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AB76843

Anti-AHI1 antibody

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(1 Publication)

Rabbit Polyclonal AHI1 antibody. Suitable for WB, IHC-P, IHC-Fr and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Jouberin.

View Alternative Names

Jouberin, Abelson helper integration site 1 protein homolog, AHI-1, AHI1

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-Fr, WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human Jouberin. The exact immunogen used to generate this antibody is proprietary information.

Q8N157

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The AHI1 protein also known as Abelson helper integration site 1 protein weighs approximately 110 kDa. This protein plays an important role in cellular processes by interacting with the cytoskeleton and is expressed in various tissues with significant levels in the brain. AHI1 localizes to the centrosomes and is critical for intracellular signaling dynamics affecting cellular shape and polarity.
Biological function summary

The AHI1 protein impacts several cellular functions. It acts as a scaffold protein that is part of large protein complexes. In particular AHI1 interacts with other proteins like NPHP1 important for positioning ciliary transition zones. These interactions are vital for maintaining normal cilia function which influences signal transduction related to both neuronal and renal functions in the body.

Pathways

Functions of AHI1 include involvement in the Shh (Sonic hedgehog) signaling pathway and JAK-STAT signaling. These pathways are key for cell growth differentiation and proliferation. AHI1's role in the Shh pathway connects it with proteins such as Gli proteins while its association with the JAK-STAT pathway involves complex interactions with various janus kinases.

AHI1 mutations have strong associations with neurodevelopmental disorders such as Joubert syndrome and schizophrenia. In Joubert syndrome AHI1 interacts with CEP290 another protein involved in ciliary function leading to phenotypic manifestations when mutations disrupt this interaction. Similarly alterations in AHI1 can contribute to schizophrenia due to its role in neuronal signaling pathways and brain development.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development (PubMed : 21623382).
See full target information Jouberin
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell reports. Medicine 4:101277 PubMed37944531

2023

Personalized drug screening in patient-derived organoids of biliary tract cancer and its clinical application.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoxue Ren,Mingle Huang,Weixiang Weng,Yubin Xie,Yifan Wu,Shenghua Zhu,Ying Zhang,Dongming Li,Jiaming Lai,Shunli Shen,Jie Lin,Ming Kuang,Xiaoxing Li,Jun Yu,Lixia Xu
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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