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AB203584

Anti-ADM2/AM2 antibody

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(1 Publication)

Rabbit Polyclonal ADM2/AM2 antibody. Suitable for IHC-P and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ADM2 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

AM2, ADM2, Protein ADM2, Intermedin

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADM2/AM2 antibody (AB203584)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADM2/AM2 antibody (AB203584)

Immunohistochemical analysis of formalin-fixed, paraffin embedded Human gastric cancer tissue labeling ADM2/AM2 with ab203584 at 1/100 dilution, followed by conjugation to the secondary antibody and DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADM2/AM2 antibody (AB203584)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADM2/AM2 antibody (AB203584)

Immunohistochemical analysis of formalin-fixed, paraffin embedded rat small intestine tissue labeling ADM2/AM2 with ab203584 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human ADM2 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q7Z4H4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p>1/50 - 1/200 using a fluorescent secondary antibody.</p>" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p>1/50 - 1/200 using a fluorescent secondary antibody.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ADM2 also known as adrenomedullin 2 or intermedin is a peptide with various roles in the body. This peptide consists of 47 amino acids and usually has a molecular mass of about 5.1 kDa. You can find ADM2 expression in several tissues including the heart kidney and brain where it carries out several physiological functions. In these tissues ADM2 acts through binding to the calcitonin receptor-like receptor (CLR) in the presence of receptor activity-modifying proteins (RAMPs).
Biological function summary

The function of ADM2 centers on its role as a vasoactive peptide. ADM2 possesses vasodilatory effects helping regulate blood pressure and fluid balance. It forms part of a receptor complex that includes CLR and specific RAMPs allowing it to exert its effects efficiently. This interaction modulates vascular tone and cardiac output contributing to overall cardiovascular health.

Pathways

ADM2 is active in the G protein-coupled receptor signaling pathway. Its effects are closely linked to the cyclic AMP (cAMP) signaling pathway an essential pathway for numerous physiological responses. ADM2 interacts with proteins such as CLR and RAMPs facilitating cAMP production and eliciting downstream effects that include vasodilation and other protective cardiovascular effects.

Researchers have noted the involvement of ADM2 in cardiovascular diseases and hypertension. Its regulatory effect on blood vessels links it closely with conditions such as hypertension where increased ADM2 activity may represent a protective mechanism. ADM2's relationship with proteins like CLR and RAMPs suggests therapeutic potential for managing conditions involving vascular dysfunction.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Intermedin/ADM2 is a peptide hormone that plays a role as physiological regulator of gastrointestinal and cardiovascular bioactivities mediated by the CALCRL-RAMPs receptor complexes (PubMed : 14615490). Activates the cAMP-dependent pathway through interaction with CALCRL-RAMP3 receptor complex (PubMed : 14615490).
See full target information ADM2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Ophthalmology and therapy 10:63-74 PubMed33188486

2020

Expression of LIGHT/TNFSF14 and Its Receptors, HVEM and LTβR, Correlates with the Severity of Fibrosis in Lacrimal Sacs from Patients with Lacrimal Duct Obstruction.

Applications

Unspecified application

Species

Unspecified reactive species

Pawel Bielecki,Ewa Gindzienska-Sieskiewicz,Joanna Reszeć,Bartosz Piszczatowski,Marek Rogowski,Otylia Kowal-Bielecka,Krzysztof Kowal,Andrzej Sieskiewicz
View all publications
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Product promise

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