Anti-Adenosine A2b Receptor/ADORA2B antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The Adenosine A2b Receptor (ADORA2B) is a member of the G-protein-coupled receptor family with alternative names including A2b Receptor and (A-2b). This receptor mediates its effects by binding adenosine a purine nucleoside found in various tissues. It has an approximate molecular weight of 36 kDa. ADORA2B is expressed in many tissues but shows larger expression in the colon bladder and lung. Its mechanical role involves activating adenylate cyclase through Gs protein coupling which increases intracellular cyclic AMP levels.

Biological function summary

The ADORA2B receptor plays a role in numerous physiological processes including immune response inflammation and response to hypoxia. It does not form part of a larger receptor complex; instead it acts independently. By modulating cAMP levels ADORA2B influences cellular responses affecting functions like smooth muscle relaxation and endothelial cell barrier function. This receptor is essential for regulating various biological rhythms and cellular stress responses.

Pathways

The ADORA2B receptor participates significantly in the adenosine signaling pathway and the hypoxia signaling pathway. In the adenosine signaling pathway ADORA2B interacts closely with proteins like adenylyl cyclase which are important for cAMP production. The receptor's activity can modulate the PKA (protein kinase A) pathway affecting downstream biological responses including the inflammatory and immune pathways.

Associated diseases and disorders

ADORA2B has links to conditions such as asthma and ischemic injury. In asthma the receptor's role in promoting inflammation is significant and it interacts with proteins like cytokines involved in inflammatory processes. In ischemic injury ADORA2B is implicated due to its involvement in the body's response to low oxygen levels. It interacts with hypoxia-inducible factors in this context affecting cellular survival and adaptation mechanisms.