AB112528

Anti-AHSG antibody

Name: Anti-AHSG antibody (ab112528) | Abcam
Brand: Abcam Limited
SKU: AB112528
Price: 535 USD
Availability: InStock

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(5 Publications)

Rabbit Polyclonal FETUA antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human AHSG.

View Alternative Names

FETUA, PRO2743, AHSG, Alpha-2-HS-glycoprotein, Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein, Fetuin-A

1 Images

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Western blot - Anti-AHSG antibody (AB112528)

All lanes:

Western blot - Anti-AHSG antibody (ab112528)

Lane 1:

Recombinant Human Alpha 2 HS Glycoprotein protein at 0.01 µg

Lane 2:

Recombinant Human Alpha 2 HS Glycoprotein protein at 0.005 µg

Lane 3:

Recombinant Human Alpha 2 HS Glycoprotein protein at 0.0025 µg

Predicted band size: 39 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Synthetic Peptide within Human AHSG. The exact immunogen used to generate this antibody is proprietary information.

P02765

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p>The detection limit for Alpha 2 HS Glycoprotein is approximately 2.5ng/lane.under non-reducing and reducing conditions.</p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate) Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The target AHSG also known as fetuin-A or alpha-2-HS-glycoprotein is a multifunctional glycoprotein with an approximate mass of 64-68 kDa. It is mainly expressed in the liver and secreted into the bloodstream. AHSG exhibits a wide range of interactions with different cell types and biological molecules playing key roles in mineralization inhibition of arterial calcification and modulation of immune responses.

Biological function summary

AHSG protein serves multiple functions including acting as an inhibitor of insulin receptor autophosphorylation and serine-threonine kinase activities. AHSG is part of a complex dynamic process involving calcium metabolism and bone mineralization. It binds to transforming growth factor-beta (TGF-β) and other proteins modulating cellular signals and maintaining homeostasis in tissues. The regulation of calcium ion balance by AHSG can protect against ectopic calcification preventing potential damage.

Pathways

Calcium signaling and the insulin signaling pathways integrate AHSG functions. AHSG interacts with proteins like insulin receptor and those in the canonical Wnt signaling pathway influencing glucose metabolism and bone development. The balance of its interactions in these pathways helps maintain metabolic homeostasis and skeletal integrity reflecting its versatile roles within complex networks.

AHSG has connections to metabolic syndrome and calcific aortic valve disease. Abnormal levels of AHSG can disrupt metabolic functions and contribute to type 2 diabetes development by affecting insulin receptor activity. It also associates with calcification-related proteins in vascular tissues linking it to cardiovascular diseases. Understanding these connections is important for potential therapeutic targeting of AHSG in related pathologies.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.

See full target information AHSG

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Journal of neuroinflammation 19:269 PubMed36333786

2022

Fetuin-A alleviates neuroinflammation against traumatic brain injury-induced microglial necroptosis by regulating Nrf-2/HO-1 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Pengzhan Zhao,Yutian Wei,Guangchi Sun,Lei Xu,Tian Wang,Yufei Tian,Honglu Chao,Yiming Tu,Jing Ji

Journal of cellular physiology 235:7604-7619 PubMed32437028

2020

Proteomic analysis of underlying apoptosis mechanisms of human retinal pigment epithelial ARPE-19 cells in response to mechanical stretch.

Applications

Unspecified application

Species

Unspecified reactive species

Fancheng Yan,Meng Gao,Yiyi Gong,Lin Zhang,Nanping Ai,Jingxue Zhang,Yijie Chai,Shen Wu,Qian Liu,Xian Jiang,Haiteng Deng,Wu Liu

Biomolecules 10: PubMed32260542

2020

Tick and Host Derived Compounds Detected in the Cement Complex Substance.

Applications

Unspecified application

Species

Unspecified reactive species

Margarita Villar,Iván Pacheco,Octavio Merino,Marinela Contreras,Lourdes Mateos-Hernández,Eduardo Prado,Dina Karen Barros-Picanço,José Francisco Lima-Barbero,Sara Artigas-Jerónimo,Pilar Alberdi,Isabel G Fernández de Mera,Agustín Estrada-Peña,Alejandro Cabezas-Cruz,José de la Fuente

PloS one 12:e0186227 PubMed29016670

2017

A novel function of N-linked glycoproteins, alpha-2-HS-glycoprotein and hemopexin: Implications for small molecule compound-mediated neuroprotection.

Applications

Unspecified application

Species

Unspecified reactive species

Takuya Kanno,Kaori Yasutake,Kazunori Tanaka,Shinji Hadano,Joh-E Ikeda

BioMed research international 2015:209745 PubMed26448929

2015

Plasma Protein Biomarker Candidates for Myelodysplastic Syndrome Subgroups.

Applications

Unspecified application

Species

Unspecified reactive species

Pavel Majek,Klara Pecankova,Jaroslav Cermak,Jan E Dyr

View all publications

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Product promise

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For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-AHSG antibody

Western blot - Anti-AHSG antibody (AB112528)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (5)

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