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AB106433

Anti-AFAP1L2 antibody

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(3 Publications)

Rabbit Polyclonal AFAP1L2 antibody. Suitable for WB and reacts with Mouse samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human AFAP1L2.

View Alternative Names

KIAA1914, XB130, AFAP1L2, Actin filament-associated protein 1-like 2, AFAP1-like protein 2

1 Images
Western blot - Anti-AFAP1L2 antibody (AB106433)
  • WB

Unknown

Western blot - Anti-AFAP1L2 antibody (AB106433)

Lane 1:

Western blot - Anti-AFAP1L2 antibody (ab106433) at 1 µg/mL

Lane 2:

Western blot - Anti-AFAP1L2 antibody (ab106433) at 2 µg/mL

All lanes:

Mouse liver tissue lysate at 15 µg

Predicted band size: 91 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Synthetic Peptide within Human AFAP1L2. The exact immunogen used to generate this antibody is proprietary information.

Q8N4X5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AFAP1L2 also known as actin filament-associated protein 1-like protein 2 is an important player in scaffolding and signaling mechanisms inside cells. The AFAP1L2 protein possesses a molecular mass of about 82 kDa and its expression finds its place in various tissues with a noted expression in adipose tissues and the liver. This protein interacts predominantly with actin filaments where it influences the organization of the cytoskeletal structure contributing significantly to maintaining cell shape and motility.
Biological function summary

AFAP1L2 plays a strong role in modulating cellular signaling pathways linked to cell motility and structural integrity. It interacts with various other proteins to ensure robust cytoskeletal organization and it functions critically in cellular signaling complexes. By forming associations with proteins such as FAK (focal adhesion kinase) AFAP1L2 supports the formation of multiprotein complexes which prove essential for cell movement and signal transduction processes.

Pathways

AFAP1L2 integrates into the integrin signaling and FAK pathways. Within these pathways it acts as an important intermediary modulating signals that affect cellular adhesion and movement. AFAP1L2 shows significant interaction with integrin-linked proteins directly contributing to downstream signaling that supports cell survival and proliferation. It controls key points in the pathway interplay that govern actin cytoskeleton dynamics and signaling cascades.

Research connects AFAP1L2 to metastatic cancer progression and metabolic disorders like obesity. Dysregulation of AFAP1L2 expression disrupts normal cytoskeletal and signaling processes contributing to the increased mobility and invasiveness of cancerous cells. Additionally an imbalance involving AFAP1L2 in metabolic pathways affects lipid storage and insulin response linking it to obesity-related conditions. Through these diseases proteins such as PI3K and Akt interact with AFAP1L2 forming complex networks that exacerbate pathological states.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation.
See full target information AFAP1L2
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Oncology letters 20:68 PubMed32863901

2020

Members of the miR-30 family inhibit the epithelial-to-mesenchymal transition of non-small-cell lung cancer cells by suppressing XB130 expression levels.

Applications

Unspecified application

Species

Unspecified reactive species

Kewei Song,Yinhui Jiang,Yan Zhao,Yuan Xie,Jianjiang Zhou,Wenfeng Yu,Qinrong Wang

Molecular carcinogenesis 59:557-568 PubMed32159887

2020

XB130, regulated by miR-203, miR-219, and miR-4782-3p, mediates the proliferation and metastasis of non-small-cell lung cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Qinrong Wang,Guohui Yang,Yinhui Jiang,Mei Luo,Chao Li,Yan Zhao,Yuan Xie,Kewei Song,Jianjiang Zhou

Molecular medicine reports 16:5592-5598 PubMed28849225

2017

XB130 enhances invasion and migration of human colorectal cancer cells by promoting epithelial‑mesenchymal transition.

Applications

Unspecified application

Species

Unspecified reactive species

Jiancheng Shen,Chang'e Jin,Yonglin Liu,Heping Rao,Jinrong Liu,Jie Li
View all publications
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