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AB122009

Anti-AHDC1 antibody

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(1 Publication)

Rabbit Polyclonal AHDC1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human AHDC1 aa 1150-1300.

View Alternative Names

Transcription factor Gibbin, AT-hook DNA-binding motif-containing protein 1, AHDC1

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-AHDC1 antibody (AB122009)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-AHDC1 antibody (AB122009)

Immunofluorescent staining of Human cell line U-251 MG shows positivity in nucleus but not nucleoli. Recommended concentration of ab122009 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AHDC1 antibody (AB122009)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AHDC1 antibody (AB122009)

ab122009, at a 1/20 dilution, staining AHDC1 in paraffin-embedded Human pancreas tissue by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human AHDC1 aa 1150-1300. The exact immunogen used to generate this antibody is proprietary information.

Q5TGY3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AHDC1 also known as AT hook DNA binding motif containing 1 is a nuclear protein with a molecular mass of approximately 160 kDa. This protein is expressed in various tissues throughout the body including the heart kidney and brain. AHDC1 functions in the nucleus where it is believed to influence DNA processes due to its DNA binding capability. Researchers continue to study the specific mechanical actions of AHDC1 but its presence in critical body tissues demonstrates its significance in cellular function.
Biological function summary

AHDC1 influences developmental processes by affecting gene expression. It forms part of a protein complex that interacts with nuclear chromatin which suggests a role in transcription regulation. AHDC1's interaction within the nucleus possibly affects the transcription of genes critical for cell growth and division. The ability to influence nuclear architecture hints towards AHDC1's involvement in orchestrating complex genetic networks.

Pathways

AHDC1 integrates into genetic and signaling pathways important for cellular development. It participates in pathways involving the regulation of gene expression and chromatin remodeling. Known associations exist between AHDC1 and factors involved in chromatin modification like histone-related proteins highlighting its role in gene expression control. AHDC1’s involvement in transcription may link to other proteins in these pathways facilitating the activation or repression of genes necessary for proper cell cycle progression.

AHDC1 has been linked to neurodevelopmental disorders including Xia-Gibbs syndrome. Aberrations in AHDC1 expression or function have implications in cognitive disabilities and developmental delays. These disruptions also connect it to proteins involved in neural development highlighting the cascading effects of its dysfunction. Continued research may reveal additional connections between AHDC1 dysfunction and other conditions broadening its impact on understanding genetic disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed : 35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed : 35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed : 35585237).
See full target information AHDC1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Asian journal of andrology 27:245-253 PubMed39686771

2024

Novel homozygous SPAG17 variants cause human male infertility through multiple morphological abnormalities of spermatozoal flagella related to axonemal microtubule doublets.

Applications

Unspecified application

Species

Unspecified reactive species

Tao Liu,Fazal Rahim,Meng-Lei Yang,Meftah Uddin,Jing-Wei Ye,Imtiaz Ali,Yousaf Raza,Abu Mansoor,Muhammad Shoaib,Mujahid Hussain,Ihsan Khan,Basit Shah,Asad Khan,Ahmad Nisar,Hui Ma,Bo Xu,Wasim Shah,Qing-Hua Shi
View all publications
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Product promise

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