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AB317380

Anti-AdSS 2 antibody [S05-8F8]

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Rabbit Monoclonal AdSS 2 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Immunogen corresponding to Recombinant Fragment Protein within Human ADSS2.

View Alternative Names

ADSS, ADSS2, Adenylosuccinate synthetase isozyme 2, AMPSase 2, AdSS 2, IMP--aspartate ligase 2, L-type adenylosuccinate synthetase

1 Images
Western blot - Anti-AdSS 2 Antibody [S05-8F8] (AB317380)
  • WB

Supplier Data

Western blot - Anti-AdSS 2 Antibody [S05-8F8] (AB317380)

All lanes:

Western blot - Anti-AdSS 2 Antibody [S05-8F8] (ab317380) at 1/1000 dilution

Lane 1:

K562 cell lysate

Lane 2:

Rat brain lysate

Lane 3:

C6 cell lysate

Lane 4:

NIH/3T3 cell lysate

Lane 5:

HeLa cell lysate

Predicted band size: 50 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

S05-8F8

Isotype

IgG

Carrier free

No

Reacts with

Human, Mouse, Rat

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human ADSS2.

P30520

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Storage buffer
pH: 7.4 Preservative: 0.01% Sodium azide Constituents: 55.08% Water, 40% Glycerol (glycerin, glycerine), 0.98% Tris glycine, 0.88% Sodium chloride, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AdSS 2 also known as Adenylate Succinate Synthase 2 is an enzyme that functions in the cellular ATP generation process. It catalyzes an important step in the purine nucleotide cycle specifically the conversion of inosine monophosphate (IMP) to adenylosuccinate. This enzyme has an approximate molecular weight of 55 kDa. AdSS 2 is widely expressed in tissues with high energy demands such as liver muscle and brain where it plays a major role in maintaining cellular energy balance.
Biological function summary

AdSS 2 is important for the synthesis of AMP from IMP acting as a part of the purine biosynthesis pathway. It does not work alone; it associates with other enzymes involved in the nucleotide metabolism complex ensuring efficiency of ATP production. This activity supports various cellular functions that require rapid energy turnover reflecting its necessity in tissues with intense metabolic activity.

Pathways

This enzyme integrates into the broader purine metabolism and energy homeostasis pathways. It connects with the enzyme fumarase in a pathway that regulates the TCA cycle's connection to nucleotide metabolism. Furthermore its interaction with proteins like adenylosuccinate lyase shows its involvement in the cascading steps of purine synthesis helping maintain a balance between energy supply and demand.

AdSS 2 has relevant implications in metabolic conditions like gout and certain types of myopathies. Mutations in this enzyme can disrupt purine metabolism leading to excessive accumulation of uric acid a hallmark of gout. Similarly impaired AdSS 2 function links to muscle disorders where energy metabolism is compromised. Proteins such as adenylosuccinate lyase and fumarase may be co-involved in these metabolic disorders highlighting the interconnected nature of metabolic function and disease.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
See full target information ADSS2

Additional targets

Adss2,Adss2
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Product promise

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