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AB62667

Anti-Agmatine antibody

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(2 Publications)

Chicken Polyclonal Agmatine antibody. Suitable for ICC and reacts with Chemical samples. Cited in 2 publications. Immunogen corresponding to Chemical / Small Molecule corresponding to Agmatine.

Key facts

Host species

Chicken

Clonality

Polyclonal

Isotype

IgY

Carrier free

No

Applications

ICC

applications

Specificity

Fixed tissue cross-reactivity tested with known targets at recommended dilution. No measurable glutaraldehyde-fixed tissue cross-reactivity (<1:1000) against L-alanine, gamma-aminobutyrate, L-citrulline, L-cysteine, D/L-glutamate, D/L-arginine, D/L-glutamine, glutathione, glycine, L-lysine, L-ornithine, L-serine, taurine, L-threonine, L-tryptophan, L-tyrosine.

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Complementary Products

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Primary Antibodies

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Primary Antibodies

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Primary Antibodies

AB74825

Anti-B4GALT3 antibody

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Chemical": { "ICC-species-checked": "guaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purity
IgY fraction
Purification notes
IgYs were separated from other yolk proteins by serial PEG6000 extractions using a modification of the method of Polsonet al Immunological Investigations. 1985, 14, 323-327.
Storage buffer
Preservative: 0.05% Thimerosal (merthiolate) Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Agmatine is a biological molecule derived from the amino acid arginine often referred to as decarboxylated arginine. It has a molecular mass of approximately 130.19 g/mol. Agmatine is found widely in various tissues with a high expression in the brain and other vital organs. Notably it is distributed in neurons where it modulates multiple physiological functions. Agmatine also appears endogenously in the human body and it can be detected in trace amounts.
Biological function summary

This compound plays important roles beyond being a metabolic product. It acts as a neuromodulator and neurotransmitter in the central nervous system. Agmatine interacts with multiple biochemical targets including ionotropic receptors and imidazoline receptors. It is also studied for being involved in signal transduction pathways. As part of its complex functions agmatine influences nitric oxide synthesis by modulating nitric oxide synthase activity.

Pathways

Several components and mechanisms connect agmatine to essential cellular processes. It plays roles in the polyamine pathway and influences the regulation of nitric oxide. These pathways contribute to cellular proliferation and angiogenesis. Agmatine interacts with related proteins like arginase and ornithine decarboxylase highlighting its regulative potential within the polyamine framework.

Different pathways show a strong connection between agmatine and certain health conditions. Studies indicate that agmatine may have implications in neurodegenerative diseases such as Alzheimer's disease due to its neuromodulatory activity. Additionally its impact on nitric oxide synthase links agmatine to cardiovascular diseases. These connections involve proteins such as amyloid precursor protein in Alzheimer's and enzymes in the nitric oxide pathway contributing to cardiovascular health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Agmatine
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Chembiochem : a European journal of chemical biology 14:2144-52 PubMed24106095

2013

Evaluation of UDP-GlcN derivatives for selective labeling of 5-(hydroxymethyl)cytosine.

Applications

Unspecified application

Species

Unspecified reactive species

Nan Dai,Jurate Bitinaite,Hang-Gyeong Chin,Sriharsa Pradhan,Ivan R Corrêa

The Journal of comparative neurology 521:2416-38 PubMed23348566

2013

Mapping kainate activation of inner neurons in the rat retina.

Applications

Unspecified application

Species

Unspecified reactive species

Lisa Nivison-Smith,Daniel Sun,Erica L Fletcher,Robert E Marc,Michael Kalloniatis
View all publications
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Product promise

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