Mouse Polyclonal AHNAK2 antibody. Carrier free. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human AHNAK2 aa 5300 to C-terminus.
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- Oncology letters 14:3734-37402017iTRAQ-coupled 2D LC/MS-MS analysis of CXCR7-transfected papillary thyroid carcinoma cells: A new insight into CXCR7 regulation of papillary thyroid carcinoma progression and identification of potential biomarkers.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHengwei Zhang et. al.PubMed 28927140
Key facts
- Isotype
- IgG
- Host species
- Mouse
- Storage buffer
pH: 7.4
Constituents: 100% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human AHNAK2 aa 5300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q8IVF2
Reactivity data
Select an application| WB | |
|---|---|
| Recombinant fragment - Human | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Recombinant fragment - Human | Dilution info 1/500.00000 - 1/1000.00000 | Notes Antibody only tested against the recombinant fragment. We have no data on endogenous detection. |
Associated Products
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2 products for Alternative Product
Target data
Alternative names
C14orf78, KIAA2019, AHNAK2, Protein AHNAK2
Recommended products
Mouse Polyclonal AHNAK2 antibody. Carrier free. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human AHNAK2 aa 5300 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Mouse
- Storage buffer
pH: 7.4
Constituents: 100% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human AHNAK2 aa 5300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q8IVF2
- Carrier free
- Yes
- Purification technique
- Affinity purification Protein G
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
AHNAK2 short for "AHNAK nucleoprotein 2" is a large ubiquitously expressed protein with a molecular mass of approximately 600 kDa. Scientists have identified it in various tissues with high levels in the heart lungs and skin. This protein belongs to the family of nucleoproteins which suggests its involvement in cellular structural functions. AHNAK2 is known to play a role in structural integrity as it interacts with components of the cytoskeleton and cell membrane.
- Biological function summary
AHNAK2 influences the cellular processes of migration and proliferation. It interacts with members of the actin cytoskeleton and certain signaling pathways. AHNAK2 does not form part of a well-defined complex but shows associations with signaling molecules that manage cell shape and motility. Its interactions indicate a potential regulatory function in rearranging cytoskeletal structures which facilitates various dynamic cellular processes.
- Pathways
AHNAK2 participates in the TGF-beta signaling pathway and the MAPK/ERK pathway. It strengthens these pathways especially by modulating cellular responses to external stimuli. The protein also associates with other signaling molecules like SMAD proteins in TGF-beta pathway contributing to the regulation of gene expression cell growth and development. AHNAK2’s involvement in this network indicates its role in turning extracellular information into intracellular actions.
- Associated diseases and disorders
Researchers have linked AHNAK2 to forms of cancer especially lung and pancreatic cancer. Elevated levels of AHNAK2 may relate to tumor progression and metastasis. Additional studies associate it with proteins like KRAS involved in signal transduction which suggests AHNAK2 might encourage oncogenic pathways that drive cancer development. Understanding AHNAK2 functions and interactions could lead to new insights into therapeutic strategies.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-AHNAK2 antibody (ab70053)
C-terminal AHNAK2 recombinant fragment expression in transfected 293T cell line. The immunogen (fragment) is from 5313 to 5795aa of the whole AHNAK2 sequence (5795aa) C-terminal AHNAK2 fragment (immunogen) expression in transfected 293T cells. Predicted size of the fragement is 53kDa. The fragment is from aa 5313 to 5795 of human AHNAK2.
All lanes: Western blot - Anti-AHNAK2 antibody (ab70053)
Predicted band size: 617 kDa
Observed band size: 65 kDa
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