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Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Rabbit Polyclonal AGPAT3 antibody. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human AGPAT3 aa 100-200.
IgG
Rabbit
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS, 0.87% Sodium chloride
Liquid
Polyclonal
IHC-P | WB | |
---|---|---|
Human | Tested | Tested |
Mouse | Predicted | Predicted |
Rat | Predicted | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 10 µg/mL | Notes Perform heat-mediated antigen retrieval before commencing with IHC staining protocol. |
Species | Dilution info | Notes |
---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/500.00000 - 1/1000.00000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:21173190). Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor (PubMed:21173190). Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA (PubMed:21173190). Has a preference for arachidonoyl-CoA as a donor (By similarity). Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lysophosphatidylinositol (LPI) into phosphatidylinositol (By similarity).
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma, 1-acylglycerol-3-phosphate O-acyltransferase 3, Lysophosphatidic acid acyltransferase gamma, 1-AGP acyltransferase 3, 1-AGPAT 3, LPAAT-gamma, UNQ759/PRO1490, LPAAT3, AGPAT3
Rabbit Polyclonal AGPAT3 antibody. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human AGPAT3 aa 100-200.
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma, 1-acylglycerol-3-phosphate O-acyltransferase 3, Lysophosphatidic acid acyltransferase gamma, 1-AGP acyltransferase 3, 1-AGPAT 3, LPAAT-gamma, UNQ759/PRO1490, LPAAT3, AGPAT3
IgG
Rabbit
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS, 0.87% Sodium chloride
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
AGPAT3 acts as an important mediator in lipid biosynthesis specifically in the triacylglycerol and glycerophospholipid pathways. It contributes to the synthesis of phospholipids which are critical for cell membrane integrity and function. AGPAT3 does not function within a complex but acts as an individual enzyme facilitating the elongation of acyl chains in phospholipids. The presence of AGPAT3 in the endoplasmic reticulum marks it as integral in cellular lipid assembly and regulation.
AGPAT3 also known as 1-acylglycerol-3-phosphate O-acyltransferase 3 is an enzyme that catalyzes the acylation of lysophosphatidic acid (LPA) to produce phosphatidic acid (PA). This enzyme performs its mechanical function in the endoplasmic reticulum and it plays a role in lipid metabolism. It has a mass of approximately 39 kDa. AGPAT3 expresses highly in tissues such as the heart skeletal muscle and adipose tissue suggesting its relevance in energy metabolism and fat storage.
AGPAT3 is involved in the glycerolipid biosynthesis pathway and phospholipid biosynthesis. Its activity affects the production of phosphatidic acid a precursor for the synthesis of various lipids such as diacylglycerol and triacylglycerol. AGPAT3 works in concert with other AGPAT family members contributing to an intricate network that regulates lipid metabolism.
AGPAT3 associates with metabolic conditions like obesity and related cardiovascular diseases. The disruption of AGPAT3's function can lead to lipid accumulation and altered lipid signaling. AGPAT3's role in lipid metabolism closely connects it to other proteins such as lipoprotein lipase (LPL) influencing lipid clearance and energy balance. Understanding AGPAT3's function and regulation could provide insights into therapeutic approaches for these metabolic diseases.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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Terms & Conditions.
All lanes: Western blot - Anti-AGPAT3 antibody (AB211435) at 1/500 dilution
All lanes: K562 cell lysate
Predicted band size: 43 kDa
Immunohistchemical analysis of formalin fixed, paraffin embedded Human kidney tissue labeling AGPAT3 with ab211435 at 10 μg/ml.
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