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AB224055

Anti-AHNAK2 antibody

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Rabbit Polyclonal AHNAK2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human AHNAK2 aa 2600-2750.

View Alternative Names

C14orf78, KIAA2019, AHNAK2, Protein AHNAK2

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-AHNAK2 antibody (AB224055)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-AHNAK2 antibody (AB224055)

PFA-fixed, Triton X-100 permeabilized U-2 OS (human bone osteosarcoma epithelial cell line) cells stained for AHNAK2 (green) using ab224055 (4 μg/ml) in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AHNAK2 antibody (AB224055)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AHNAK2 antibody (AB224055)

Paraffin embedded human skin tissue stained for AHNAK2 with ab224055 at a 1/500 dilution in immunohistochemical analysis. No staining is observed.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AHNAK2 antibody (AB224055)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AHNAK2 antibody (AB224055)

Paraffin embedded human skin tissue stained for AHNAK2 with ab224055 at a 1/500 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human AHNAK2 aa 2600-2750. The exact immunogen used to generate this antibody is proprietary information.

Q8IVF2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AHNAK2 short for "AHNAK nucleoprotein 2" is a large ubiquitously expressed protein with a molecular mass of approximately 600 kDa. Scientists have identified it in various tissues with high levels in the heart lungs and skin. This protein belongs to the family of nucleoproteins which suggests its involvement in cellular structural functions. AHNAK2 is known to play a role in structural integrity as it interacts with components of the cytoskeleton and cell membrane.
Biological function summary

AHNAK2 influences the cellular processes of migration and proliferation. It interacts with members of the actin cytoskeleton and certain signaling pathways. AHNAK2 does not form part of a well-defined complex but shows associations with signaling molecules that manage cell shape and motility. Its interactions indicate a potential regulatory function in rearranging cytoskeletal structures which facilitates various dynamic cellular processes.

Pathways

AHNAK2 participates in the TGF-beta signaling pathway and the MAPK/ERK pathway. It strengthens these pathways especially by modulating cellular responses to external stimuli. The protein also associates with other signaling molecules like SMAD proteins in TGF-beta pathway contributing to the regulation of gene expression cell growth and development. AHNAK2’s involvement in this network indicates its role in turning extracellular information into intracellular actions.

Researchers have linked AHNAK2 to forms of cancer especially lung and pancreatic cancer. Elevated levels of AHNAK2 may relate to tumor progression and metastasis. Additional studies associate it with proteins like KRAS involved in signal transduction which suggests AHNAK2 might encourage oncogenic pathways that drive cancer development. Understanding AHNAK2 functions and interactions could lead to new insights into therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information AHNAK2
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Product promise

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