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AB231815

Anti-AGXT2 antibody

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(1 Publication)

Rabbit Polyclonal AGXT2 antibody. Suitable for WB, IHC-P and reacts with Pig, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human AGXT2 aa 250 to C-terminus.

View Alternative Names

AGT2, AGXT2, AGT 2, (R)-3-amino-2-methylpropionate--pyruvate transaminase, Beta-ALAAT II, Beta-alanine-pyruvate aminotransferase, D-3-aminoisobutyrate-pyruvate aminotransferase, D-AIBAT, D-beta-aminoisobutyrate-pyruvate aminotransferase

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AGXT2 antibody (AB231815)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AGXT2 antibody (AB231815)

Formalin-fixed, paraffin- embedded human liver tissue stained for AGXT2 using ab231815 at 1/10 dilution in immunohistochemical analysis. DAB staining.

Western blot - Anti-AGXT2 antibody (AB231815)
  • WB

Supplier Data

Western blot - Anti-AGXT2 antibody (AB231815)

All lanes:

Western blot - Anti-AGXT2 antibody (ab231815) at 1 µg/mL

All lanes:

Porcine liver tissue lysate

Predicted band size: 57 kDa

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Western blot - Anti-AGXT2 antibody (AB231815)
  • WB

Unknown

Western blot - Anti-AGXT2 antibody (AB231815)

All lanes:

Western blot - Anti-AGXT2 antibody (ab231815) at 1 µg/mL

All lanes:

Porcine kidney tissue lysate

Predicted band size: 57 kDa

true

Western blot - Anti-AGXT2 antibody (AB231815)
  • WB

Supplier Data

Western blot - Anti-AGXT2 antibody (AB231815)

All lanes:

Western blot - Anti-AGXT2 antibody (ab231815) at 1 µg/mL

All lanes:

Recombinant human AGXT2 protein.

Predicted band size: 28 kDa,34 kDa,57 kDa

Observed band size: 37 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, Pig

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human AGXT2 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9BYV1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/50 - 1/400", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/10 - 1/100", "IHCP-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/50 - 1/400", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AGXT2 also known as alanine--glyoxylate aminotransferase 2 is an enzyme with approximately 56 kDa mass. The enzyme is expressed mainly in the liver kidney and heart. AGXT2 catalyzes the transamination reaction between alanine and glyoxylate to produce pyruvate and glycine. It is critical for the cellular detoxification processes and the regulation of amino acid metabolism.
Biological function summary

This enzyme contributes to the conversion of glyoxylate therefore preventing its accumulation which can be harmful. AGXT2 is not part of a larger protein complex but it works closely with other enzyme systems involved in amino acid metabolism. Its activity maintains the balance between glycolate and glycine levels within the body which is essential for normal cellular function.

Pathways

AGXT2 functions in both the glyoxylate and dicarboxylate metabolism pathway as well as the broader amino acid metabolism pathways. Within these pathways its role connects it to other related proteins such as Glyoxylate reductase/hydroxypyruvate reductase (GRHPR) and Lactate dehydrogenase. These interactions contribute to maintaining homeostasis in intermediary metabolism.

AGXT2 abnormalities relate closely to primary hyperoxaluria type 2 and certain cardiovascular diseases. Mutations or deficiencies in AGXT2 can result in the overproduction of oxalate leading to kidney stone formation and renal damage. Additionally reduced AGXT2 activity might influence homocysteine levels potentially linking it to cardiovascular disorders. This relationship places AGXT2 in connection with other proteins such as cystathionine beta-synthase in the context of homocysteine metabolism.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Multifunctional aminotransferase with a broad substrate specifcity (PubMed : 20018850, PubMed : 23023372, PubMed : 24586340). Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor (By similarity). Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine (PubMed : 24586340). Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate (By similarity). Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA) (PubMed : 20018850, PubMed : 23023372). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (PubMed : 20018850, PubMed : 23023372).
See full target information AGXT2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Translational oncology 56:102381 PubMed40199156

2025

Tumor-derived immunoglobulin-like transcript 3 inhibition reshapes the immunosuppressive tumor microenvironment and potentiates programmed cell death ligand 1 blockade immunotherapy in lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Leirong Wang,Qing Li,Yanxin Sun,Shuyun Wang,Xuebing Fu,Xiufen Wang,Yan Zheng,Aiqin Gao,Yuping Sun,Juan Li
View all publications
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