AB231051

Anti-Adiponectin Receptor 2/ADIPOR2 antibody

Name: Anti-Adiponectin Receptor 2/ADIPOR2 antibody (ab231051) | Abcam
Brand: Abcam Limited
SKU: AB231051
Price: 525 USD
Availability: InStock

Be the first to review this product! Submit a review

(1 Publication)

Rabbit Polyclonal Adipor2 antibody. Suitable for WB, IHC-P and reacts with Rat samples. Cited in 1 publication.

View Alternative Names

ACDCR2, ADR2_HUMAN, Adiponectin receptor protein 2, Progestin and adipoQ receptor family member II

8 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (AB231051)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (AB231051)

Paraffin-embedded rat heart tissue stained for Adiponectin Receptor 2/ADIPOR2 using ab231051 at 20 μg/ml in immunohistochemical analysis, followed by DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (AB231051)

Paraffin-embedded rat stomach tissue stained for Adiponectin Receptor 2/ADIPOR2 using ab231051 at 20 μg/ml in immunohistochemical analysis, followed by DAB staining.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (AB231051)

Paraffin-embedded rat kidney tissue stained for Adiponectin Receptor 2/ADIPOR2 using ab231051 at 20 μg/ml in immunohistochemical analysis, followed by DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (AB231051)

Paraffin-embedded rat testis tissue stained for Adiponectin Receptor 2/ADIPOR2 using ab231051 at 20 μg/ml in immunohistochemical analysis, followed by DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (AB231051)

Paraffin-embedded rat liver tissue stained for Adiponectin Receptor 2/ADIPOR2 using ab231051 at 20 μg/ml in immunohistochemical analysis, followed by DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (AB231051)

Paraffin-embedded rat skeletal muscle tissue stained for Adiponectin Receptor 2/ADIPOR2 using ab231051 at 20 μg/ml in immunohistochemical analysis, followed by DAB staining.

Supplier Data

Western blot - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (AB231051)

All lanes:

Western blot - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (ab231051) at 1 µg/mL

Lane 1:

Rat serum

Lane 2:

Rat uterus lysate

Secondary

All lanes:

HRP-Linked Guinea pig Anti-Rabbit antibody at 1/2000 dilution

Predicted band size: 44 kDa

false

Supplier Data

Western blot - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (AB231051)

All lanes:

Western blot - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (ab231051) at 2 µg/mL

All lanes:

Recombinant rat Adiponectin Receptor 2/ADIPOR2 protein

Predicted band size: 164 kDa,22 kDa,23 kDa,37 kDa,44 kDa,57 kDa

Observed band size: 22 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat

Applications

IHC-P, WB

applications

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

ab231051 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Adiponectin Receptor 2 also known as ADIPOR2 or the adiponectin receptor is an integral membrane protein responsible for mediating the effects of adiponectin a hormone involved in regulating glucose and fatty acid metabolism. ADIPOR2 has a mass of about 39 kDa. It is predominantly expressed in skeletal muscle and liver tissues. The receptor plays a critical role in energy homeostasis and glucose regulation by binding to adiponectin which facilitates the activation of downstream signaling pathways.

Biological function summary

ADIPOR2 influences energy balance and lipid metabolism. It is not part of a larger protein complex but functions in concert with another receptor Adiponectin Receptor 1 (ADIPOR1). The action of ADIPOR2 helps to enhance insulin sensitivity and fatty acid oxidation. The receptor also contributes to the regulation of metabolic rate and glucose uptake in the liver and muscle tissues supporting overall metabolic health.

Pathways

ADIPOR2 connects to important metabolic routes such as the AMP-activated protein kinase (AMPK) pathway and the peroxisome proliferator-activated receptor alpha (PPARα) pathway. These pathways are important for cellular energy management and metabolic adaptation. ADIPOR2 cooperates with proteins like AMPK and PPARα to regulate lipid and glucose metabolism contributing to increased insulin sensitivity and efficient energy use in cells.

ADIPOR2 has links to conditions such as type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). The receptor’s role in enhancing insulin sensitivity and promoting fatty acid oxidation makes it a significant target for understanding and potentially treating these metabolic disorders. Additionally its connection with proteins like AMPK suggests that manipulating ADIPOR2 activity could offer therapeutic benefits for managing insulin resistance and fatty liver-associated diseases.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

See full target information Adipor2

style

left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 13:873382 PubMed35720361

2022

Adiponectin Ameliorates GMH-Induced Brain Injury by Regulating Microglia M1/M2 Polarization AdipoR1/APPL1/AMPK/PPARγ Signaling Pathway in Neonatal Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Ningbo Xu,Xifeng Li,Jun Weng,Chunhua Wei,Zhenyan He,Desislava Met Doycheva,Cameron Lenahan,Wenhui Tang,Jian Zhou,Yanchao Liu,Qiang Xu,Yahong Liu,Xuying He,Jiping Tang,John H Zhang,Chuanzhi Duan

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Adiponectin Receptor 2/ADIPOR2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (AB231051)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (AB231051)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (AB231051)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (AB231051)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (AB231051)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (AB231051)

Western blot - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (AB231051)

Western blot - Anti-Adiponectin Receptor 2/ADIPOR2 antibody (AB231051)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Alternative Products

Primary Antibodies

Complementary Products

Primary Antibodies

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Product promise