AB168748

Anti-ADH1C antibody

Name: Anti-ADH1C antibody (ab168748) | Abcam
Brand: Abcam Limited
SKU: AB168748
Price: 535 USD
Availability: InStock

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(2 Publications)

Rabbit Polyclonal ADH1C antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ADH1C.

View Alternative Names

ADH3, ADH1C, Alcohol dehydrogenase 1C, Alcohol dehydrogenase subunit gamma

4 Images

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Western blot - Anti-ADH1C antibody (AB168748)

All lanes:

Western blot - Anti-ADH1C antibody (ab168748) at 1 µg/mL

All lanes:

Raw 264.7 lysate at 50 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG (H+L), Peroxidase Conjugated secondary antibody at 1/7500 dilution

Predicted band size: 35 kDa,40 kDa

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Unknown

Western blot - Anti-ADH1C antibody (AB168748)

All lanes:

Western blot - Anti-ADH1C antibody (ab168748) at 1 µg/mL

All lanes:

Mouse liver lysate at 50 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG (H+L), Peroxidase Conjugated secondary antibody at 1/7500 dilution

Predicted band size: 40 kDa

false

Unknown

Western blot - Anti-ADH1C antibody (AB168748)

All lanes:

Western blot - Anti-ADH1C antibody (ab168748) at 1 µg/mL

All lanes:

Human liver lysate at 50 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG (H+L), Peroxidase Conjugated secondary antibody at 1/7500 dilution

Predicted band size: 40 kDa

false

Unknown

Western blot - Anti-ADH1C antibody (AB168748)

All lanes:

Western blot - Anti-ADH1C antibody (ab168748) at 1 µg/mL

Lane 1:

ADH1C transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Secondary

All lanes:

Goat Anti-Rabbit IgG (H+L), Peroxidase Conjugated secondary antibody at 1/7500 dilution

Predicted band size: 40 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

applications

Immunogen

Recombinant Full Length Protein corresponding to Human ADH1C.

P00326

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Baboon": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The ADH1C protein also known as alcohol dehydrogenase 1C plays an important role in the oxidation of alcohols to aldehydes and ketones. This enzyme features prominently in the metabolism of ethanol and other alcohols within the liver which is its primary expression site. ADH1C has a molecular mass of approximately 39 kDa and exists as a homodimer. This enzyme is part of a class of proteins responsible for breaking down alcohols utilizing NAD+ as a cofactor for their oxidizing reactions.

Biological function summary

Alcohol dehydrogenase 1C significantly influences the metabolism of alcohols in the liver. It contributes to the alcohol dehydrogenase complex which includes similar enzymes such as ADH1A and ADH1B. These enzymes work collaboratively to convert ethanol into acetaldehyde the first step in alcohol metabolism. ADH1C's activity affects the rate at which alcohol is processed impacting the accumulation of acetaldehyde which can be toxic in high concentrations.

Pathways

Alcohol dehydrogenase 1C plays a significant part in the ethanol metabolism pathway and the retinol metabolism pathway. In these pathways ADH1C interacts with other enzymes that facilitate the conversion of alcohols and retinoids into corresponding metabolites. ADH1C relates closely with aldehyde dehydrogenase proteins like ALDH2 which further processes acetaldehyde into acetate a less harmful substance. These pathways illustrate how ADH1C integrates into broader metabolic processes.

Alcohol dehydrogenase 1C shows relevance to alcohol-related liver disease and certain cancers. Variations in the ADH1C gene may influence an individual's susceptibility to liver damage from alcohol consumption. The connection between ADH1C acetaldehyde accumulation and disorders links it to ALDH2 whose deficiency enhances toxicity due to inefficient acetaldehyde breakdown. Understanding ADH1C's activity could allow for better risk assessments and therapeutic strategies aimed at alcohol-related health issues.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Alcohol dehydrogenase. Exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism.

See full target information ADH1C

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Food science & nutrition 12:5100-5110 PubMed39055233

2024

Restoring energy metabolism by NAD supplement prevents alcohol-induced liver injury and boosts liver regeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Yao Liu,Cheng Cheng,Han Gao,Xue-Jin Zhu,Xian He,Ming-Xi Zhou,Yuan Gao,Ya-Wen Lu,Xin-Hua Song,Xiao-He Xiao,Jia-Bo Wang,Chun-Jun Xu,Zhi-Tao Ma

International journal of molecular sciences 24: PubMed36835532

2023

MSX1 Regulates Goat Endometrial Function by Altering the Plasma Membrane Transformation of Endometrial Epithelium Cells during Early Pregnancy.

Applications

Unspecified application

Species

Unspecified reactive species

Beibei Zhang,Zongjie Wang,Kangkang Gao,Rao Fu,Huatao Chen,Pengfei Lin,Aihua Wang,Yaping Jin

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ADH1C antibody

Western blot - Anti-ADH1C antibody (AB168748)

Western blot - Anti-ADH1C antibody (AB168748)

Western blot - Anti-ADH1C antibody (AB168748)

Western blot - Anti-ADH1C antibody (AB168748)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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