Anti-ADAT2 antibody
3
(2 Reviews)
|
(2 Publications)
Rabbit Polyclonal ADAT2 antibody. Suitable for IHC-P, ICC and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ADAT2 aa 1-100.
View Alternative Names
DEADC1, ADAT2, tRNA-specific adenosine deaminase 2, Deaminase domain-containing protein 1, tRNA-specific adenosine-34 deaminase subunit ADAT2
- ICC
Unknown
Immunocytochemistry - Anti-ADAT2 antibody (AB122280)
Immunocytochemistry/immunofluorescence analysis of human cell line HeLa labelling with ab122280 at 2 μg/mL shows localization to cytosol & the Golgi apparatus.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADAT2 antibody (AB122280)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human kidney tissue labelling ADAT2 with ab122280 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADAT2 antibody (AB122280)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human stomach tissue labelling ADAT2 with ab122280 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADAT2 antibody (AB122280)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human cerebellum tissue labelling ADAT2 with ab122280 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADAT2 antibody (AB122280)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human skin tissue labelling ADAT2 with ab122280 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
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Supplementary information
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Biological function summary
ADAT2 works as part of the ADAT complex that includes ADAT3. This complex specifically targets anticodon regions of tRNAs. The conversion of adenosine to inosine by ADAT2 changes the reading of certain codons allowing for proper interpretation of genetic code elements important for cell function and viability. ADAT2’s activity impacts the modification process essential for accurate protein translation.
Pathways
Four important mechanisms involve ADAT2 in RNA metabolic processes. It plays an integral role in the post-transcriptional modification of RNA particularly within the tRNA maturation pathway. This pathway collaborates with proteins such as ADAT3 and their interaction governs fidelity in transcribing genetic information into proteins. The editing by ADAT2 ensures that tRNA molecules can correctly interpret codons during translation.
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Publications (2)
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Cell stem cell 30:300-311.e11 PubMed36764294
2023
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Evolution; international journal of organic evolution 74:2451-2464 PubMed32989734
2020
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