Anti-AHRR antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The aryl hydrocarbon receptor repressor (AHRR) is a protein that functions by inhibiting the activity of the aryl hydrocarbon receptor (AHR). It achieves this by competing with AHR for binding to AHR nuclear translocator (ARNT) forming a complex that prevents AHR from activating its target genes. AHRR weighs approximately 78 kDa and is expressed in various tissues particularly in those with a high exposure to environmental toxins such as the liver and lungs. This expression pattern suggests its role in modulating responses to external chemicals.

Biological function summary

AHRR is essential in regulating gene expression involved in responses to xenobiotics. It is part of the AHR signaling complex functioning as a feedback inhibitor that controls the extent and duration of AHR-mediated transcriptional activity. By doing so AHRR helps maintain cellular homeostasis and protects against potential harmful effects of excessive activation of AHR pathways. It also influences the differentiation and function of immune cells and has roles in development and metabolism.

Pathways

AHRR is integral in the xenobiotic metabolism and dioxin signaling pathways. These pathways involve the detoxification processes of harmful compounds. AHRR interacts with proteins like AHR and ARNT to modulate these pathways ensuring that cells respond correctly to environmental pollutants. Through these interactions AHRR also influences the balance of cellular proliferation and apoptosis acting to maintain physiological functions and prevent toxicity.

Associated diseases and disorders

AHRR has associations with cancer and autoimmune diseases. Dysregulation of AHRR expression can lead to increased susceptibility to cancers as AHR activity becomes unchecked promoting tumor growth and progression. Additionally aberrant AHRR function is linked with autoimmune disorders due to its role in controlling immune system activities. AHRR interacts closely with AHR and ARNT in these disease contexts highlighting the importance of its regulatory functions in maintaining health.