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AB127019

Anti-ADCY2 antibody

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(1 Publication)

Rabbit Polyclonal ADCY2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ADCY2 aa 850 to C-terminus.

View Alternative Names

KIAA1060, ADCY2, Adenylate cyclase type 2, ATP pyrophosphate-lyase 2, Adenylate cyclase type II, Adenylyl cyclase 2

1 Images
Western blot - Anti-ADCY2 antibody (AB127019)
  • WB

Unknown

Western blot - Anti-ADCY2 antibody (AB127019)

7.5% SDS PAGE

All lanes:

Western blot - Anti-ADCY2 antibody (ab127019) at 1/1000 dilution

All lanes:

IMR32 cell lysate at 30 µg

Predicted band size: 124 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human ADCY2 aa 850 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q08462

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ADCY2 also known as Adenylate Cyclase 2 is an enzyme involved in the synthesis of cyclic adenosine monophosphate (cAMP) from ATP. ADCY2 with a molecular mass of approximately 140 kDa plays an important role in signal transduction. This protein is highly expressed in the brain particularly in areas such as the cortex and the hippocampus. As part of the adenylate cyclase family ADCY2 is one of several isoforms that share similar functions in different tissues.
Biological function summary

ADCY2 contributes to various cellular processes by converting ATP to cAMP an important secondary messenger in cells. It forms part of the larger signalosome complex and interacts with G-protein coupled receptors. By regulating cAMP levels ADCY2 influences processes such as neurotransmitter release and long-term memory formation. It also modulates the activity of protein kinase A impacting several downstream signaling pathways.

Pathways

ADCY2 is integral to G-protein coupled receptor signaling and the cAMP signaling pathway. This pathway plays a fundamental role in transmitting extracellular signals to intracellular responses. ADCY2's activity is closely linked with other proteins like G-proteins and phosphodiesterases which help regulate cAMP levels and downstream cellular responses. In some pathways ADCY2 interacts synergistically with the protein CREB which orchestrates gene transcription in response to cAMP levels.

ADCY2 has been associated with neurological conditions such as depression and schizophrenia. Altered expression or function of ADCY2 can lead to imbalances in cAMP signaling which affect mood regulation and cognitive functions. The protein CREB which ADCY2 influences is also implicated in mood disorders and cognitive impairments. Understanding ADCY2's role in these conditions aids in developing targeted therapies aimed at modulating its expression or activity.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed : 15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity).
See full target information ADCY2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Heliyon 10:e40405 PubMed39687103

2024

Establishment of prognostic risk model related to disulfidptosis and immune infiltration in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Zhe Xu,Chong Pang,Xundi Xu
View all publications
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Product promise

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