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AB9096

Anti-Aequorin antibody

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(7 Publications)

Rabbit Polyclonal Aequorin antibody. Suitable for ELISA, WB and reacts with Aequorea victoria samples. Cited in 7 publications.

View Alternative Names

Aequorin 1, Aequorin 2

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Aequorea victoria

Applications

ELISA, WB

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Aequorea victoria": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Aequorin is a calcium-binding protein originally extracted from the jellyfish Aequorea victoria. It is known for its luminescent properties and serves as a biochemical tool in calcium signaling studies. The molecular mass of aequorin is approximately 22 kDa. Although first identified in marine organisms aequorin is not naturally expressed in humans or other terrestrial species. Researchers often use genetically engineered cells to study aequorin's function in different biological settings.
Biological function summary

Aequorin detects intracellular calcium levels by emitting light when it binds to calcium ions. It is not part of a larger protein complex but acts independently. Scientists often use aequorin for real-time measurement of calcium in various organisms providing insights into calcium-mediated pathways. Its capacity to produce measurable luminescence upon calcium binding makes it a valuable tool in research.

Pathways

Calcium signaling significantly involves aequorin. In particular aequorin allows precise measurement of calcium flux in pathways like the excitation-contraction coupling in muscle cells and nerve impulse propagation. These pathways often associate with proteins such as calmodulin which also binds calcium and modulates cellular activities. Aequorin enhances the understanding of these pathways by providing real-time data on calcium levels.

Calcium dysregulation involving aequorin insights relates to cardiac arrhythmias and neurodegenerative disorders. Aberrant calcium signaling can lead to irregular heartbeats where proteins like calmodulin and troponin play roles. Aequorin-based studies help to better understand calcium's role in these diseases assisting in exploring potential interventions targeting the signaling mechanisms involved.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Aequorin
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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

The Journal of biological chemistry 299:104647 PubMed36965615

2023

The Ycx1 protein encoded by the yeast YDL206W gene plays a role in calcium and calcineurin signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Grace M Lee,Fangli Weng,Juliana Cranley,Abhinav Rajasekhar,Matthew Stoeckel,Thomas Kane,Renata Tisi,Yuqi Wang

Nature 585:569-573 PubMed32846426

2020

The calcium-permeable channel OSCA1.3 regulates plant stomatal immunity.

Applications

Unspecified application

Species

Unspecified reactive species

Kathrin Thor,Shushu Jiang,Erwan Michard,Jeoffrey George,Sönke Scherzer,Shouguang Huang,Julian Dindas,Paul Derbyshire,Nuno Leitão,Thomas A DeFalco,Philipp Köster,Kerri Hunter,Sachie Kimura,Julien Gronnier,Lena Stransfeld,Yasuhiro Kadota,Christoph A Bücherl,Myriam Charpentier,Michael Wrzaczek,Daniel MacLean,Giles E D Oldroyd,Frank L H Menke,M Rob G Roelfsema,Rainer Hedrich,José Feijó,Cyril Zipfel

Science China. Life sciences 59:811-24 PubMed27430888

2016

Expression and reconstitution of the bioluminescent Ca(2+) reporter aequorin in human embryonic stem cells, and exploration of the presence of functional IP3 and ryanodine receptors during the early stages of their differentiation into cardiomyocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Harvey Y S Chan,Man Chun Cheung,Yi Gao,Andrew L Miller,Sarah E Webb

Journal of experimental botany 63:1751-61 PubMed22213817

2012

A toolset of aequorin expression vectors for in planta studies of subcellular calcium concentrations in Arabidopsis thaliana.

Applications

WB

Species

Unspecified reactive species

Norbert Mehlmer,Nargis Parvin,Charlotte H Hurst,Marc R Knight,Markus Teige,Ute C Vothknecht

Analytical biochemistry 421:172-80 PubMed22067979

2011

A protein switch sensing system for the quantification of sulfate.

Applications

Unspecified application

Species

Unspecified reactive species

Krystal Teasley Hamorsky,Charles Mark Ensor,Patrizia Pasini,Sylvia Daunert

PloS one 2:e974 PubMed17912353

2007

Non-invasive in vivo imaging of calcium signaling in mice.

Applications

WB

Species

Unspecified reactive species

Kelly L Rogers,Sandrine Picaud,Emilie Roncali,Raphaël Boisgard,Cesare Colasante,Jacques Stinnakre,Bertrand Tavitian,Philippe Brûlet

Molecular microbiology 47:223-34 PubMed12492866

2002

Amiodarone induces a caffeine-inhibited, MID1-depedent rise in free cytoplasmic calcium in Saccharomyces cerevisiae.

Applications

Unspecified application

Species

Unspecified reactive species

William E Courchesne,Sedide Ozturk
View all publications
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Product promise

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