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AB234817

Anti-AHRR antibody

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(2 Publications)

Rabbit Polyclonal AHRR antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human AHRR aa 250-550.

View Alternative Names

BHLHE77, KIAA1234, AHRR, Aryl hydrocarbon receptor repressor, AhR repressor, AhRR, Class E basic helix-loop-helix protein 77, bHLHe77

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-AHRR antibody (AB234817)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-AHRR antibody (AB234817)

HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for AHRR (green) using ab234817 at 1/100 dilution in ICC/IF, followed by Alexa Fluor® 488 conjugated Goat Anti-Rabbit IgG (H+L).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human AHRR aa 250-550. The exact immunogen used to generate this antibody is proprietary information.

A9YTQ3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The aryl hydrocarbon receptor repressor (AHRR) is a protein that functions by inhibiting the activity of the aryl hydrocarbon receptor (AHR). It achieves this by competing with AHR for binding to AHR nuclear translocator (ARNT) forming a complex that prevents AHR from activating its target genes. AHRR weighs approximately 78 kDa and is expressed in various tissues particularly in those with a high exposure to environmental toxins such as the liver and lungs. This expression pattern suggests its role in modulating responses to external chemicals.
Biological function summary

AHRR is essential in regulating gene expression involved in responses to xenobiotics. It is part of the AHR signaling complex functioning as a feedback inhibitor that controls the extent and duration of AHR-mediated transcriptional activity. By doing so AHRR helps maintain cellular homeostasis and protects against potential harmful effects of excessive activation of AHR pathways. It also influences the differentiation and function of immune cells and has roles in development and metabolism.

Pathways

AHRR is integral in the xenobiotic metabolism and dioxin signaling pathways. These pathways involve the detoxification processes of harmful compounds. AHRR interacts with proteins like AHR and ARNT to modulate these pathways ensuring that cells respond correctly to environmental pollutants. Through these interactions AHRR also influences the balance of cellular proliferation and apoptosis acting to maintain physiological functions and prevent toxicity.

AHRR has associations with cancer and autoimmune diseases. Dysregulation of AHRR expression can lead to increased susceptibility to cancers as AHR activity becomes unchecked promoting tumor growth and progression. Additionally aberrant AHRR function is linked with autoimmune disorders due to its role in controlling immune system activities. AHRR interacts closely with AHR and ARNT in these disease contexts highlighting the importance of its regulatory functions in maintaining health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.
See full target information AHRR
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:23847 PubMed40615482

2025

Ring-finger protein RNF126 promotes prostate cancer progression via regulation of MBNL1.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Jiang,Ji Li,Jiali Zhang,Yulei Zhao,Guoqin He,Xiaohui Yao

Cancers 16: PubMed39199657

2024

Development of Ex Vivo Analysis for Examining Cell Composition, Immunological Landscape, Tumor and Immune Related Markers in Non-Small-Cell Lung Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Elena G Ufimtseva,Margarita S Gileva,Ruslan V Kostenko,Vadim V Kozlov,Lyudmila F Gulyaeva
View all publications
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