AB25891

Anti-Adiponectin antibody

Name: Anti-Adiponectin antibody (ab25891) | Abcam
Brand: Abcam Limited
SKU: AB25891
Price: 605 USD
Availability: InStock

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(4 Publications)

Rabbit Polyclonal Adiponectin antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human ADIPOQ.

View Alternative Names

ACDC, ACRP30, APM1, GBP28, ADIPOQ, Adiponectin, 30 kDa adipocyte complement-related protein, Adipocyte complement-related 30 kDa protein, Adipose most abundant gene transcript 1 protein, Gelatin-binding protein, apM-1

1 Images

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Western blot - Anti-Adiponectin antibody (AB25891)

Lane 1:

Western blot - Anti-Adiponectin antibody (ab25891) at 0.5 µg/mL

Lane 2:

Western blot - Anti-Adiponectin antibody (ab25891) at 1 µg/mL

Lane 3:

Western blot - Anti-Adiponectin antibody (ab25891) at 2 µg/mL

All lanes:

HL60 cell lysate

Predicted band size: 26 kDa

Observed band size: 26 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Synthetic Peptide within Human ADIPOQ. The exact immunogen used to generate this antibody is proprietary information.

Q15848

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Adiponectin also known as ADIPOQ or adipocyte complement-related protein of 30 kDa (Acrp30) is a 30 kDa protein that plays a significant mechanical role in energy homeostasis. Adiponectin is secreted predominantly by adipose tissue and circulates in the blood. This protein forms various multimeric structures including low-molecular-weight medium-molecular-weight and high-molecular-weight forms each with distinct biological functions. Its expression in adipose tissue links it closely to metabolic processes and functions related to fat storage and energy balance.

Biological function summary

Adiponectin influences glucose regulation and fatty acid oxidation. It acts as a hormone with several metabolic roles including anti-diabetic anti-atherogenic and anti-inflammatory properties. Adiponectin participates in forming a complex with other proteins such as AdipoR1 and AdipoR2 which are receptors facilitating signal transduction. The interaction of adiponectin with its receptors leads to the induction of several lipid and glucose metabolism pathways important for maintaining cellular energy balance.

Pathways

Many regulatory cascades are influenced by adiponectin. This protein is integral to the AMPK signaling pathway and the PPAR signaling pathway. In the AMPK pathway adiponectin enhances insulin sensitivity and stimulates oxidation of fatty acids in muscle tissue. Through the PPAR pathway it influences lipid metabolism and storage. Adiponectin interacts with key proteins such as leptin and resistin coordinating various metabolic pathways to balance energy and glucose levels making it a critical factor in metabolic regulation.

Reduced levels of adiponectin associate with conditions like type 2 diabetes and cardiovascular disease. Lower circulating adiponectin concentrations correlate with obesity leading to increased insulin resistance and higher risk of type 2 diabetes. In cardiovascular disease this protein's role links to its anti-inflammatory properties and ability to decrease the proliferation of vascular smooth muscle cells. Adiponectin also interacts with proteins like cytokines that play a role in these conditions affecting the body’s inflammatory responses and metabolic processes highlighting its importance in health and disease management.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.

See full target information ADIPOQ

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Archives of medical science : AMS 17:323-336 PubMed33747267

2021

Adipokine signatures of subcutaneous and visceral abdominal fat in normal-weight and obese women with different metabolic profiles.

Applications

Unspecified application

Species

Unspecified reactive species

Aleksandra Korac,Biljana Srdic-Galic,Andjelika Kalezic,Ana Stancic,Vesna Otasevic,Bato Korac,Aleksandra Jankovic

Molecular medicine reports 16:6170-6177 PubMed28849047

2017

Conditioned medium from tonsil‑derived mesenchymal stem cells promotes adiponectin production.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Hee Kim,Kyung-Ah Cho,Minhwa Park,Julie A Webster,So-Youn Woo,Kyung-Ha Ryu

Diabetes 57:2321-31 PubMed18599527

2008

Metabolically favorable remodeling of human adipose tissue by human adenovirus type 36.

Applications

Species

Human

Pamela M Rogers,Nazar Mashtalir,Miloni A Rathod,Olga Dubuisson,Zhong Wang,Kumar Dasuri,Scott Babin,Alok Gupta,Nathan Markward,William T Cefalu,Nikhil V Dhurandhar

The American journal of pathology 172:1069-80 PubMed18310505

2008

A developmental model of sarcomagenesis defines a differentiation-based classification for liposarcomas.

Applications

Species

Human

Igor Matushansky,Eva Hernando,Nicholas D Socci,Tulio Matos,Joslyn Mills,Mark A Edgar,Gary K Schwartz,Samuel Singer,Carlos Cordon-Cardo,Robert G Maki

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Adiponectin antibody

Western blot - Anti-Adiponectin antibody (AB25891)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

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