Anti-AFAP1L2 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

AFAP1L2 also known as actin filament-associated protein 1-like protein 2 is an important player in scaffolding and signaling mechanisms inside cells. The AFAP1L2 protein possesses a molecular mass of about 82 kDa and its expression finds its place in various tissues with a noted expression in adipose tissues and the liver. This protein interacts predominantly with actin filaments where it influences the organization of the cytoskeletal structure contributing significantly to maintaining cell shape and motility.

Biological function summary

AFAP1L2 plays a strong role in modulating cellular signaling pathways linked to cell motility and structural integrity. It interacts with various other proteins to ensure robust cytoskeletal organization and it functions critically in cellular signaling complexes. By forming associations with proteins such as FAK (focal adhesion kinase) AFAP1L2 supports the formation of multiprotein complexes which prove essential for cell movement and signal transduction processes.

Pathways

AFAP1L2 integrates into the integrin signaling and FAK pathways. Within these pathways it acts as an important intermediary modulating signals that affect cellular adhesion and movement. AFAP1L2 shows significant interaction with integrin-linked proteins directly contributing to downstream signaling that supports cell survival and proliferation. It controls key points in the pathway interplay that govern actin cytoskeleton dynamics and signaling cascades.

Associated diseases and disorders

Research connects AFAP1L2 to metastatic cancer progression and metabolic disorders like obesity. Dysregulation of AFAP1L2 expression disrupts normal cytoskeletal and signaling processes contributing to the increased mobility and invasiveness of cancerous cells. Additionally an imbalance involving AFAP1L2 in metabolic pathways affects lipid storage and insulin response linking it to obesity-related conditions. Through these diseases proteins such as PI3K and Akt interact with AFAP1L2 forming complex networks that exacerbate pathological states.