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Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Rabbit Polyclonal AHNAK antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human AHNAK aa 4950-5150.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
IHC-P | ICC/IF | |
---|---|---|
Human | Tested | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/500.00000 - 1/1000.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 0.25000-2.00000 µg/mL | Notes Fixation/Permeabilization: PFA/Triton X-100. |
May be required for neuronal cell differentiation.
Neuroblast differentiation-associated protein AHNAK, Desmoyokin, PM227, AHNAK
Rabbit Polyclonal AHNAK antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human AHNAK aa 4950-5150.
Neuroblast differentiation-associated protein AHNAK, Desmoyokin, PM227, AHNAK
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
AHNAK has key functions in cell structure and signaling. It can form a complex with other proteins such as S100 family proteins influencing calcium binding and signal transduction. This complex plays a role in the regulation of the cytoskeleton and membrane repair processes. Additionally AHNAK participates in cellular stress responses and impacts cell adhesion by interacting with membrane-associated proteins.
The AHNAK protein also known as "giant ankyrin repeat-containing protein" or "desmoyokin" has a large molecular mass of approximately 700 kDa. It is expressed in various tissues including heart skeletal muscle and brain. The protein is characterized by its repeated ankyrin-like motifs which are essential for protein-protein interactions. AHNAK is localized to the plasma membrane cytoplasm and sometimes the nucleus indicating its versatile roles within cells.
AHNAK interacts with pathways involving calcium signaling and cytoskeletal organization. It links to the calcium-binding protein S100B facilitating downstream signaling that impacts cellular responses to external stimuli. Another pathway involves plasma membrane repair where AHNAK partners with annexin proteins to reseal damaged membranes and maintain cellular integrity.
AHNAK associates with cardiomyopathies and certain types of cancer. In cardiac conditions its interaction with proteins like dystrophin is important for maintaining muscle cell integrity during contraction. The dysregulation of AHNAK in cancer can influence cell motility and invasiveness highlighting its potential as a biomarker for tumor progression.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Paraffin embedded sections of human rectum tissue were stained for AHNAK with ab223709 at 1/500 dilution in immunohistochemical analysis.
PFA-fixed, Triton X-100 permeabilized A431 (human epidermoid carcinoma cell line) cells stained for AHNAK (green) using ab223709 at 4 μg/ml in ICC/IF.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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