JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB203680

Anti-AGGF1 antibody

Be the first to review this product! Submit a review

|

(3 Publications)

Rabbit Polyclonal AGGF1 antibody. Suitable for WB and reacts with Mouse samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human AGGF1 aa 450-550 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

GPATC7, GPATCH7, VG5Q, AGGF1, Angiogenic factor with G patch and FHA domains 1, Angiogenic factor VG5Q, G patch domain-containing protein 7, Vasculogenesis gene on 5q protein, hVG5Q

1 Images
Western blot - Anti-AGGF1 antibody (AB203680)
  • WB

Supplier Data

Western blot - Anti-AGGF1 antibody (AB203680)

12% SDS PAGE

All lanes:

Western blot - Anti-AGGF1 antibody (ab203680) at 1/200 dilution

Lane 1:

Mouse liver tissue lysate

Lane 2:

Mouse intestine tissue lysate

Secondary

All lanes:

Goat Anti-Rabbit IgG Antibody (H+L), HRP Conjugated at 1/3000 dilution

Predicted band size: 81 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Synthetic Peptide within Human AGGF1 aa 450-550 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q8N302

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/1000", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AGGF1 also known as Angiogenic Factor with G-Patch and FHA Domains 1 is a protein involved in angiogenesis. This protein has a molecular mass of approximately 82 kDa. AGGF1 expresses in a variety of tissues with notable expression in endothelial cells. It functions by promoting blood vessel formation acting as an important player in vascular development and repair processes.
Biological function summary

AGGF1 participates in several cellular processes related to angiogenesis. It does not operate as part of a complex but it interacts with other signaling molecules to regulate endothelial cell proliferation and migration. Its role extends to cellular mechanisms such as apoptosis and cell survival adding to its importance in cardiovascular biology.

Pathways

AGGF1 is essential in the VEGF signaling pathway which is important for blood vessel formation and maintenance. It also influences the PI3K-AKT pathway a significant pathway for cell growth and survival. The interaction with VEGF and regulation of these pathways indicates its cooperation with proteins like VEGFR2 and AKT in mediating angiogenic responses.

AGGF1 plays a role in several cardiovascular diseases including coronary artery disease and small vessel disease. Its involvement in pathologies is linked to its interaction with proteins such as VEGF and to some extent TIE2 both of which are implicated in vascular malformations and cardiovascular dysfunction. Understanding AGGF1's function can aid in developing therapeutic strategies for these conditions.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.
See full target information AGGF1
style
left-column

Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Physiology international : PubMed35218336

2022

Neuroprotective effect of AGGF1 against isoflurane-induced cognitive dysfunction in aged rats through activating the PI3K/AKT signaling pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoping Wu,Xuan Zhang,Lei Zhao,Shan Jiang

BMC cancer 19:1252 PubMed31881864

2019

Elevated expression of AGGF1 predicts poor prognosis and promotes the metastasis of colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Zhang,Huimin Sun,Wanyuan Chen,Xianglei He

Oncotarget 8:111623-111630 PubMed29340079

2017

High expression of angiogenic factor AGGF1 is an independent prognostic factor for hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Jianfei Tu,Xihui Ying,Dengke Zhang,Qiaoyou Weng,Weibo Mao,Li Chen,Xulu Wu,Chaoyong Tu,Jiansong Ji,Yuan Huang
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB8227

Anti-beta Actin antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Western blot - Anti-beta Actin antibody - Loading Control (AB8227)

  • 5
  • 104
Primary Antibodies

AB13847

Anti-Caspase-3 antibody

KO Validated

Western blot - Anti-Caspase-3 antibody (AB13847)

  • 4
  • 56
Primary Antibodies

AB16502

Anti-NF-kB p65 antibody

BOND RX™ Validated|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NF-kB p65 antibody (AB16502)

  • 4
  • 40

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com