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AB254973

Anti-AEBP1 antibody

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(4 Publications)

Rabbit Polyclonal AEBP1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human AEBP1 aa 250-400.

View Alternative Names

ACLP, AEBP1, Adipocyte enhancer-binding protein 1, AE-binding protein 1, Aortic carboxypeptidase-like protein

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AEBP1 antibody (AB254973)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AEBP1 antibody (AB254973)

Paraffin-embedded human liver tissue stained for AEBP1 using ab254973 at 1/200 dilution in immunohistochemical analysis. Low expression as expected.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AEBP1 antibody (AB254973)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AEBP1 antibody (AB254973)

Paraffin-embedded human seminal vesicle tissue stained for AEBP1 using ab254973 at 1/200 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human AEBP1 aa 250-400. The exact immunogen used to generate this antibody is proprietary information.

Q8IUX7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AEBP1 also known as Adipocyte Enhancer-Binding Protein 1 functions as a transcriptional repressor in the regulation of gene expression. AEBP1 has a molecular mass of approximately 160 kDa. This protein is expressed mainly in adipose tissues but researchers also find it in the brain lung and skeletal muscle suggesting a broader role in different tissues. AEBP1 contains a proline-rich domain and a DNA-binding domain which facilitate its function in the nucleus.
Biological function summary

AEBP1 influences functions associated with cellular proliferation and differentiation. The protein interacts with nuclear factor-kB (NF-kB) playing a significant role in immune response modulation. AEBP1 does not typically appear as part of a larger complex but instead exerts its effects through direct binding to target DNA sequences. This binding alters gene expression patterns impacting processes like inflammation and lipid metabolism.

Pathways

AEBP1 shows involvement in the NF-kB signaling pathway and the PI3K/AKT pathway. These pathways play critical roles in cell survival proliferation and immune response. AEBP1 modulates these signaling cascades through its direct interaction with NF-kB influencing downstream gene expression. Its activity shows overlap with proteins like AKT and IKK linking it to broader cellular processes and regulatory networks.

AEBP1 has associations with obesity and cardiovascular diseases. Its regulation of adipogenesis and lipid metabolism contributes to the development of obesity. This protein further impacts cardiovascular health through its modulation of inflammation an important factor in cardiovascular disease development. AEBP1 also shares connections with proteins like PPARγ and leptin which are pivotal in metabolic disorder progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Isoform 1. As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix.. Isoform 2. May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.
See full target information AEBP1
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:8171 PubMed40890191

2025

AEBP1 drives fibroblast-mediated T cell dysfunction in tumors.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoyu Wang,Jie Li,Daqiang Song,Yushen Wu,Jiazhou Liu,Ziying Yi,Jiazheng Sun,Jiefeng Huang,Linling Wu,Xiang Zhang,Jingyuan Wan,Li Zhang,Chong Li,Fan Li,Yuxian Wei,Yong Zhu,Huimin Du,Guosheng Ren,Hongzhong Li

CytoJournal 22:5 PubMed39958879

2025

Relationship between transmembrane emp24 domain containing 2 expression and tumor stem cell characteristics in oral cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yanhui Wu,Shunchu Zhang,Guimei Zou

Arthritis research & therapy 27:28 PubMed39930483

2025

Proteomic profiling of human plasma and intervertebral disc tissue reveals matrisomal, but not plasma, biomarkers of disc degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Christabel Thembela Dube,Hamish T J Gilbert,Niamh Rabbitte,Pauline Baird,Sonal Patel,Jeremy A Herrera,Ivona Baricevic-Jones,Richard D Unwin,Danny Chan,Kanna Gnanalingham,Judith A Hoyland,Stephen M Richardson

Neoplasia (New York, N.Y.) 49:100972 PubMed38237535

2024

AEBP1 promotes papillary thyroid cancer progression by activating BMP4 signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Gaoda Ju,Tao Xing,Miaomiao Xu,Xin Zhang,Yuqing Sun,Zhuanzhuan Mu,Di Sun,Sen Miao,Li Li,Jun Liang,Yansong Lin
View all publications
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