AB151470

Anti-ADCY2 antibody

Name: Anti-ADCY2 antibody (ab151470) | Abcam
Brand: Abcam Limited
SKU: AB151470
Rating: 4 (1 reviews)

(1 Review)

(3 Publications)

Rabbit Polyclonal ADCY2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ADCY2 aa 400-600.

View Alternative Names

KIAA1060, ADCY2, Adenylate cyclase type 2, ATP pyrophosphate-lyase 2, Adenylate cyclase type II, Adenylyl cyclase 2

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADCY2 antibody (AB151470)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADCY2 antibody (AB151470)

Immunohistochemical analysis of paraffin-embedded OVCA tissue labeling ADCY2 with ab151470 at 1/250 dilution.

Unknown

Western blot - Anti-ADCY2 antibody (AB151470)

7.5% SDS PAGE

All lanes:

Western blot - Anti-ADCY2 antibody (ab151470) at 1/1000 dilution

All lanes:

IMR32 whole cell lysate at 30 µg

Predicted band size: 124 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human ADCY2 aa 400-600. The exact immunogen used to generate this antibody is proprietary information.

Q08462

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ADCY2 also known as Adenylate Cyclase 2 is an enzyme involved in the synthesis of cyclic adenosine monophosphate (cAMP) from ATP. ADCY2 with a molecular mass of approximately 140 kDa plays an important role in signal transduction. This protein is highly expressed in the brain particularly in areas such as the cortex and the hippocampus. As part of the adenylate cyclase family ADCY2 is one of several isoforms that share similar functions in different tissues.

Biological function summary

ADCY2 contributes to various cellular processes by converting ATP to cAMP an important secondary messenger in cells. It forms part of the larger signalosome complex and interacts with G-protein coupled receptors. By regulating cAMP levels ADCY2 influences processes such as neurotransmitter release and long-term memory formation. It also modulates the activity of protein kinase A impacting several downstream signaling pathways.

Pathways

ADCY2 is integral to G-protein coupled receptor signaling and the cAMP signaling pathway. This pathway plays a fundamental role in transmitting extracellular signals to intracellular responses. ADCY2's activity is closely linked with other proteins like G-proteins and phosphodiesterases which help regulate cAMP levels and downstream cellular responses. In some pathways ADCY2 interacts synergistically with the protein CREB which orchestrates gene transcription in response to cAMP levels.

ADCY2 has been associated with neurological conditions such as depression and schizophrenia. Altered expression or function of ADCY2 can lead to imbalances in cAMP signaling which affect mood regulation and cognitive functions. The protein CREB which ADCY2 influences is also implicated in mood disorders and cognitive impairments. Understanding ADCY2's role in these conditions aids in developing targeted therapies aimed at modulating its expression or activity.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed : 15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity).

See full target information ADCY2

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Biomolecules 12: PubMed35625651

2022

Preferential Expression of Ca-Stimulable Adenylyl Cyclase III in the Supraventricular Area, including Arrhythmogenic Pulmonary Vein of the Rat Heart.

Applications

Unspecified application

Species

Unspecified reactive species

Yosuke Okamoto,Naing Ye Aung,Masahiro Tanaka,Yuji Takeda,Daichi Takagi,Wataru Igarashi,Kuniaki Ishii,Mitsunori Yamakawa,Kyoichi Ono

Theranostics 11:5650-5674 PubMed33897873

2021

Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao Zhang,Keke Yu,Lifang Ma,Zijun Qian,Xiaoting Tian,Yayou Miao,Yongjie Niu,Xin Xu,Susu Guo,Yueyue Yang,Zhixian Wang,Xiangfei Xue,Chuanjia Gu,Wentao Fang,Jiayuan Sun,Yongchun Yu,Jiayi Wang

The Journal of cell biology 218:3861-3879 PubMed31488582

2019

New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells.

Applications

Unspecified application

Species

Unspecified reactive species

Laia Bassaganyas,Stephanie J Popa,Max Horlbeck,Claudia Puri,Sarah E Stewart,Felix Campelo,Anupama Ashok,Cristian M Butnaru,Nathalie Brouwers,Kartoosh Heydari,Jean Ripoche,Jonathan Weissman,David C Rubinsztein,Randy Schekman,Vivek Malhotra,Kevin Moreau,Julien Villeneuve

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ADCY2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADCY2 antibody (AB151470)

Western blot - Anti-ADCY2 antibody (AB151470)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

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