Rabbit Polyclonal ADCY2 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human ADCY2 aa 850 to C-terminus.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human ADCY2 aa 850 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q08462
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Rat | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Associated Products
Select an associated product type
1 product for Alternative Product
Target data
Function
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity).
Alternative names
KIAA1060, ADCY2, Adenylate cyclase type 2, ATP pyrophosphate-lyase 2, Adenylate cyclase type II, Adenylyl cyclase 2
Recommended products
Rabbit Polyclonal ADCY2 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human ADCY2 aa 850 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human ADCY2 aa 850 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q08462
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ADCY2 also known as Adenylate Cyclase 2 is an enzyme involved in the synthesis of cyclic adenosine monophosphate (cAMP) from ATP. ADCY2 with a molecular mass of approximately 140 kDa plays an important role in signal transduction. This protein is highly expressed in the brain particularly in areas such as the cortex and the hippocampus. As part of the adenylate cyclase family ADCY2 is one of several isoforms that share similar functions in different tissues.
- Biological function summary
ADCY2 contributes to various cellular processes by converting ATP to cAMP an important secondary messenger in cells. It forms part of the larger signalosome complex and interacts with G-protein coupled receptors. By regulating cAMP levels ADCY2 influences processes such as neurotransmitter release and long-term memory formation. It also modulates the activity of protein kinase A impacting several downstream signaling pathways.
- Pathways
ADCY2 is integral to G-protein coupled receptor signaling and the cAMP signaling pathway. This pathway plays a fundamental role in transmitting extracellular signals to intracellular responses. ADCY2's activity is closely linked with other proteins like G-proteins and phosphodiesterases which help regulate cAMP levels and downstream cellular responses. In some pathways ADCY2 interacts synergistically with the protein CREB which orchestrates gene transcription in response to cAMP levels.
- Associated diseases and disorders
ADCY2 has been associated with neurological conditions such as depression and schizophrenia. Altered expression or function of ADCY2 can lead to imbalances in cAMP signaling which affect mood regulation and cognitive functions. The protein CREB which ADCY2 influences is also implicated in mood disorders and cognitive impairments. Understanding ADCY2's role in these conditions aids in developing targeted therapies aimed at modulating its expression or activity.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
Western blot - Anti-ADCY2 antibody (ab127019)
7.5% SDS PAGE
All lanes: Western blot - Anti-ADCY2 antibody (ab127019) at 1/1000 dilution
All lanes: IMR32 cell lysate at 30 µg
Predicted band size: 124 kDa
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com