AB229671

Anti-Adenosine A2b Receptor/ADORA2B antibody

Name: Anti-Adenosine A2b Receptor/ADORA2B antibody (ab229671) | Abcam
Brand: Abcam Limited
SKU: AB229671
Price: 420 USD
Availability: InStock

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(8 Publications)

Rabbit Polyclonal Adenosine A2b Receptor/ADORA2B antibody. Suitable for IHC-P and reacts with Mouse, Rat samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human ADORA2B.

View Alternative Names

Adenosine receptor A2b, ADORA2B

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adenosine A2b Receptor/ADORA2B antibody (AB229671)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adenosine A2b Receptor/ADORA2B antibody (AB229671)

Paraffin-embedded rat brain tissue stained for Adenosine A2b Receptor/ADORA2B using ab229671 at 1/500 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adenosine A2b Receptor/ADORA2B antibody (AB229671)

Paraffin-embedded mouse brain tissue stained for Adenosine A2b Receptor/ADORA2B using ab229671 at 1/500 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat, Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human ADORA2B. The exact immunogen used to generate this antibody is proprietary information.

P29275

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "notRecommended", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "notRecommended", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Adenosine A2b Receptor (ADORA2B) is a member of the G-protein-coupled receptor family with alternative names including A2b Receptor and (A-2b). This receptor mediates its effects by binding adenosine a purine nucleoside found in various tissues. It has an approximate molecular weight of 36 kDa. ADORA2B is expressed in many tissues but shows larger expression in the colon bladder and lung. Its mechanical role involves activating adenylate cyclase through Gs protein coupling which increases intracellular cyclic AMP levels.

Biological function summary

The ADORA2B receptor plays a role in numerous physiological processes including immune response inflammation and response to hypoxia. It does not form part of a larger receptor complex; instead it acts independently. By modulating cAMP levels ADORA2B influences cellular responses affecting functions like smooth muscle relaxation and endothelial cell barrier function. This receptor is essential for regulating various biological rhythms and cellular stress responses.

Pathways

The ADORA2B receptor participates significantly in the adenosine signaling pathway and the hypoxia signaling pathway. In the adenosine signaling pathway ADORA2B interacts closely with proteins like adenylyl cyclase which are important for cAMP production. The receptor's activity can modulate the PKA (protein kinase A) pathway affecting downstream biological responses including the inflammatory and immune pathways.

ADORA2B has links to conditions such as asthma and ischemic injury. In asthma the receptor's role in promoting inflammation is significant and it interacts with proteins like cytokines involved in inflammatory processes. In ischemic injury ADORA2B is implicated due to its involvement in the body's response to low oxygen levels. It interacts with hypoxia-inducible factors in this context affecting cellular survival and adaptation mechanisms.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

See full target information ADORA2B

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Publications (8)

Recent publications for all applications. Explore the full list and refine your search

Journal of dental sciences 20:1681-1688 PubMed40654474

2025

Silencing miR-1291-LEFTY2 axis diminishes the myofibroblast activities and reactive oxygen species generation of fibrotic buccal mucosal fibroblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Ming-Yung Chou,Shih-Min Wang,Pei-Ling Hsieh,Yi-Wen Liao,Cheng-Chia Yu,Chang-Yi Tsai

Livers 4:15-30 PubMed39007013

2024

Translocation of Adenosine A2B Receptor to Mitochondria Influences Cytochrome P450 2E1 Activity after Acetaminophen Overdose.

Applications

Unspecified application

Species

Unspecified reactive species

Giselle Sanchez-Guerrero,David S Umbaugh,Abhay A Ramachandran,Antonio Artigues,Hartmut Jaeschke,Anup Ramachandran

Frontiers in physiology 15:1359357 PubMed38426208

2024

Alteration in the number, morphology, function, and metabolism of erythrocytes in high-altitude polycythemia.

Applications

Unspecified application

Species

Unspecified reactive species

Song Yu,Yi Ye,Tana Wuren,Hai Yi

Environmental toxicology 39:2487-2501 PubMed38174997

2024

ADORA2B, transcriptionally suppressing by MYC, promotes ferroptosis of chondrocytes via inhibition of the PI3K/Akt pathway in mice with osteoarthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Shen Li,Jiangbo Han,Jiongzhe Cao,Hong Han,Bin Lu,Tao Wen,Weiguo Bian

Purinergic signalling 20:371-384 PubMed37938538

2023

Modafinil exerts anti-inflammatory and anti-fibrotic effects by upregulating adenosine A and A receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Haiyan Li,Ji Aee Kim,Seong-Eun Jo,Huisu Lee,Kwan-Chang Kim,Shinkyu Choi,Suk Hyo Suh

Respiratory research 24:186 PubMed37438813

2023

Adenosine metabolized from extracellular ATP ameliorates organ injury by triggering AR signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Taha Kelestemur,Zoltán H Németh,Pal Pacher,Jennet Beesley,Simon C Robson,Holger K Eltzschig,György Haskó

Journal of cellular and molecular medicine 27:2150-2164 PubMed37278400

2023

Adenosine receptor A2b confers ovarian cancer survival and PARP inhibitor resistance through IL-6-STAT3 signalling.

Applications

Unspecified application

Species

Unspecified reactive species

Liqing Chi,Lin Huan,Chunyan Zhang,Hanming Wang,Jian Lu

Cancers 13: PubMed33925516

2021

Increased Extracellular Adenosine in Radiotherapy-Resistant Breast Cancer Cells Enhances Tumor Progression through A2AR-Akt-β-Catenin Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Hana Jin,Jong-Sil Lee,Dong-Chul Kim,Young-Shin Ko,Gyeong-Won Lee,Hye-Jung Kim

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Adenosine A2b Receptor/ADORA2B antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adenosine A2b Receptor/ADORA2B antibody (AB229671)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adenosine A2b Receptor/ADORA2B antibody (AB229671)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Primary Antibodies

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (8)

Product promise