AB7428

Anti-Adenovirus antibody [B025 / AD51]

Name: Anti-Adenovirus antibody [B025 / AD51] (ab7428) | Abcam
Brand: Abcam Limited
SKU: AB7428
Price: 455 USD
Availability: InStock

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(9 Publications)

Anti-Adenovirus antibody [B025 / AD51] (ab7428) is a mouse monoclonal antibody detecting Adenovirus in IHC-P, IHC-Fr, ELISA. Suitable for Adenovirus.

- Trusted since 2001

View Alternative Names

Adenovirus

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

B025 / AD51

Isotype

IgG2a

Carrier free

Reacts with

Adenovirus

Applications

ELISA, IHC-P, IHC-Fr

applications

Specificity

This antibody recognises all Adenovirus serotypes; binding to the hexon polypeptide.No cross-reactions are known.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Adenovirus": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "1/1000", "IHCP-species-notes": "This product requires protein digestion pre-treatment of paraffin sections (e.g. trypsin or pronase) for 15 min prior to primary incubation", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" } } }

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Product details

What is this antibody validated in?
Anti-Adenovirus antibody [B025 / AD51] (ab7428) is a mouse monoclonal antibody and is validated for use in Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr), ELISA in Adenovirus samples.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Purification notes

Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant

Storage buffer

Preservative: 0.09% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Adenovirus also known by alternate names such as Adenoviren and Ad51 represents a group of medium-sized non-enveloped viruses with a double-stranded DNA genome. The adenovirus is approximately 90-100 nm in size and is notable for its icosahedral capsid structure. It primarily infects epithelial cells in the respiratory and gastrointestinal tracts but it can also affect other tissues. Its presence is recorded in diverse environments often acting as pathogens in humans and other animals.

Biological function summary

Adenoviruses function by hijacking the host cell's machinery to replicate their DNA and produce viral proteins. They do not form part of a larger complex; instead they independently orchestrate the synthesis of viral particles. Their proteins manipulate host cellular processes leading to cell lysis and viral release. Adenoviral proteins such as E1A and E1B play critical roles in their replication cycles and pathogenicity.

Pathways

Adenoviruses interact closely with pathways involved in cell cycle regulation and apoptosis. These viruses exploit cell cycle-associated proteins like p53 and Rb to immortalize host cells and evade apoptosis respectively. By bypassing normal regulatory checkpoints adenoviruses can ensure continuous replication and survival within the host.

Adenoviruses are commonly associated with conditions like acute respiratory diseases and gastroenteritis. They have a significant connection to the immune responses triggered in infected patients often involving proteins such as cytokines and chemokines. In some cases adenovirus-related infections can lead to severe outcomes in individuals with compromised immune systems demonstrating their impact on human health.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information Adenovirus

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Publications (9)

Recent publications for all applications. Explore the full list and refine your search

Respiratory research 25:425 PubMed39633448

2024

Human adenovirus type 7 (HAdV-7) infection induces pulmonary vascular endothelial injury through the activation of endothelial autophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Zhihe Chen,Zhongying Yang,Lifen Rao,Changgen Li,Na Zang,Enmei Liu

Haematologica 107:947-957 PubMed35045692

2022

Comparative analysis of ChAdOx1 nCoV-19 and Ad26.COV2.S SARS-CoV-2 vector vaccines.

Applications

Unspecified application

Species

Unspecified reactive species

Stephan Michalik,Florian Siegerist,Raghavendra Palankar,Kati Franzke,Maximilian Schindler,Alexander Reder,Ulrike Seifert,Clemens Cammann,Jan Wesche,Leif Steil,Christian Hentschker,Manuela Gesell-Salazar,Emil Reisinger,Martin Beer,Nicole Endlich,Andreas Greinacher,Uwe Völker

Blood 138:2256-2268 PubMed34587242

2021

Insights in ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopenia.

Applications

Unspecified application

Species

Unspecified reactive species

Andreas Greinacher,Kathleen Selleng,Raghavendra Palankar,Jan Wesche,Stefan Handtke,Martina Wolff,Konstanze Aurich,Michael Lalk,Karen Methling,Uwe Völker,Christian Hentschker,Stephan Michalik,Leif Steil,Alexander Reder,Linda Schönborn,Martin Beer,Kati Franzke,Andreas Büttner,Boris Fehse,Evi X Stavrou,Chandini Rangaswamy,Reiner K Mailer,Hanna Englert,Maike Frye,Thomas Thiele,Stefan Kochanek,Lea Krutzke,Florian Siegerist,Nicole Endlich,Theodore E Warkentin,Thomas Renné

The Journal of infectious diseases 223:1390-1399 PubMed32840612

2020

Clinical Features, Replication Competence, and Innate Immune Responses of Human Adenovirus Type 7 Infection.

Applications

Unspecified application

Species

Unspecified reactive species

Qigao Chen,Jun Liu,Weiwen Liang,Yi Chen,Min Dou,Zhongmin Liu,Yuan Chen,Zhongli Zheng,Bing Zhu,Yongping Lin

NPJ vaccines 5:39 PubMed32435513

2020

Evaluation of heterologous prime-boost vaccination strategies using chimpanzee adenovirus and modified vaccinia virus for TB subunit vaccination in rhesus macaques.

Applications

Unspecified application

Species

Unspecified reactive species

Michel P M Vierboom,Agnes L Chenine,Patricia A Darrah,Richard A W Vervenne,Charelle Boot,Sam O Hofman,Claudia C Sombroek,Karin Dijkman,Mohamed A Khayum,Marieke A Stammes,Krista G Haanstra,Chantal Hoffmann,Doris Schmitt,Nathalie Silvestre,Alexander G White,H Jacob Borish,Robert A Seder,Nadia Ouaked,Stephane Leung-Theung-Long,Geneviève Inchauspé,Ravi Anantha,Mary Limbach,Thomas G Evans,Danilo Casimiro,Maria Lempicki,Dominick J Laddy,Aurelio Bonavia,Frank A W Verreck

Journal of virology 91: PubMed27974569

2017

Human Adenovirus Type 37 Uses αβ and αβ Integrins for Infection of Human Corneal Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Rickard J Storm,B David Persson,Lars Nygård Skalman,Lars Frängsmyr,Mona Lindström,Greg Rankin,Richard Lundmark,Fatima Pedrosa Domellöf,Niklas Arnberg

Antiviral research 100:640-8 PubMed24149002

2013

Assessment of drug candidates for broad-spectrum antiviral therapy targeting cellular pyrimidine biosynthesis.

Applications

Unspecified application

Species

Unspecified reactive species

Manfred Marschall,Ina Niemann,Karin Kosulin,Anna Bootz,Sabrina Wagner,Thomas Dobner,Thomas Herz,Bernd Kramer,Johann Leban,Daniel Vitt,Thomas Stamminger,Corina Hutterer,Stefan Strobl

Journal of virology 81:13209-17 PubMed17686851

2007

Critical role for arginine methylation in adenovirus-infected cells.

Applications

Unspecified application

Species

Unspecified reactive species

Demetris C Iacovides,Clodagh C O'Shea,Juan Oses-Prieto,Alma Burlingame,Frank McCormick

Journal of clinical microbiology 37:3940-5 PubMed10565911

1999

Adenoviruses from human immunodeficiency virus-infected individuals, including two strains that represent new candidate serotypes Ad50 and Ad51 of species B1 and D, respectively.

Applications

Unspecified application

Species

Unspecified reactive species

J C De Jong,A G Wermenbol,M W Verweij-Uijterwaal,K W Slaterus,P Wertheim-Van Dillen,G J Van Doornum,S H Khoo,J C Hierholzer

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Adenovirus antibody [B025 / AD51]

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Specificity

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (9)

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