603) at 1/500 dilution
All lanes: H1299 whole cell lysate at 30 µg
Predicted band size: 104 kDa
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com