AB203298

Anti-Adenosine A3 Receptor/A3AR antibody

Name: Anti-Adenosine A3 Receptor/A3AR antibody (ab203298) | Abcam
Brand: Abcam Limited
SKU: AB203298
Price: 535 USD
Availability: InStock
Rating: 5 (1 reviews)

(1 Review)

(9 Publications)

Rabbit Polyclonal Adenosine A3 Receptor/A3AR antibody. Suitable for WB and reacts with Mouse, Rat samples. Cited in 9 publications.

View Alternative Names

Adenosine receptor A3, ADORA3

1 Images

Supplier Data

Western blot - Anti-Adenosine A3 Receptor/A3AR antibody (AB203298)

All lanes:

Western blot - Anti-Adenosine A3 Receptor/A3AR antibody (ab203298) at 1/1000 dilution

Lane 1:

Mouse heart tissue lysate

Lane 2:

Mouse bone tissue lysate

Lane 3:

Rat heart tissue lysate

Secondary

All lanes:

Conjugated Secondary at 1/20000 dilution

Predicted band size: 36 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat, Mouse

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/1000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/1000", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Adenosine A3 Receptor (A3AR) also known as A3 adenosine receptor is a member of the G-protein-coupled receptor family. This receptor couples with Gi proteins to exert its effects. The receptor has a molecular weight of approximately 37 kDa. It is expressed in a variety of tissues including the heart liver lung and immune system cells. A3AR's activity involves binding with adenosine molecules which modulates different cellular responses.

Biological function summary

This receptor mediates several processes by interacting with specific ligands. A3AR is not a part of a larger receptor complex but plays a significant role in modulating inflammation and immune response. The receptor contributes to processes like cell proliferation apoptosis and protection against tissue damage. Its activation generally promotes anti-inflammatory effects making it a target for therapeutic research.

Pathways

Many important biological activities are associated with the adenosine signaling pathway. A3AR plays an essential role in the regulation of the inflammatory response and the apoptosis pathway. Through these pathways it interacts with various proteins such as adenylyl cyclase which responds to ligand binding affecting cAMP levels in cells. The receptor's influence on immune cell function links it to other adenosine receptor subtypes.

Several conditions exhibit A3AR involvement such as rheumatoid arthritis and cancer. A3AR's anti-inflammatory and pro-apoptotic characteristics make it a point of interest for modulating immune-related disorders. Research also explores its connection with proteins like NF-κB due to their role in inflammation and cancer progression. Overall A3AR remains an active target for therapeutic strategies aiming to control these diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Isoform 2. Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase (PubMed : 8234299).

See full target information ADORA3

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Publications (9)

Recent publications for all applications. Explore the full list and refine your search

Journal of orthopaedic translation 49:96-106 PubMed39430133

2024

CD73 alleviates osteoarthritis by maintaining anabolism and suppressing catabolism of chondrocytes extracellular matrix.

Applications

Unspecified application

Species

Unspecified reactive species

Hu Guo,Zhongyang Lv,Maochun Wang,Weitong Li,Ya Xie,Zizheng Liu,Fufei Chen,Ruiyang Jiang,Yuan Liu,Rui Wu,Jiawei Li,Ziying Sun,Guihua Tan,Dongquan Shi

International journal of molecular medicine 49: PubMed35039871

2022

2‑Cl‑IB‑MECA regulates the proliferative and drug resistance pathways, and facilitates chemosensitivity in pancreatic and liver cancer cell lines.

Applications

Unspecified application

Species

Unspecified reactive species

Jana Kotulova,Katerina Lonova,Agata Kubickova,Jana Vrbkova,Pavla Kourilova,Marian Hajduch,Petr Dzubak

Annals of translational medicine 9:526 PubMed33987224

2021

Adenosine A3 receptor activated in HO oxidative stress of primary open-angle glaucoma.

Applications

Unspecified application

Species

Unspecified reactive species

Ziyu Zhou,Zhaolin Gao,Weitao Yan,Yun Zhang,Jufang Huang,Kun Xiong

eLife 10: PubMed33416495

2021

Methotrexate attenuates vascular inflammation through an adenosine-microRNA-dependent pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Dafeng Yang,Stefan Haemmig,Haoyang Zhou,Daniel Pérez-Cremades,Xinghui Sun,Lei Chen,Jie Li,Jorge Haneo-Mejia,Tianlun Yang,Ivana Hollan,Mark W Feinberg

Aging cell 19:e13218 PubMed32790148

2020

Extracellular adenosine signaling reverses the age-driven decline in the ability of neutrophils to kill Streptococcus pneumoniae.

Applications

Unspecified application

Species

Unspecified reactive species

Manmeet Bhalla,Shaunna R Simmons,Alexsandra Abamonte,Sydney E Herring,Sara E Roggensack,Elsa N Bou Ghanem

Cellular microbiology 22:e13141 PubMed31709673

2019

A1 adenosine receptor signaling reduces Streptococcus pneumoniae adherence to pulmonary epithelial cells by targeting expression of platelet-activating factor receptor.

Applications

Unspecified application

Species

Unspecified reactive species

Manmeet Bhalla,Jun Hui Yeoh,Claire Lamneck,Sydney E Herring,Essi Y I Tchalla,Lauren R Heinzinger,John M Leong,Elsa N Bou Ghanem

Cell 179:864-879.e19 PubMed31675497

2019

Stress-Induced Metabolic Disorder in Peripheral CD4 T Cells Leads to Anxiety-like Behavior.

Applications

Unspecified application

Species

Unspecified reactive species

Ke-Qi Fan,Yi-Yuan Li,Hao-Li Wang,Xin-Tao Mao,Jin-Xin Guo,Fei Wang,Ling-Jie Huang,Yi-Ning Li,Xiang-Yu Ma,Zheng-Jun Gao,Wei Chen,Dan-Dan Qian,Wen-Jin Xue,Qian Cao,Lei Zhang,Li Shen,Long Zhang,Chao Tong,Jiang-Yan Zhong,Wei Lu,Ling Lu,Ke-Ming Ren,Guisheng Zhong,Yuan Wang,Mingliang Tang,Xin-Hua Feng,Ren-Jie Chai,Jin Jin

Cell death & disease 10:511 PubMed31263105

2019

Cardioprotective role of APIP in myocardial infarction through ADORA2B.

Applications

Unspecified application

Species

Unspecified reactive species

Bitna Lim,Kwangmin Jung,Youngdae Gwon,Jae Gyun Oh,Jae-Il Roh,Se-Hoon Hong,Changwon Kho,Woo-Jin Park,Han-Woong Lee,Jang-Whan Bae,Yong-Keun Jung

Contrast media & molecular imaging 2018:1269830 PubMed29666562

2018

Preclinical and Evaluation of [F]FE@SUPPY for Cancer PET Imaging: Limitations of a Xenograft Model for Colorectal Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

T Balber,J Singer,N Berroterán-Infante,M Dumanic,L Fetty,J Fazekas-Singer,C Vraka,L Nics,M Bergmann,K Pallitsch,H Spreitzer,W Wadsak,M Hacker,E Jensen-Jarolim,H Viernstein,M Mitterhauser

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Adenosine A3 Receptor/A3AR antibody

Western blot - Anti-Adenosine A3 Receptor/A3AR antibody (AB203298)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (9)

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