AB223752

Anti-Adiponectin Receptor 2/ADIPOR2 antibody

Name: Anti-Adiponectin Receptor 2/ADIPOR2 antibody (ab223752) | Abcam
Brand: Abcam Limited
SKU: AB223752
Price: 535 USD
Availability: InStock

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(2 Publications)

Rabbit Polyclonal Adiponectin Receptor 2/ADIPOR2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ADIPOR2 aa 1-100.

View Alternative Names

PAQR2, ADIPOR2, Adiponectin receptor protein 2, Progestin and adipoQ receptor family member 2, Progestin and adipoQ receptor family member II

4 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (AB223752)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (AB223752)

Paraffin-embedded human skeletal muscle tissue stained for Adiponectin Receptor 2/ADIPOR2 using ab223752 at 1/20 dilution in immunohistochemical analysis.

Moderate cytoplasmic positivity in myocytes.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (AB223752)

Paraffin-embedded human heart muscle tissue stained for Adiponectin Receptor 2/ADIPOR2 using ab223752 at 1/20 dilution in immunohistochemical analysis.

Moderate cytoplasmic positivity in cardiomyocytes.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (AB223752)

Paraffin-embedded human placenta tissue stained for Adiponectin Receptor 2/ADIPOR2 using ab223752 at 1/20 dilution in immunohistochemical analysis.

Strong cytoplasmic positivity in decidual cells.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (AB223752)

Paraffin-embedded human small intestine tissue stained for Adiponectin Receptor 2/ADIPOR2 using ab223752 at 1/20 dilution in immunohistochemical analysis.

Moderate cytoplasmic positivity in glandular cells.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ADIPOR2 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q86V24

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Adiponectin Receptor 2 also known as ADIPOR2 or the adiponectin receptor is an integral membrane protein responsible for mediating the effects of adiponectin a hormone involved in regulating glucose and fatty acid metabolism. ADIPOR2 has a mass of about 39 kDa. It is predominantly expressed in skeletal muscle and liver tissues. The receptor plays a critical role in energy homeostasis and glucose regulation by binding to adiponectin which facilitates the activation of downstream signaling pathways.

Biological function summary

ADIPOR2 influences energy balance and lipid metabolism. It is not part of a larger protein complex but functions in concert with another receptor Adiponectin Receptor 1 (ADIPOR1). The action of ADIPOR2 helps to enhance insulin sensitivity and fatty acid oxidation. The receptor also contributes to the regulation of metabolic rate and glucose uptake in the liver and muscle tissues supporting overall metabolic health.

Pathways

ADIPOR2 connects to important metabolic routes such as the AMP-activated protein kinase (AMPK) pathway and the peroxisome proliferator-activated receptor alpha (PPARα) pathway. These pathways are important for cellular energy management and metabolic adaptation. ADIPOR2 cooperates with proteins like AMPK and PPARα to regulate lipid and glucose metabolism contributing to increased insulin sensitivity and efficient energy use in cells.

ADIPOR2 has links to conditions such as type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). The receptor’s role in enhancing insulin sensitivity and promoting fatty acid oxidation makes it a significant target for understanding and potentially treating these metabolic disorders. Additionally its connection with proteins like AMPK suggests that manipulating ADIPOR2 activity could offer therapeutic benefits for managing insulin resistance and fatty liver-associated diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed : 12802337, PubMed : 25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).

See full target information ADIPOR2

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cancer medicine 14:e71007 PubMed40642843

2025

Exploring the Relationship Between Adipocytokines and Endometrial Cancer: Identifying Correlations With Clinico-Pathological Prognostic Factors.

Applications

Unspecified application

Species

Unspecified reactive species

Irene Ray,Carla S Möller-Levet,Agnieszka Michael,Simon Butler-Manuel,Jayanta Chatterjee,Anil Tailor,Ben Haagsma,Izhar Bagwan,Lisiane B Meira,Patricia E Ellis

Nature : PubMed38057666

2023

A human embryonic limb cell atlas resolved in space and time.

Applications

Unspecified application

Species

Unspecified reactive species

Bao Zhang,Peng He,John E G Lawrence,Shuaiyu Wang,Elizabeth Tuck,Brian A Williams,Kenny Roberts,Vitalii Kleshchevnikov,Lira Mamanova,Liam Bolt,Krzysztof Polanski,Tong Li,Rasa Elmentaite,Eirini S Fasouli,Martin Prete,Xiaoling He,Nadav Yayon,Yixi Fu,Hao Yang,Chen Liang,Hui Zhang,Raphael Blain,Alain Chedotal,David R FitzPatrick,Helen Firth,Andrew Dean,Omer Ali Bayraktar,John C Marioni,Roger A Barker,Mekayla A Storer,Barbara J Wold,Hongbo Zhang,Sarah A Teichmann

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Adiponectin Receptor 2/ADIPOR2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (AB223752)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (AB223752)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (AB223752)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (AB223752)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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