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AB168104

Anti-AHNAK antibody

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(2 Publications)

Rabbit Polyclonal AHNAK antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human AHNAK.

View Alternative Names

PM227, AHNAK, Neuroblast differentiation-associated protein AHNAK, Desmoyokin

1 Images
Western blot - Anti-AHNAK antibody (AB168104)
  • WB

Unknown

Western blot - Anti-AHNAK antibody (AB168104)

All lanes:

Western blot - Anti-AHNAK antibody (ab168104) at 1 µg/mL

Lane 1:

AHNAK transfected 293T cell line lysate at 15 µL

Lane 2:

Non-transfected 293T cell line lysate at 15 µL

Predicted band size: 629 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human AHNAK.

Q09666

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AHNAK antibody (AB223762)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Horse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The AHNAK protein also known as "giant ankyrin repeat-containing protein" or "desmoyokin" has a large molecular mass of approximately 700 kDa. It is expressed in various tissues including heart skeletal muscle and brain. The protein is characterized by its repeated ankyrin-like motifs which are essential for protein-protein interactions. AHNAK is localized to the plasma membrane cytoplasm and sometimes the nucleus indicating its versatile roles within cells.
Biological function summary

AHNAK has key functions in cell structure and signaling. It can form a complex with other proteins such as S100 family proteins influencing calcium binding and signal transduction. This complex plays a role in the regulation of the cytoskeleton and membrane repair processes. Additionally AHNAK participates in cellular stress responses and impacts cell adhesion by interacting with membrane-associated proteins.

Pathways

AHNAK interacts with pathways involving calcium signaling and cytoskeletal organization. It links to the calcium-binding protein S100B facilitating downstream signaling that impacts cellular responses to external stimuli. Another pathway involves plasma membrane repair where AHNAK partners with annexin proteins to reseal damaged membranes and maintain cellular integrity.

AHNAK associates with cardiomyopathies and certain types of cancer. In cardiac conditions its interaction with proteins like dystrophin is important for maintaining muscle cell integrity during contraction. The dysregulation of AHNAK in cancer can influence cell motility and invasiveness highlighting its potential as a biomarker for tumor progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May be required for neuronal cell differentiation.
See full target information AHNAK
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Immunology 164:190-206 PubMed33987830

2021

Gm40600 promotes CD4 T-cell responses by interacting with Ahnak.

Applications

Unspecified application

Species

Unspecified reactive species

Youdi He,Ying Fang,Bing Zhai,Xiaoling Liu,Gaizhi Zhu,Shan Zhou,Yaqi Xu,Xiaoqian Wang,Wenting Su,Renxi Wang

International journal of oncology 53:266-274 PubMed29749468

2018

Inhibition of CD9 expression reduces the metastatic capacity of human hepatocellular carcinoma cell line MHCC97-H.

Applications

Unspecified application

Species

Unspecified reactive species

Qing Lin,Shifang Peng,Yixuan Yang
View all publications
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Product promise

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