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AB231950

Anti-ADNP antibody

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(2 Publications)

Rabbit Polyclonal ADNP antibody. Suitable for WB and reacts with Human, Recombinant full length protein - Human, Pig samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ADNP aa 500-800.

View Alternative Names

ADNP1, KIAA0784, ADNP, Activity-dependent neuroprotector homeobox protein, Activity-dependent neuroprotective protein

2 Images
Western blot - Anti-ADNP antibody (AB231950)
  • WB

Supplier Data

Western blot - Anti-ADNP antibody (AB231950)

All lanes:

Western blot - Anti-ADNP antibody (ab231950) at 1 µg/mL

Lane 1:

Human lung tissue lysate

Lane 2:

HeLa (human epithelial cell line from cervix adenocarcinoma) cell lysate

Lane 3:

Pig heart tissue lysate

Secondary

All lanes:

HRP-Linked Guinea pig anti-rabbit at 1/2000 dilution

Predicted band size: 124 kDa

false

Western blot - Anti-ADNP antibody (AB231950)
  • WB

Supplier Data

Western blot - Anti-ADNP antibody (AB231950)

All lanes:

Western blot - Anti-ADNP antibody (ab231950) at 1 µg/mL

All lanes:

Recombinant human ADNP protein

Predicted band size: 124 kDa,29 kDa,464 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, Pig

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human ADNP aa 500-800. The exact immunogen used to generate this antibody is proprietary information.

Q9H2P0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>" }, "Recombinant full length protein - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The ADNP protein also known as Activity-dependent neuroprotector homeobox is a multifunctional protein with a mass of about 123 kDa. ADNP is highly expressed in the brain but also present in other tissues including heart and kidney. It regulates neural development and synaptic plasticity by interacting with chromatin and participating in transcriptional activities. The protein plays a role in cell cycle regulation and is involved in neuroprotection against multiple insults.
Biological function summary

ADNP plays critical roles in the development of the nervous system and maintenance of neuronal function. As part of a chromatin remodeling complex known as SWI/SNF it modulates the expression of genes necessary for neurogenesis and neuronal survival. ADNP affects microtubule dynamics which are important for neuron structure and transport by regulating activity of associated proteins. These functions make ADNP influential in maintaining a healthy nervous system and protecting against neurodegenerative processes.

Pathways

ADNP is necessary for proper functioning in neuroprotective pathways and the regulation of gene expression pathways. It closely interacts with the proteins REST and HDAC2 in the regulation of transcription important for neuronal cell survival. The involvement in Wnt signaling pathway an important regulator of cell proliferation and differentiation highlights its importance in neural development and plasticity. ADNP also affects the activity of MAPK/ERK pathway which links it to the control of cell proliferation and survival.

ADNP mutations or dysregulations have been connected to neurodevelopmental disorders such as Helsmoortel-Van der Aa syndrome and Alzheimer's disease. In relation to Helsmoortel-Van der Aa syndrome disruptions in ADNP lead to intellectual disability and developmental delays due to impaired neural growth. In Alzheimer's disease changes in ADNP expression affect the stability and function of tau a protein involved in neurofibrillary tangles. These interactions underline ADNP's significance in neuropsychiatric disorders and potential as a therapeutic target.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity).
See full target information ADNP
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

MedComm 6:e70311 PubMed40761479

2025

Nanoparticle-Delivered siRNA Targeting NSUN4 Relieves Systemic Lupus Erythematosus through Declining Mitophagy-Mediated CD8+T Cell Exhaustion.

Applications

Unspecified application

Species

Unspecified reactive species

Bincheng Ren,Kaini He,Ning Wei,Shanshan Liu,Xiaoguang Cui,Xin Yang,Xiaojing Cheng,Tian Tian,Ru Gu,Xueyi Li

eLife 12: PubMed37934570

2023

ZMYM2 controls human transposable element transcription through distinct co-regulatory complexes.

Applications

Unspecified application

Species

Unspecified reactive species

Danielle J Owen,Elisa Aguilar-Martinez,Zongling Ji,Yaoyong Li,Andrew D Sharrocks
View all publications
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