Anti-Aflatoxin B1 antibody [AFA-1]

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Aflatoxin B1 exerts its toxic effects by interacting with DNA and inducing mutations that can lead to cancer. It interacts with the cytochrome P450 enzyme complex in the liver where it undergoes bioactivation to form an epoxide. This reactive metabolite can covalently bind to DNA resulting in genotoxic stress. It does not form part of any large protein complexes on its own but relies on enzymatic conversion to exert its biological activity.

Pathways

AFB1 primarily involves the cytochrome P450 enzymatic system. This pathway activates AFB1 into a reactive epoxide linking it to the metabolic pathways of xenobiotic degradation. It is closely related to other cytochrome P450 enzymes such as CYP1A2 and CYP3A4 which also participate in metabolic activation and detoxification of various xenobiotics and drugs influencing their biological impact.