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AB70053

Anti-AHNAK2 antibody

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(2 Publications)

Mouse Polyclonal AHNAK2 antibody. Carrier free. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human AHNAK2 aa 5300 to C-terminus.

View Alternative Names

C14orf78, KIAA2019, AHNAK2, Protein AHNAK2

1 Images
Western blot - Anti-AHNAK2 antibody (AB70053)
  • WB

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Western blot - Anti-AHNAK2 antibody (AB70053)

C-terminal AHNAK2 recombinant fragment expression in transfected 293T cell line. The immunogen (fragment) is from 5313 to 5795aa of the whole AHNAK2 sequence (5795aa) C-terminal AHNAK2 fragment (immunogen) expression in transfected 293T cells. Predicted size of the fragement is 53kDa. The fragment is from aa 5313 to 5795 of human AHNAK2.

All lanes:

Western blot - Anti-AHNAK2 antibody (ab70053)

Predicted band size: 617 kDa

Observed band size: 65 kDa

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Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human AHNAK2 aa 5300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8IVF2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant fragment - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p>Antibody only tested against the recombinant fragment. We have no data on endogenous detection.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AHNAK2 short for "AHNAK nucleoprotein 2" is a large ubiquitously expressed protein with a molecular mass of approximately 600 kDa. Scientists have identified it in various tissues with high levels in the heart lungs and skin. This protein belongs to the family of nucleoproteins which suggests its involvement in cellular structural functions. AHNAK2 is known to play a role in structural integrity as it interacts with components of the cytoskeleton and cell membrane.
Biological function summary

AHNAK2 influences the cellular processes of migration and proliferation. It interacts with members of the actin cytoskeleton and certain signaling pathways. AHNAK2 does not form part of a well-defined complex but shows associations with signaling molecules that manage cell shape and motility. Its interactions indicate a potential regulatory function in rearranging cytoskeletal structures which facilitates various dynamic cellular processes.

Pathways

AHNAK2 participates in the TGF-beta signaling pathway and the MAPK/ERK pathway. It strengthens these pathways especially by modulating cellular responses to external stimuli. The protein also associates with other signaling molecules like SMAD proteins in TGF-beta pathway contributing to the regulation of gene expression cell growth and development. AHNAK2’s involvement in this network indicates its role in turning extracellular information into intracellular actions.

Researchers have linked AHNAK2 to forms of cancer especially lung and pancreatic cancer. Elevated levels of AHNAK2 may relate to tumor progression and metastasis. Additional studies associate it with proteins like KRAS involved in signal transduction which suggests AHNAK2 might encourage oncogenic pathways that drive cancer development. Understanding AHNAK2 functions and interactions could lead to new insights into therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information AHNAK2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Technology in cancer research & treatment 19:1533033820957006 PubMed33000678

2020

Down-Regulation of AHNAK2 Inhibits Cell Proliferation, Migration and Invasion Through Inactivating the MAPK Pathway in Lung Adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Dong-Wei Wang,Hai-Zheng Zheng,Na Cha,Xiao-Jie Zhang,Min Zheng,Ming-Ming Chen,Li-Xiang Tian

Oncology letters 14:3734-3740 PubMed28927140

2017

iTRAQ-coupled 2D LC/MS-MS analysis of CXCR7-transfected papillary thyroid carcinoma cells: A new insight into CXCR7 regulation of papillary thyroid carcinoma progression and identification of potential biomarkers.

Applications

Unspecified application

Species

Unspecified reactive species

Hengwei Zhang,Lei Yang,Zhangyi Liu,Chenxi Liu,Xuyong Teng,Lei Zhang,Bo Yin,Zhen Liu
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