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AB229252

Anti-ADPRHL1 antibody

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(2 Publications)

Rabbit Polyclonal ADPRHL1 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ADPRHL1.

View Alternative Names

ARH2, ADPRHL1, Inactive ADP-ribosyltransferase ARH2, ADP-ribosylhydrolase-like protein 1, [Protein ADP-ribosylarginine] hydrolase-like protein 1

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-ADPRHL1 antibody (AB229252)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-ADPRHL1 antibody (AB229252)

HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for ADPRHL1 (green) using ab229252 (1/500 dilution) in ICC/IF. Cells were fixed in 4% paraformaldehyde at RT for 15 minutes.

Nuclear counterstain : Hoechst 33342 (blue).

Western blot - Anti-ADPRHL1 antibody (AB229252)
  • WB

Supplier Data

Western blot - Anti-ADPRHL1 antibody (AB229252)

12% SDS-PAGE

All lanes:

Western blot - Anti-ADPRHL1 antibody (ab229252) at 1/500 dilution

All lanes:

Mouse heart tissue extracts at 50 µg

Predicted band size: 40 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human ADPRHL1. The exact immunogen used to generate this antibody is proprietary information.

Q8NDY3

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Complementary Products

Proteins & Peptides

AB127287

Recombinant Human ADPRHL1 protein

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Primary Antibodies

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ADPRHL1 also known as ADP-ribosylhydrolase like protein 1 is an enzyme involved in the hydrolysis of ADP-ribose protein modifications. This protein belongs to the ADP-ribosylhydrolase family and is thought to weigh around 34 kDa. ADPRHL1 expression is notable in cardiac tissues and to some extent in skeletal muscles indicating a role in muscle function. The expression pattern points toward a specific function related to muscle physiology.
Biological function summary

ADPRHL1 plays an essential role in regulating ADP-ribosylation a reversible post-translational modification that influences several cellular processes including stress responses and DNA repair. It acts by removing ADP-ribose groups from arginine or cysteine residues in target proteins playing a regulatory role in cellular homeostasis and signaling processes. While ADPRHL1 does not appear to be part of a large multi-protein complex its functions are vital for maintaining normal proteomic balance in cells especially in tissues with high metabolic demands like the heart.

Pathways

Several cellular processes involve ADPRHL1 due to its role in ADP-ribosylation. This protein takes part in DNA repair pathways and some elements of cellular stress response. It interrelates with enzymes such as PARP1 in the poly-ADP-ribosylation pathway contributing to controlling cellular stress and maintaining genomic integrity. By managing these pathways ADPRHL1 collaborations maintain homeostasis and protect against cellular damage.

Researchers have linked ADPRHL1 to cardiac hypertrophy and certain muscular dystrophies pointing to its critical importance in heart and muscle health. The protein's malfunction or irregular expression might connect to pathologies involving these conditions. Some studies suggest interactions with titin a protein contributing to muscle assembly and cardiac stability hinting at the impact ADPRHL1 may have on muscle-related diseases. These connections make ADPRHL1 a potential target for therapeutic interventions in muscle and heart disease research.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Required for myofibril assembly and outgrowth of the cardiac chambers in the developing heart (By similarity). Appears to be catalytically inactive, showing no activity against O-acetyl-ADP-ribose (By similarity).
See full target information ADPRHL1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Bioactive materials 53:737-753 PubMed40801020

2025

Inhibition of ARH2 by pH/ROS-responsive nanosystem for improved lung adenocarcinoma immunochemotherapy.

Applications

Unspecified application

Species

Unspecified reactive species

Rui Cai,Meng Wang,Mengting Pan,Zhiwu Zhang,Qiang Jia,Longbao Feng,Zhongjian Yu,Lu Liu,Tongyu Zhu,Silin Cai,Han Tian,Jiangyu Zhang,Rui Guo,Yanfang Zheng

PLoS biology 19:e3001352 PubMed34491982

2021

The antiviral state has shaped the CpG composition of the vertebrate interferome to avoid self-targeting.

Applications

Unspecified application

Species

Unspecified reactive species

Andrew E Shaw,Suzannah J Rihn,Nardus Mollentze,Arthur Wickenhagen,Douglas G Stewart,Richard J Orton,Srikeerthana Kuchi,Siddharth Bakshi,Mila Rodriguez Collados,Matthew L Turnbull,Joseph Busby,Quan Gu,Katherine Smollett,Connor G G Bamford,Elena Sugrue,Paul C D Johnson,Ana Filipe Da Silva,Alfredo Castello,Daniel G Streicker,David L Robertson,Massimo Palmarini,Sam J Wilson
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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